KEGG   ENZYME: 1.1.1.282Help
Entry
EC 1.1.1.282                Enzyme                                 

Name
quinate/shikimate dehydrogenase;
YdiB
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-quinate:NAD(P)+ 3-oxidoreductase
Reaction(IUBMB)
(1) L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H + H+ [RN:R01872 R06846];
(2) shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H + H+ [RN:R02413 R06847]
Reaction(KEGG)
Substrate
L-quinate [CPD:C00296];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
shikimate [CPD:C00493]
Product
3-dehydroquinate [CPD:C00944];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
3-dehydroshikimate [CPD:C02637]
Comment
This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, shikimate dehydrogenase, in that it can use both quinate and shikimate as substrate and either NAD+ or NADP+ as acceptor.
History
EC 1.1.1.282 created 2004
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K05887  quinate/shikimate dehydrogenase
Genes
ECO: b1692(ydiB)
ECJ: JW1682(ydiB)
ECD: ECDH10B_1828(ydiB)
EBW: BWG_1506(ydiB)
ECOK: ECMDS42_1365(ydiB)
ECE: Z2720(ydiB)
ECS: ECs2399(aroE)
ECF: ECH74115_2408
ETW: ECSP_2259(ydiB)
ELX: CDCO157_2233(aroE)
EOJ: ECO26_2420(ydiB)
EOI: ECO111_2161(ydiB)
EOH: ECO103_1835(ydiB)
ECOO: ECRM13514_2187(aroE)
ECOH: ECRM13516_2092(aroE)
ECG: E2348C_1777(ydiB)
EOK: G2583_2089(ydiB)
ESO: O3O_13860
ESM: O3M_11740
ESL: O3K_11775
ELH: ETEC_1725
ECC: c2087(ydiB)
ECP: ECP_1639
ECI: UTI89_C1884(ydiB)
ECV: APECO1_768(ydiB)
ECY: ECSE_1815
ECR: ECIAI1_1745(ydiB)
ECQ: ECED1_1891(ydiB)
ECK: EC55989_1859(ydiB)
ECT: ECIAI39_1366(ydiB)
EOC: CE10_1966(ydiB)
EUM: ECUMN_1981(ydiB)
ECZ: ECS88_1742(ydiB)
ESE: ECSF_1552
EBR: ECB_01661(ydiB)
EBD: ECBD_1954
EKF: KO11_14285(ydiB)
EAB: ECABU_c19460(ydiB)
EDJ: ECDH1ME8569_1636(ydiB)
ENA: ECNA114_1739(ydiB)
ELW: ECW_m1861(ydiB)
ELL: WFL_09110(ydiB)
ELC: i14_1909(aroE)
ELD: i02_1909(aroE)
ELP: P12B_c1391(aroE)
EBL: ECD_01661(ydiB)
EBE: B21_01650(ydiB)
ELF: LF82_2870(ydiB)
ECOI: ECOPMV1_01791(ydiB)
ECOJ: P423_09035
ECOS: EC958_1912(ydiB)
STM: STM1359(ydiB)
SEO: STM14_1650(aroE_1)
SEY: SL1344_1293(aroE)
SEJ: STMUK_1326(aroE)
SEB: STM474_1364(aroE)
SEF: UMN798_1416(aroE)
SENR: STMDT2_12921(aroE)
SEND: DT104_13371(aroE)
SENI: CY43_06920
SEI: SPC_2371(aroE)
SEC: SCH_1378(ydiB)
SHB: SU5_01977
SENS: Q786_08455
SED: SeD_A1984
SEG: SG1757(ydiB)
SEL: SPUL_1177(ydiB)
SEGA: SPUCDC_1177(ydiB)
SET: SEN1685(ydiB)
SENA: AU38_08725
SENO: AU37_08730
SENV: AU39_08735
SENQ: AU40_09735
SENL: IY59_08920
SEEP: I137_05420
SENE: IA1_06705
SFL: SF1722(aroE)
SFX: S1854(ydiB)
SFV: SFV_1718(ydiB)
SFE: SFxv_1929(ydiB)
SFN: SFy_2467
SFS: SFyv_2522
SFT: NCTC1_01868(ydiB)
SSN: SSON_1462(ydiB)
SDY: SDY_1475(ydiB)
ENF: AKI40_1900(ydiB)
CAMA: F384_06180
 » show all
Taxonomy
Reference
1  [PMID:12637497]
  Authors
Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ.
  Title
Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities.
  Journal
J Biol Chem 278:19463-72 (2003)
DOI:10.1074/jbc.M300794200
  Sequence
[eco:b1692]
Reference
2  [PMID:12624088]
  Authors
Benach J, Lee I, Edstrom W, Kuzin AP, Chiang Y, Acton TB, Montelione GT, Hunt JF.
  Title
The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase.
  Journal
J Biol Chem 278:19176-82 (2003)
DOI:10.1074/jbc.M301348200
  Sequence
[eco:b1692]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.282
IUBMB Enzyme Nomenclature: 1.1.1.282
ExPASy - ENZYME nomenclature database: 1.1.1.282
BRENDA, the Enzyme Database: 1.1.1.282

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