KEGG   ENZYME: 1.1.1.270Help
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R05691]
Reaction(KEGG)
R05691;
(other) R04328 R07495
Show
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7) 100989828(DHRS11)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399(HSD17B7)
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
AJU: 106965562 106980443(DHRS11) 106986761(HSD17B7)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
PHD: 102316552(HSD17B7) 102329492(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
RSS: 109447836(DHRS11) 109455663(HSD17B7)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
OAA: 100077820(DHRS11)
GGA: 395172(DHRS11) 424367(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108714499(hsd17b7.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 768185(hsd17b7) 791578(dhrs11a)
IPU: 108260417(dhrs11) 108271889(hsd17b7)
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11)
ACEP: 105619439
HST: 105183111
PCF: 106791135
MNG: MNEG_6911
SCE: YLR100W(ERG27)
ERC: Ecym_4279
KMX: KLMA_40163(ERG27)
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
CAUR: QG37_04950
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
 » show all
Taxonomy
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5

KEGG   ENZYME: 1.1.1.62Help
Entry
EC 1.1.1.62                 Enzyme                                 

Name
17beta-estradiol 17-dehydrogenase;
20alpha-hydroxysteroid dehydrogenase;
17beta,20alpha-hydroxysteroid dehydrogenase;
17beta-estradiol dehydrogenase;
estradiol dehydrogenase;
estrogen 17-oxidoreductase;
17beta-HSD;
HSD17B7
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17beta-estradiol:NAD(P)+ 17-oxidoreductase
Reaction(IUBMB)
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ [RN:R02352 R02353]
Reaction(KEGG)
Substrate
17beta-estradiol;
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
estrone [CPD:C00468];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3beta-hydroxysteroid 3-dehydrogenase [3]. The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20alpha-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.
History
EC 1.1.1.62 created 1965, modified 1983, modified 1986, modified 2012
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00044  17beta-estradiol 17-dehydrogenase
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
K13368  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13370  17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 3292(HSD17B1) 3294(HSD17B2) 51144(HSD17B12) 51478(HSD17B7) 79154(DHRS11) 7923(HSD17B8) 8630(HSD17B6)
PTR: 100614183 454269(HSD17B2) 454598(DHRS11) 454689(HSD17B1) 466046 741010(HSD17B12) 746685(HSD17B8) 747814(HSD17B7)
PPS: 100971612(HSD17B12) 100983435(HSD17B2) 100984876 100985156(HSD17B7) 100989828(DHRS11) 100993294(HSD17B8) 100994126(HSD17B1) 100996145(HSD17B6)
GGO: 101126579(HSD17B12) 101131453(HSD17B2) 101133645(DHRS11) 101137638(HSD17B7) 101139911(HSD17B1) 101143846(HSD17B8) 101153072(HSD17B6)
PON: 100439025(HSD17B12) 100446761(HSD17B7) 100450428(DHRS11) 100456547(HSD17B2) 100456666 100458219(HSD17B6) 100458375 100461538(HSD17B8)
NLE: 100580130(DHRS11) 100587120(HSD17B7) 100588757(HSD17B2) 100600308(HSD17B12) 100600794(HSD17B1) 100606923(HSD17B6) 100607728(HSD17B8)
MCC: 106993263(HSD17B12) 710392(HSD17B1) 713549(HSD17B6) 713823(DHRS11) 714282(HSD17B2) 718119(HSD17B8) 720399(HSD17B7)
MCF: 101867269(HSD17B12) 101926544(HSD17B6) 102119721(HSD17B2) 102122077(HSD17B1) 102127673(HSD17B7) 102133734(DHRS11) 102134563(HSD17B8)
CSAB: 103221677(HSD17B8) 103223654(HSD17B7) 103233373(HSD17B2) 103237147(HSD17B12) 103238543(HSD17B6) 103242795(DHRS11) 103243404(HSD17B1)
RRO: 104656967(HSD17B7) 104657981(HSD17B8) 104671622(HSD17B2) 104672997(DHRS11) 104673659(HSD17B6) 104673891(HSD17B12) 104680245(HSD17B1)
RBB: 108516069(HSD17B6) 108518333(HSD17B1) 108519261(HSD17B12) 108521311(HSD17B2) 108526295(DHRS11) 108535633 108540288(HSD17B8)
CJC: 100387390(HSD17B6) 100390710(HSD17B2) 100399351(HSD17B12) 100409004(HSD17B1) 100410416(HSD17B7) 100415468(DHRS11) 100415565(HSD17B8)
SBQ: 101030366(HSD17B2) 101037623(HSD17B12) 101042328(HSD17B8) 101042351(HSD17B1) 101047238(HSD17B7) 101049784(DHRS11) 101054253(HSD17B6)
MMU: 14979(H2-Ke6) 15485(Hsd17b1) 15486(Hsd17b2) 15490(Hsd17b7) 192970(Dhrs11) 27400(Hsd17b6) 56348(Hsd17b12)
RNO: 100362350 25322(Hsd17b1) 286964(Hsd17b6) 29540(Hsd17b7) 360583(Dhrs11) 361802(Hsd17b8) 79243(Hsd17b2) 84013(Hsd17b12)
CGE: 100750866(Hsd17b1) 100751291(Hsd17b12) 100751897(Hsd17b2) 100762147(Hsd17b6) 100763193(Dhrs11) 100766230(Hsd17b8) 100767580(Hsd17b7)
NGI: 103730224(Hsd17b6) 103732605(Dhrs11) 103735900(Hsd17b1) 103739734(Hsd17b8) 103746669(Hsd17b12) 103746788(Hsd17b7) 103748738(Hsd17b2)
HGL: 101699287(Hsd17b6) 101704213(Dhrs11) 101706276 101712707(Hsd17b7) 101717552(Hsd17b12) 101719685(Hsd17b2) 101720493(Hsd17b1) 101726130(Hsd17b8)
CCAN: 109680173 109680174 109686095 109686670(Hsd17b8) 109687306(Hsd17b1) 109690973(Hsd17b7) 109691233(Dhrs11) 109700741(Hsd17b12)
OCU: 100008778(HSD17B7) 100009478(HSD17B1) 100346603(HSD17B12) 100349261 100350282(DHRS11) 100353430(HSD17B8) 100358604(HSD17B2) 103347152
TUP: 102473205(HSD17B7) 102481007(DHRS11) 102481564(HSD17B2) 102482283(HSD17B1) 102485005(HSD17B6) 102494154(HSD17B8) 102495234(HSD17B12)
CFA: 475939(HSD17B12) 481118(HSD17B6) 489690(HSD17B2) 491129(DHRS11) 607570(HSD17B1) 607895(HSD17B8) 609364(HSD17B7)
AML: 100474694(HSD17B6) 100475452(HSD17B8) 100477716(HSD17B7) 100479742(HSD17B1) 100483445(DHRS11) 100484147(HSD17B12) 100484508(HSD17B2)
UMR: 103656323(HSD17B6) 103658287(HSD17B7) 103662132(HSD17B2) 103665501(HSD17B8) 103667445(DHRS11) 103672348(HSD17B12) 103672576(HSD17B1)
ORO: 101367938(HSD17B12) 101368538(HSD17B7) 101368715(HSD17B6) 101372465(DHRS11) 101374521(HSD17B8) 101375503(HSD17B1) 101379076(HSD17B2)
FCA: 101082595(HSD17B12) 101083482(HSD17B7) 101083724(DHRS11) 101085592(HSD17B2) 101086309 101088341(HSD17B6) 101091417(HSD17B1) 111556166
PTG: 102953856(DHRS11) 102958819(HSD17B2) 102958840(HSD17B1) 102963001(HSD17B12) 102968316(HSD17B7) 102968797(HSD17B8) 102971783(HSD17B6)
AJU: 106965562 106972611(HSD17B1) 106976117(HSD17B8) 106978054(HSD17B12) 106980443(DHRS11) 106984011(HSD17B2) 106986761(HSD17B7) 106986922(HSD17B6)
BTA: 353107(HSD17B1) 505212(HSD17B7) 508455 510264(DHRS11) 515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6) 789567(HSD17B12)
BOM: 102266348(HSD17B7) 102267490(DHRS11) 102274407(HSD17B12) 102278627 102278674(HSD17B2) 102281071(HSD17B1) 102283510(HSD17B6) 102286352(HSD17B8)
BIU: 109553253 109559345 109569664(HSD17B12) 109572870 109572993(HSD17B2) 109574096(DHRS11) 109574544(HSD17B1) 109576549(HSD17B8) 109577890(HSD17B7)
PHD: 102315709 102316552(HSD17B7) 102323155 102327736(HSD17B1) 102329492(DHRS11) 102332625(HSD17B6) 102336871(HSD17B2) 102340413(HSD17B8) 102344762
CHX: 102169696 102176160(DHRS11) 102179058(HSD17B7) 102182621(HSD17B2) 102182909(HSD17B1) 102185066(HSD17B6) 102186887(HSD17B12) 102189913(HSD17B8)
OAS: 100913161(HSD17B2) 101105400(HSD17B6) 101109465(DHRS11) 101110013(HSD17B7) 101110086(HSD17B12) 101110778(HSD17B1) 101112590 101116612(HSD17B8)
SSC: 100147712(HSD17B1) 100154372(HSD17B8) 100155418(HSD17B7) 100312972(HSD17B12) 100312973(HSD17B2) 100513307(DHRS11) 100620470
CFR: 102504651(HSD17B8) 102505228 102507556(DHRS11) 102508382 102512546(HSD17B7) 102514993(HSD17B2) 102515430(HSD17B12) 102523786(HSD17B1)
CDK: 105089442(HSD17B2) 105090463(HSD17B1) 105092702(HSD17B7) 105095461 105096750 105097850(DHRS11) 105098297 105098315 105101392(HSD17B8) 105106832(HSD17B12)
BACU: 102998439(HSD17B12) 103006419(HSD17B8) 103008169(HSD17B6) 103011691(DHRS11) 103014202(HSD17B2) 103014331(HSD17B7) 103017434 103019221
LVE: 103068441(HSD17B12) 103069867(DHRS11) 103070082(HSD17B1) 103070446(HSD17B2) 103076064(HSD17B6) 103084050(HSD17B7) 103088201(HSD17B8)
OOR: 101273198 101278328(DHRS11) 101278484(HSD17B6) 101279942(HSD17B12) 101283453(HSD17B1) 101284697(HSD17B2) 101286750(HSD17B7) 101287044(HSD17B8)
ECB: 100036556(HSD17B1) 100050075(HSD17B12) 100052840 100052892 100059061(HSD17B7) 100061414(HSD17B8) 100070719 100071416(DHRS11) 100146214(HSD17B2)
EPZ: 103541177(HSD17B8) 103545357 103550362(HSD17B1) 103554456(DHRS11) 103556323 103556451(HSD17B12) 103558215(HSD17B2) 103559639(HSD17B7) 103565330(HSD17B6) 103566841
EAI: 106823694(HSD17B7) 106826452(HSD17B1) 106832532(HSD17B2) 106832977(HSD17B6) 106834606(HSD17B8) 106843965(HSD17B12) 106844689(DHRS11) 106848436
MYB: 102251181(HSD17B7) 102252900(HSD17B8) 102256830(HSD17B1) 102260774(HSD17B2) 102262752(DHRS11) 102263289 102263627(HSD17B12)
MYD: 102751454(HSD17B2) 102758451 102763053(HSD17B1) 102765268(DHRS11) 102766664(HSD17B8) 102766960(HSD17B12) 102767046(HSD17B7)
HAI: 109378375(HSD17B2) 109379798(DHRS11) 109391968(HSD17B12) 109392309(HSD17B7) 109392392(HSD17B8) 109395793(HSD17B1)
RSS: 109441958 109447836(DHRS11) 109450930(HSD17B8) 109452917 109453728(HSD17B2) 109455108(HSD17B12) 109455663(HSD17B7) 109455881(HSD17B1) 109459904
PALE: 102882881(HSD17B2) 102883634(HSD17B6) 102889386(HSD17B12) 102889883(HSD17B8) 102892079(HSD17B7) 102894290(DHRS11) 102898145(HSD17B1)
LAV: 100656306(HSD17B12) 100657790 100673012(HSD17B1) 100673988(HSD17B2) 100676060 100676239(DHRS11) 100676343(HSD17B7) 104847005(HSD17B8) 111749606
MDO: 100011776(HSD17B1) 100013277(HSD17B12) 100016071(HSD17B7) 100025234(HSD17B8) 100031815(HSD17B2) 100618596(DHRS11)
SHR: 100914913(HSD17B8) 100917982(HSD17B12) 100919259(HSD17B1) 100921563(HSD17B2) 100923950 100926227(HSD17B7) 100931687 100933320(DHRS11)
OAA: 100076931(HSD17B2) 100077820(DHRS11) 100079057(HSD17B12)
GGA: 395172(DHRS11) 395641(HSD17B1) 415807(HSD17B2) 424367(HSD17B7) 769787(HSD17B12)
MGP: 100542399(DHRS11) 100542640(HSD17B7) 100549838(HSD17B2) 104911119(HSD17B12)
CJO: 107314810(HSD17B12) 107317140(HSD17B7) 107319415(HSD17B2) 107322636(DHRS11) 107325152 107325318
APLA: 101792379(HSD17B2) 101796287(DHRS11) 101799136(HSD17B7) 101803586(HSD17B12)
ACYG: 106041628(HSD17B7) 106044159(HSD17B12) 106044875(HSD17B2) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100223843(HSD17B12) 100228039(HSD17B2) 100230987(DHRS11) 100231423 101233632(HSD17B1)
GFR: 102031952(DHRS11) 102039377(HSD17B2) 102039695(HSD17B12) 102042580(HSD17B7) 102043161(HSD17B1)
FAB: 101806967(DHRS11) 101807632(HSD17B12) 101810836(HSD17B1) 101810951(HSD17B2) 101818521(HSD17B7)
PHI: 102100450(HSD17B1) 102103079(HSD17B2) 102106801(HSD17B12) 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107206004(HSD17B12) 107209789(HSD17B2) 107213026(DHRS11) 107215156(HSD17B1)
CCAE: 111930136(HSD17B12) 111932684(HSD17B7) 111934744(HSD17B2) 111937859(DHRS11) 111939996(HSD17B1)
CCW: 104688088(HSD17B12) 104690988(DHRS11) 104691825(HSD17B2) 104695594(HSD17B7)
FPG: 101912846(DHRS11) 101915382(HSD17B2) 101917180(HSD17B12) 101919410(HSD17B7)
FCH: 102048922(HSD17B2) 102049990(HSD17B1) 102050282(DHRS11) 102056639(HSD17B12) 102059217(HSD17B7)
CLV: 102085015(HSD17B12) 102090168(DHRS11) 102095570(HSD17B2) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7) 104133743(HSD17B2) 104134096(HSD17B12)
AAM: 106483270(HSD17B2) 106491088(HSD17B1) 106494687(DHRS11) 106498375(HSD17B12) 106499711(HSD17B7)
ASN: 102368497 102370921 102371169 102373198(HSD17B1) 102374189(HSD17B7) 102375872(HSD17B2) 102381002(HSD17B12) 112551119(DHRS11)
AMJ: 102559362(HSD17B12) 102561890(DHRS11) 102564718(HSD17B1) 102565865(HSD17B7) 102567845 102571332 102574309(HSD17B2) 106737258(HSD17B8)
PSS: 102444001 102445815(HSD17B12) 102452802(DHRS11) 102453351 102453984(HSD17B2) 102454079 102455451 102458050(HSD17B1) 102461698(HSD17B7) 112544543
CMY: 102929636(HSD17B8) 102938030(HSD17B12) 102939820 102941631(HSD17B2) 102942502(HSD17B1) 102944543(HSD17B6) 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936075(HSD17B1) 101936463(DHRS11) 101936532(HSD17B8) 101941193(HSD17B2) 101950937(HSD17B12) 101953232(HSD17B7)
PVT: 110071325 110075560(DHRS11) 110081502(HSD17B12) 110081655(HSD17B7) 110090097(HSD17B2) 110091148(HSD17B8) 110091362
PBI: 103049647(HSD17B12) 103058540(HSD17B2) 103063132(HSD17B7) 103063622 103065679(DHRS11)
GJA: 107108933(DHRS11) 107109831(HSD17B2) 107112070(HSD17B8) 107119118(HSD17B12) 107120158 107120904(HSD17B6) 107121042(HSD17B7)
XLA: 108700217(hsd17b8.S) 108710804 108711776 108714085(hsd17b2.L) 108714499(hsd17b7.L) 379747(hsd17b12.S) 398882(rdh16.L) 444506(LOC100497556.S) 495218(hsd17b12.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 100135184(rdh16) 100489679(hsd17b1) 100497002(hsd17b2) 100497556 496708(dhrs11) 548963(hsd17b7) 549425(hsd17b8) 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108786564(HSD17B2) 108788379(HSD17B8) 108794729 108799042(HSD17B1) 108800692 108801354(HSD17B7)
DRE: 322626(hsd17b12b) 327417(hsd17b12a) 402842(hsd17b1) 449537(hsd17b2) 64815(hsd17b8) 768185(hsd17b7) 791578(dhrs11a)
IPU: 100528251(dh12b) 108259770 108260417(dhrs11) 108271889(hsd17b7) 108275383(hsd17b12) 108275401(Hsd17b2) 108275553(hsd17b1)
LCO: 104922399(hsd17b12) 104923446(dhrs11) 104925842 104925916(hsd17b1) 104925933 104930791(hsd17b7) 104933390(hsd17b8) 104933511 104937328 104938964(hsd17b2) 109142059
CSEM: 103376747 103378812 103379612(hsd17b2) 103379805(hsd17b12) 103393165(hsd17b1) 103393879(hsd17b8) 103394917(dhrs11) 103395421 103395808
BPEC: 110158370 110159491(hsd17b1) 110160324 110162559 110162637(hsd17b2) 110163629 110165106(dhrs11) 110173336(hsd17b8) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109952509(hsd17b8) 109959449 109960466(dhrs11) 109964241(hsd17b1) 109965090 109966957 109969153(hsd17b2) 109973524(hsd17b12)
ELS: 105005658(hsd17b8) 105006117(hsd17b12) 105013369(hsd17b1) 105018101(hsd17b2) 105023923 105024805 105025310 105025666(dhrs11) 105030986
SFM: 108918746 108921710(dhrs11) 108934676 108935177(hsd17b7) 108935620(hsd17b8) 108938265 108941709(hsd17b1) 108942280(hsd17b12)
LCM: 102348492(HSD17B7) 102348665 102360275(HSD17B2) 102361445(HSD17B8) 102362094(HSD17B12) 102362545(DHRS11) 102364827(HSD17B1)
CMK: 103174968(hsd17b12) 103180036(hsd17b7) 103180635(dhrs11) 103191276
CIN: 100180521 100184861 100186135 445663(17-beta-HSD)
DME: Dmel_CG1444(spidey) Dmel_CG3603(CG3603)
DER: 6551636
DPE: 6600780
DSI: Dsimw501_GD16628(Dsim_GD16628) Dsimw501_GD16868(Dsim_GD16868)
DWI: 6649310
NVI: 100121752
MDL: 103569315
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F09E10.3(dhs-25) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4) CELE_Y39A1A.11(dhs-11)
CBR: CBG11441 CBG18334(Cbr-dhs-11) CBG19695(Cbr-let-767) CBG24510(Cbr-dhs-25)
BMY: Bm1_45995
TSP: Tsp_02573
ATH: AT1G24470(KCR2) AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
CANN: 107860712
NTO: 104087941
DOSA: Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299200-00(Os06g0299200) Os06t0299300-01(Os06g0299300) Os06t0300000-01(Os06g0300000)
ATS: 109733083(LOC109733083) 109733956(LOC109733956) 109733958(LOC109733958) 109736758(LOC109736758) 109743960(LOC109743960) 109744922(LOC109744922) 109745871(LOC109745871) 109746082(LOC109746082) 109746886(LOC109746886) 109747761(LOC109747761) 109755743(LOC109755743) 109756557(LOC109756557) 109765204(LOC109765204) 109765210(LOC109765210) 109766544(LOC109766544) 109766795(LOC109766795) 109768745(LOC109768745) 109771085(LOC109771085) 109772730(LOC109772730) 109773274(LOC109773274) 109773689(LOC109773689) 109779269(LOC109779269) 109781113(LOC109781113) 109781925(LOC109781925) 109782273(LOC109782273)
PPP: 112290473
MNG: MNEG_6911
APRO: F751_1671
SCE: YBR159W(IFA38)
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
CAUR: QG37_06149
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MGR: MGG_05096
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
DFA: DFA_11026
EHI: EHI_165070(127.t00009)
PYO: PY17X_0523800(PY05567)
PCB: PCHAS_052260(PC000268.05.0)
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
Taxonomy
Reference
1  [PMID:4314937]
  Authors
Kautsky MP, Hagerman DD.
  Title
17 Beta-estradiol dehydrogenase of ovine ovaries.
  Journal
J Biol Chem 245:1978-84 (1970)
Reference
2  [PMID:14413943]
  Authors
LANGER LJ, ALEXANDER JA, ENGEL LL.
  Title
Human placental estradiol-17 beta dehydrogenase. II. Kinetics and substrate specificities.
  Journal
J Biol Chem 234:2609-14 (1959)
Reference
3  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.62
IUBMB Enzyme Nomenclature: 1.1.1.62
ExPASy - ENZYME nomenclature database: 1.1.1.62
BRENDA, the Enzyme Database: 1.1.1.62
CAS: 9028-61-9

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