KEGG   ENZYME: 1.1.1.286Help
Entry
EC 1.1.1.286                Enzyme                                 

Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004];
2-oxoadipate [CPD:C00322];
H+ [CPD:C00080]
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K17753  isocitrate--homoisocitrate dehydrogenase
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Taxonomy
Reference
1  [PMID:15845397]
  Authors
Miyazaki K.
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.286
IUBMB Enzyme Nomenclature: 1.1.1.286
ExPASy - ENZYME nomenclature database: 1.1.1.286
BRENDA, the Enzyme Database: 1.1.1.286

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