KEGG   ENZYME: 1.1.1.287Help
Entry
EC 1.1.1.287                Enzyme                                 

Name
D-arabinitol dehydrogenase (NADP+);
NADP+-dependent D-arabitol dehydrogenase;
ARD1p;
D-arabitol dehydrogenase 1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-arabinitol:NADP+ oxidoreductase
Reaction(IUBMB)
(1) D-arabinitol + NADP+ = D-xylulose + NADPH + H+ [RN:R07143];
(2) D-arabinitol + NADP+ = D-ribulose + NADPH + H+ [RN:R07144]
Reaction(KEGG)
Substrate
D-arabinitol [CPD:C01904];
NADP+ [CPD:C00006]
Product
D-xylulose [CPD:C00310];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-ribulose [CPD:C00309]
Comment
The enzyme from the rust fungus Uromyces fabae can use D-arabinitol and D-mannitol as substrates in the forward direction and D-xylulose, D-ribulose and, to a lesser extent, D-fructose as substrates in the reverse direction. This enzyme carries out the reactions of both EC 1.1.1.11, D-arabinitol 4-dehydrogenase and EC 1.1.1.250, D-arabinitol 2-dehydrogenase, but unlike them, uses NADP+ rather than NAD+ as cofactor. D-Arabinitol is capable of quenching reactive oxygen species involved in defense reactions of the host plant.
History
EC 1.1.1.287 created 2005
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K17818  D-arabinitol dehydrogenase (NADP+)
Genes
MGR: MGG_01114
TMN: UCRPA7_4120
SSCK: SPSK_09459
NHE: NECHADRAFT_78747
MAW: MAC_06529
MAJ: MAA_07660
PLJ: VFPFJ_06970
VAL: VDBG_05181
VDA: VDAG_08929
CFJ: CFIO01_05463
MBE: MBM_09044
ANI: AN0443.2
ANG: ANI_1_452014(An01g03480)
ABE: ARB_06173
TVE: TRV_00619
PTE: PTT_18102
CNE: CNC06260
CNB: CNBC0940
ABP: AGABI1DRAFT116829(AGABI1DRAFT_116829) AGABI1DRAFT46050(AGABI1DRAFT_46050)
ABV: AGABI2DRAFT145143(AGABI2DRAFT_145143) AGABI2DRAFT194619(AGABI2DRAFT_194619)
 » show all
Taxonomy
Reference
1  [PMID:15796718]
  Authors
Link T, Lohaus G, Heiser I, Mendgen K, Hahn M, Voegele RT.
  Title
Characterization of a novel NADP(+)-dependent D-arabitol dehydrogenase from the plant pathogen Uromyces fabae.
  Journal
Biochem J 389:289-95 (2005)
DOI:10.1042/BJ20050301
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.287
IUBMB Enzyme Nomenclature: 1.1.1.287
ExPASy - ENZYME nomenclature database: 1.1.1.287
BRENDA, the Enzyme Database: 1.1.1.287

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