KEGG   ENZYME: 1.1.1.289Help
Entry
EC 1.1.1.289                Enzyme                                 

Name
sorbose reductase;
Sou1p
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glucitol:NADP+ oxidoreductase
Reaction(IUBMB)
D-glucitol + NADP+ = L-sorbose + NADPH + H+ [RN:R07346]
Reaction(KEGG)
Substrate
D-glucitol [CPD:C00794];
NADP+ [CPD:C00006]
Product
L-sorbose [CPD:C00247];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction occurs predominantly in the reverse direction. This enzyme can also convert D-fructose into D-mannitol, but more slowly. Belongs in the short-chain dehydrogenase family.
History
EC 1.1.1.289 created 2006
Pathway
ec00051  Fructose and mannose metabolism
Orthology
K17742  sorbose reductase
K19633  sorbose reductase
Genes
KLA: KLLA0_E24003g
KMX: KLMA_10715(SOU2) KLMA_10783(SOU1)
LTH: KLTH0E13134g KLTH0F18062g KLTH0H14564g
ZRO: ZYRO0A11902g ZYRO0G22440g
TDL: TDEL_0B02360(TDEL0B02360) TDEL_0H00150(TDEL0H00150) TDEL_0H04540(TDEL0H04540)
PPA: PAS_chr4_0754
DHA: DEHA2E08910g
PIC: PICST_38255(SOU1)
PGU: PGUG_05385 PGUG_05388 PGUG_05464 PGUG_05466
SPAA: SPAPADRAFT_148284 SPAPADRAFT_58963 SPAPADRAFT_60851 SPAPADRAFT_61649 SPAPADRAFT_62532
CDU: CD36_32760 CD36_45870(SOU2) CD36_45880(SOU1)
SLB: AWJ20_3417(SPS19)
NTE: NEUTE1DRAFT115988(NEUTE1DRAFT_115988) NEUTE1DRAFT117650(NEUTE1DRAFT_117650)
MGR: MGG_07455
ANG: ANI_1_2328074(An08g09340) ANI_1_438064(An07g03570)
ABE: ARB_02722
TVE: TRV_00610
PNO: SNOG_01607 SNOG_15488(AY788902)
CNB: CNBI0900
GOX: GOX1432
GOH: B932_1684
GDI: GDI0886(mtlK)
GDJ: Gdia_1133
GXY: GLX_20590
GXL: H845_2922
 » show all
Taxonomy
Reference
1  [PMID:16134116]
  Authors
Greenberg JR, Price NP, Oliver RP, Sherman F, Rustchenko E.
  Title
Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:957-69 (2005)
DOI:10.1002/yea.1282
  Sequence
Reference
2
  Authors
Greenberg, J.R., Price, N.P., Oliver, R.P., Sherman, F. and Rustchenko, E.
  Title
Erratum report: Candida albicans SOU1 encodes a sorbose reductase required for L-sorbose utilization.
  Journal
Yeast 22:1171 (2005)
Reference
3
  Authors
Sugisawa, T., Hoshino, T. and Fujiwara, A.
  Title
Purification and properties of NADPH-linked L-sorbose reductase from Gluconobacter melanogenus N44-1.
  Journal
Agric Biol Chem 55:2043-2049 (1991)
Reference
4  [PMID:11790761]
  Authors
Shinjoh M, Tazoe M, Hoshino T.
  Title
NADPH-dependent L-sorbose reductase is responsible for L-sorbose assimilation in Gluconobacter suboxydans IFO 3291.
  Journal
J Bacteriol 184:861-3 (2002)
DOI:10.1128/JB.184.3.861-863.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.289
IUBMB Enzyme Nomenclature: 1.1.1.289
ExPASy - ENZYME nomenclature database: 1.1.1.289
BRENDA, the Enzyme Database: 1.1.1.289
CAS: 138440-90-1

DBGET integrated database retrieval system