KEGG   ENZYME: 1.1.1.255Help
Entry
EC 1.1.1.255                Enzyme                                 

Name
mannitol dehydrogenase;
MTD;
NAD+-dependent mannitol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
mannitol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-mannitol + NAD+ = D-mannose + NADH + H+ [RN:R07135]
Reaction(KEGG)
Substrate
D-mannitol [CPD:C00392];
NAD+ [CPD:C00003]
Product
D-mannose [CPD:C00159];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.
History
EC 1.1.1.255 created 2000
Orthology
K00095  mannitol dehydrogenase
Reference
1  [PMID:1416989]
  Authors
Stoop JM, Pharr DM.
  Title
Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots.
  Journal
Arch Biochem Biophys 298:612-9 (1992)
DOI:10.1016/0003-9861(92)90456-7
Reference
2  [PMID:7630943]
  Authors
Stoop JM, Williamson JD, Conkling MA, Pharr DM.
  Title
Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures.
  Journal
Plant Physiol 108:1219-25 (1995)
Reference
3  [PMID:7638158]
  Authors
Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM.
  Title
Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3.
  Journal
Proc Natl Acad Sci U S A 92:7148-52 (1995)
DOI:10.1073/pnas.92.16.7148
  Sequence
Reference
4
  Authors
Stoop, J.M.H., Chilton, W.S. and Pharr, D.M.
  Title
Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery.
  Journal
Phytochemistry 43:1145-1150 (1996)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.255
IUBMB Enzyme Nomenclature: 1.1.1.255
ExPASy - ENZYME nomenclature database: 1.1.1.255
BRENDA, the Enzyme Database: 1.1.1.255
CAS: 144941-29-7

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