KEGG   ENZYME: 1.1.1.248Help
Entry
EC 1.1.1.248                Enzyme                                 

Name
salutaridine reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
salutaridinol:NADP+ 7-oxidoreductase
Reaction(IUBMB)
salutaridinol + NADP+ = salutaridine + NADPH + H+ [RN:R04697]
Reaction(KEGG)
Substrate
salutaridinol [CPD:C05220];
NADP+ [CPD:C00006]
Product
salutaridine [CPD:C05179];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.
History
EC 1.1.1.248 created 1999, modified 2001
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13392  salutaridine reductase (NADPH)
Reference
1
  Authors
Gerady, R. and Zenk, M.H.
  Title
Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum.
  Journal
Phytochemistry 34:125-132 (1993)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.248
IUBMB Enzyme Nomenclature: 1.1.1.248
ExPASy - ENZYME nomenclature database: 1.1.1.248
BRENDA, the Enzyme Database: 1.1.1.248
CAS: 152743-95-8

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