KEGG   ENZYME: 1.1.1.302Help
Entry
EC 1.1.1.302                Enzyme                                 

Name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase;
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase;
MjaRED;
MJ0671 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+ [RN:R09375 R09376]
Reaction(KEGG)
Substrate
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one [CPD:C18910];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC 1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1].
History
EC 1.1.1.302 created 2010, modified 2011
Pathway
ec00740  Riboflavin metabolism
ec01100  Metabolic pathways
Orthology
K14654  2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Genes
CME: CYME_CMQ053C
CCP: CHC_T00006214001
SCE: YBR153W(RIB7)
AGO: AGOS_AER037C
ERC: Ecym_5336
KLA: KLLA0_F21120g
KMX: KLMA_40225(RIB7)
LTH: KLTH0G15576g
VPO: Kpol_1053p40
ZRO: ZYRO0B06028g
NCS: NCAS_0I02380(NCAS0I02380)
NDI: NDAI_0A06950(NDAI0A06950)
TPF: TPHA_0A00760(TPHA0A00760)
TBL: TBLA_0F01170(TBLA0F01170)
TDL: TDEL_0D05100(TDEL0D05100)
KAF: KAFR_0G01390(KAFR0G01390)
SPAA: SPAPADRAFT_71929(RIB7)
CAL: CAALFM_C112810WA(CaO19.6341)
CAUR: QG37_00137
SLB: AWJ20_3203(RIB7)
NCR: NCU08313
NTE: NEUTE1DRAFT60176(NEUTE1DRAFT_60176)
MGR: MGG_12162
SSCK: SPSK_03569
CMT: CCM_05336
BFU: BCIN_09g06970(Bcrib7)
MBE: MBM_02523
ANI: AN6979.2
ANG: ANI_1_1020124(An14g00090) ANI_1_2310014(An01g01960)
ABE: ARB_06025
TVE: TRV_01178
PTE: PTT_14981
CNB: CNBA6060
ABP: AGABI1DRAFT67276(AGABI1DRAFT_67276)
ABV: AGABI2DRAFT213834(AGABI2DRAFT_213834)
MGL: MGL_2361
RGE: RGE_09730(ribD)
MJA: MJ_0671
MMP: MMP1348
MMD: GYY_07565
MAE: Maeo_0660
MVO: Mvol_0148
MTH: MTH_235
MMG: MTBMA_c06840(ribD)
METC: MTCT_0197
METE: tca_00215(ribD2)
MST: Msp_1185
MSI: Msm_0065
MRU: mru_1007(ribD)
MEB: Abm4_0661(ribD)
MMIL: sm9_1007(ribD)
MEYE: TL18_05380
MOL: YLM1_0551
MFC: BRM9_1623(ribD1) BRM9_2175(ribD2)
MFV: Mfer_0597
MKA: MK0098(ribD)
AFU: AF_2007
FPL: Ferp_1264
GAC: GACE_1041
GAH: GAH_01541
FAI: FAD_1195
CDIV: CPM_0367
MEAR: Mpt1_c11210(arfC)
MARC: AR505_1602
ABI: Aboo_0416
MAC: MA_4092(ribD) MA_4367(ribD)
MBU: Mbur_2352
MMH: Mmah_1489
MPY: Mpsy_2065
MTP: Mthe_0604
MCJ: MCON_0173(ribD)
MHI: Mhar_1003
MEMA: MMAB1_0301 MMAB1_1511(ribD)
RCI: LRC156(ribD) RRC489
HAL: VNG_1256G(ribG)
HSL: OE_2802F(ribG)
HHB: Hhub_2572(ribG)
HALH: HTSR_0741(ribD2)
HHSR: HSR6_0767(ribG)
HSU: HLASF_1655(ribD1)
HSF: HLASA_1642(ribD1)
HMA: rrnAC1131(ribG)
HHI: HAH_1738(ribG)
NPH: NP_2672A(arfC)
NMO: Nmlp_2212(ribG)
HUT: Huta_0543
HTI: HTIA_2649
HMU: Hmuk_2416
HWA: HQ_2510A(arfC)
HWC: Hqrw_2809(arfC)
HVO: HVO_1341(ribG)
HME: HFX_1418(ribG)
HLA: Hlac_0451
HTU: Htur_5200
NMG: Nmag_3078(ribG)
NAT: NJ7G_1457
SALI: L593_07135
ACJ: ACAM_0812
SMR: Smar_0461
IHO: Igni_0956
IIS: EYM_00140
HBU: Hbut_0557
STO: STK_02850
SSO: SSO2097(ribD)
SOL: Ssol_2812
SSOA: SULA_2833
SSOL: SULB_2834
SSOF: SULC_2831
SAI: Saci_2164(rib7)
SID: M164_0517
SII: LD85_0432
SIH: SiH_0852
SIR: SiRe_0492
SIC: SiL_0521
MSE: Msed_0021
MCN: Mcup_0021
AHO: Ahos_0760
PAI: PAE2985
PIS: Pisl_0385
PCL: Pcal_1122
PAS: Pars_1352
PYR: P186_1547
POG: Pogu_0862
TNE: Tneu_1742
CMA: Cmaq_1962
TUZ: TUZN_0676
TTN: TTX_1010(ribD)
VDI: Vdis_2227
VMO: VMUT_0666
ASC: ASAC_1153
ACIA: SE86_06920
NMR: Nmar_1612
NID: NPIRD3C_0441(ribD)
NCT: NMSP_1553(arfC)
NGA: Ngar_c32620(ribD)
NVN: NVIE_021910(ribD)
NEV: NTE_03545
TAA: NMY3_03743(ribD2)
NCV: NCAV_0047
NBV: T478_1325
NDV: NDEV_1966(arfC)
 » show all
Taxonomy
Reference
1  [PMID:11889103]
  Authors
Graupner M, Xu H, White RH
  Title
The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin.
  Journal
J Bacteriol 184:1952-7 (2002)
DOI:10.1128/JB.184.7.1952-1957.2002
  Sequence
[mja:MJ_0671]
Reference
2  [PMID:16730025]
  Authors
Chatwell L, Krojer T, Fidler A, Romisch W, Eisenreich W, Bacher A, Huber R, Fischer M
  Title
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
  Journal
J Mol Biol 359:1334-51 (2006)
DOI:10.1016/j.jmb.2006.04.045
  Sequence
[mja:MJ_0671]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.302
IUBMB Enzyme Nomenclature: 1.1.1.302
ExPASy - ENZYME nomenclature database: 1.1.1.302
BRENDA, the Enzyme Database: 1.1.1.302

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