KEGG   ENZYME: 1.1.1.276Help
Entry
EC 1.1.1.276                Enzyme                                 

Name
serine 3-dehydrogenase (NADP+);
serine 3-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-serine:NADP+ 3-oxidoreductase
Reaction(IUBMB)
L-serine + NADP+ = 2-aminoacetaldehyde + CO2 + NADPH + H+ (overall reaction) [RN:R10984];
(1a) L-serine + NADP+ = 2-aminomalonate semialdehyde + NADPH + H+ [RN:R06126];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:R06830]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065];
NADP+ [CPD:C00006];
2-aminomalonate semialdehyde [CPD:C11822]
Product
2-aminoacetaldehyde [CPD:C06735];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080];
2-aminomalonate semialdehyde [CPD:C11822]
Comment
NAD+ cannot replace NADP+ [cf. EC 1.1.1.387, serine 3-dehydrogenase (NAD+)].
History
EC 1.1.1.276 created 2003, modified 2015
Orthology
K05886  serine 3-dehydrogenase (NADP+)
Genes
XFA: XF_0145
XFT: PD_0114(ydfG)
XFM: Xfasm12_0122
XFN: XfasM23_0107
XFF: XFLM_05845
XCC: XCC3864
XCB: XC_3948
XCA: xcc-b100_4048
XCP: XCR_0425
XCV: XCV4032
XAX: XACM_3813
XAC: XAC3919
XOO: XOO0491
XOM: XOO0458(XOO0458)
XOP: PXO_02915
XOR: XOC_4237
XAL: XALC_0369
SML: Smlt0396
SMT: Smal_0278
SMZ: SMD_0316
PSD: DSC_00090
HAR: HEAR2402
ATU: Atu4110(sdh)
RIR: BN877_II1239(ydfG)
ZMO: ZMO0226
ZMN: Za10_0988
ZMM: Zmob_0788
ZMB: ZZ6_0988
ZMI: ZCP4_1022
SPHM: G432_06740
ALI: AZOLI_p20658(ydfG)
AVA: Ava_2888
CCH: Cag_0924
 » show all
Taxonomy
Reference
1  [PMID:12092831]
  Authors
Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H.
  Title
Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens.
  Journal
Biosci Biotechnol Biochem 66:1137-9 (2002)
  Sequence
[atu:Atu4110]
Reference
2  [PMID:9028042]
  Authors
Chowdhury EK, Higuchi K, Nagata S, Misono H.
  Title
A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens.
  Journal
Biosci Biotechnol Biochem 61:152-7 (1997)
  Sequence
[atu:Atu4110]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.276
IUBMB Enzyme Nomenclature: 1.1.1.276
ExPASy - ENZYME nomenclature database: 1.1.1.276
BRENDA, the Enzyme Database: 1.1.1.276
CAS: 9038-55-5

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