KEGG   ENZYME: 1.1.1.295Help
Entry
EC 1.1.1.295                Enzyme                                 

Name
momilactone-A synthase;
momilactone A synthase;
OsMAS
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide:NAD(P)+ oxidoreductase
Reaction(IUBMB)
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P)+ = momilactone A + NAD(P)H + H+ [RN:R08916 R08917]
Reaction(KEGG)
Substrate
3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide [CPD:C18016];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
momilactone A [CPD:C18015];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The rice phytoalexin momilactone A is a diterpenoid secondary metabolite that is involved in the defense mechanism of the plant. Momilactone A is produced in response to attack by a pathogen through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. The enzyme, which catalyses the last step in the biosynthesis of momilactone A, can use both NAD+ and NADP+ but activity is higher with NAD+ [1].
History
EC 1.1.1.295 created 2008
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13070  momilactone-A synthase
Genes
OSA: 4335093
Taxonomy
Reference
1  [PMID:12005050]
  Authors
Atawong A, Hasegawa M, Kodama O.
  Title
Biosynthesis of rice phytoalexin: enzymatic conversion of 3beta-hydroxy-9beta-pimara-7,15-dien-19,6beta-olide to momilactone A.
  Journal
Biosci Biotechnol Biochem 66:566-70 (2002)
DOI:10.1271/bbb.66.566
  Sequence
[osa:4335093]
Reference
2  [PMID:17872948]
  Authors
Shimura K, Okada A, Okada K, Jikumaru Y, Ko KW, Toyomasu T, Sassa T, Hasegawa M, Kodama O, Shibuya N, Koga J, Nojiri H, Yamane H.
  Title
Identification of a biosynthetic gene cluster in rice for momilactones.
  Journal
J Biol Chem 282:34013-8 (2007)
DOI:10.1074/jbc.M703344200
  Sequence
[osa:4335093]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.295
IUBMB Enzyme Nomenclature: 1.1.1.295
ExPASy - ENZYME nomenclature database: 1.1.1.295
BRENDA, the Enzyme Database: 1.1.1.295

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