KEGG   ENZYME: 1.1.1.298Help
Entry
EC 1.1.1.298                Enzyme                                 

Name
3-hydroxypropionate dehydrogenase (NADP+);
3-hydroxypropanoate dehydrogenase (NADP+);
3-hydroxypropionate:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-hydroxypropanoate:NADP+ oxidoreductase
Reaction(IUBMB)
3-hydroxypropanoate + NADP+ = malonate semialdehyde + NADPH + H+ [RN:R09289]
Reaction(KEGG)
Substrate
3-hydroxypropanoate [CPD:C01013];
NADP+ [CPD:C00006]
Product
malonate semialdehyde [CPD:C00222];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75 [3]. Different from EC 1.1.1.59 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.
History
EC 1.1.1.298 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01120  Microbial metabolism in diverse environments
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
K15039  3-hydroxypropionate dehydrogenase (NADP+)
Genes
RRS: RoseRS_3201
RCA: Rcas_2929
CAU: Caur_2614
CHL: Chy400_2826
CAG: Cagg_1256
CTM: Cabther_B0159
STO: STK_15070
SSO: SSO0647(hdb-1)
SOL: Ssol_1706
SSOA: SULA_1734
SSOL: SULB_1735
SSOF: SULC_1733
SAI: Saci_1623
SID: M164_1487
SII: LD85_1697
SIH: SiH_1456
SIR: SiRe_1366
SIC: SiL_1369
MSE: Msed_1993
MCN: Mcup_0293
AHO: Ahos_1103
 » show all
Taxonomy
Reference
1  [PMID:8354269]
  Authors
Strauss G, Fuchs G
  Title
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
  Journal
Eur J Biochem 215:633-43 (1993)
DOI:10.1111/j.1432-1033.1993.tb18074.x
Reference
2  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
3  [PMID:11948153]
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002
  Sequence
[cau:Caur_2614]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.298
IUBMB Enzyme Nomenclature: 1.1.1.298
ExPASy - ENZYME nomenclature database: 1.1.1.298
BRENDA, the Enzyme Database: 1.1.1.298

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