KEGG   ENZYME: 1.1.1.263Help
Entry
EC 1.1.1.263                Enzyme                                 

Name
1,5-anhydro-D-fructose reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
1,5-anhydro-D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
1,5-anhydro-D-glucitol + NADP+ = 1,5-anhydro-D-fructose + NADPH + H+ [RN:R05682]
Reaction(KEGG)
Substrate
1,5-anhydro-D-glucitol [CPD:C07326];
NADP+ [CPD:C00006]
Product
1,5-anhydro-D-fructose [CPD:C06485];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces pyridine-3-aldehyde and 2,3-butanedione. Acetaldehyde, 2-dehydroglucose (glucosone) and glucuronate are poor substrates, but there is no detectable action on glucose, mannose and fructose.
History
EC 1.1.1.263 created 2000
Orthology
K13981  1,5-anhydro-D-fructose reductase
Genes
HSA: 83592(AKR1E2)
PTR: 746502(AKR1E2)
PPS: 100985849(AKR1E2)
GGO: 101143645(AKR1E2)
PON: 100462621(AKR1E2)
NLE: 100603254(AKR1E2)
MCC: 711035(AKR1E2)
MCF: 101925198(AKR1E2)
CSAB: 103237804(AKR1E2)
RRO: 104678923(AKR1E2)
RBB: 108513974(AKR1E2)
CJC: 100404287(AKR1E2)
SBQ: 101050607(AKR1E2)
MMU: 56043(Akr1e1)
RNO: 307091(Akr1e2)
CGE: 100750439(Akr1e2)
NGI: 103725894(Akr1e2)
CCAN: 109678870(Akr1e2)
OCU: 100345389(AKR1E2)
TUP: 102478936(AKR1E2)
CFA: 608809(AKR1E2)
AML: 100464743(AKR1E2)
UMR: 103676233(AKR1E2)
FCA: 101097814(AKR1E2)
PTG: 102968954(AKR1E2)
AJU: 106988131(AKR1E2)
BTA: 615959
BOM: 102270889(AKR1E2)
BIU: 109567630(AKR1E2)
PHD: 102328049(AKR1E2)
CHX: 102189770(AKR1E2)
OAS: 101110956(AKR1E2)
SSC: 733633(AKR1E2)
ECB: 100070632(AKR1E2)
EPZ: 103555590(AKR1E2)
EAI: 106827463(AKR1E2)
MYB: 102256598(AKR1E2)
MYD: 102752243(AKR1E2)
PALE: 102889300(AKR1E2)
LAV: 100661345
TMU: 101356649
MDO: 100018228(AKR1E2)
SHR: 100927444
 » show all
Taxonomy
Reference
1  [PMID:9504428]
  Authors
Sakuma M, Kametani S, Akanuma H.
  Title
Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose.
  Journal
J Biochem 123:189-93 (1998)
  Sequence
[ssc:733633]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.263
IUBMB Enzyme Nomenclature: 1.1.1.263
ExPASy - ENZYME nomenclature database: 1.1.1.263
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.263
BRENDA, the Enzyme Database: 1.1.1.263
CAS: 206138-19-4

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