KEGG   ENZYME: 1.1.1.270Help
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R05691]
Reaction(KEGG)
R05691;
(other) R04328 R07495
Show
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7) 100989828(DHRS11)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399(HSD17B7)
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
AJU: 106980443(DHRS11) 106986761(HSD17B7)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
PHD: 102316552(HSD17B7) 102329492(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
RSS: 109447836(DHRS11) 109455663(HSD17B7)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
OAA: 100077820(DHRS11)
GGA: 395172(DHRS11) 424367(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
SCAN: 103820184(DHRS11) 103824326(HSD17B7)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
NNI: 104010459(HSD17B7) 104016400(DHRS11)
ACUN: 113483111(HSD17B7) 113487258(DHRS11)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
PMUR: 107294873(DHRS11) 107302880(HSD17B7)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108714499(hsd17b7.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 768185(hsd17b7) 791578(dhrs11a)
IPU: 108260417(dhrs11) 108271889(hsd17b7)
PHYP: 113531061(dhrs11) 113538418(hsd17b7)
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11)
BTER: 100648073
HST: 105183111
OBO: 105274796
PCF: 106791135
TNL: 113498949
MNG: MNEG_6911
SCE: YLR100W(ERG27)
ERC: Ecym_4279
KMX: KLMA_40163(ERG27)
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
CAUR: QG37_04950
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
 » show all
Taxonomy
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5

DBGET integrated database retrieval system