KEGG   ENZYME: 1.1.1.303Help
Entry
EC 1.1.1.303                Enzyme                                 

Name
diacetyl reductase [(R)-acetoin forming];
(R)-acetoin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-acetoin:NAD+ oxidoreductase
Reaction(IUBMB)
(R)-acetoin + NAD+ = diacetyl + NADH + H+ [RN:R02855]
Reaction(KEGG)
Substrate
(R)-acetoin [CPD:C00810];
NAD+ [CPD:C00003]
Product
diacetyl [CPD:C00741];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76). While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible. This enzyme has been reported in the yeast Saccharomyces cerevisiae [1,2]. Different from EC 1.1.1.304, diacetyl reductase [(S)-acetoin forming].
History
EC 1.1.1.303 created 2010 (EC 1.1.1.5 created 1961, modified 1976, part incorporated 2010)
Pathway
ec00650  Butanoate metabolism
Orthology
K00004  (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase
Genes
SCE: YAL060W(BDH1) YAL061W(BDH2)
KLA: KLLA0_F00506g KLLA0_F00528g
KMX: KLMA_50016(BDH1) KLMA_50017(BDH2)
LTH: KLTH0D00616g
VPO: Kpol_1049p18
CGR: CAGL0D00198g
NCS: NCAS_0A07660(NCAS0A07660) NCAS_0A07670(NCAS0A07670)
NDI: NDAI_0H02050(NDAI0H02050) NDAI_0H02060(NDAI0H02060)
TPF: TPHA_0H03100(TPHA0H03100)
TBL: TBLA_0A04290(TBLA0A04290)
TDL: TDEL_0H04460(TDEL0H04460)
KAF: KAFR_0I00160(KAFR0I00160) KAFR_0I00170(KAFR0I00170)
PIC: PICST_89701(SOR1)
MBE: MBM_08711
ANI: AN9288.2
SRL: SOD_c19030(gutB) SOD_c29300(bdhA)
ETA: ETA_13710(adhB)
EPY: EpC_14410(adhB)
EPR: EPYR_01540(adhB)
EAM: EAMY_2196(adhB)
EAY: EAM_2119
ERJ: EJP617_32530(adhB)
PAU: PA14_10230(adh) PA14_10900(ydjL)
PNC: NCGM2_5301(ydjL) NCGM2_5356(adh)
PAEB: NCGM1900_0803(adh) NCGM1900_0860(ydjL)
PPU: PP_0552(bdhA)
PPF: Pput_0591
PPT: PPS_0549
PPI: YSA_06132
PPX: T1E_1534(bdhA)
PPUH: B479_03270
PPUT: L483_02890
PPUN: PP4_06240
PPUD: DW66_0566
PMON: X969_01185
PMOT: X970_01175
PPRC: PFLCHA0_c22200(bdhA1) PFLCHA0_c33950(bdhA2)
PSZ: PSTAB_2900(gutB)
PSR: PSTAA_3015(gutB)
PSEM: TO66_17355
AVN: Avin_41760(adh)
AVL: AvCA_41760(adh)
AVD: AvCA6_41760(adh)
ACX: Achr_8720(adh)
PALI: A3K91_1253
ACB: A1S_1705
ABM: ABSDF1934
ABY: ABAYE1943
ABN: AB57_1933
ABB: ABBFA_001791(gutB)
ABX: ABK1_2199
ABH: M3Q_2091
ABAD: ABD1_16970
ABAZ: P795_8705
ABAU: IX87_19415
ABAA: IX88_10480
ACC: BDGL_001066(bdh1)
ACI: ACIAD1021
ASJ: AsACE_p100043(bdhA)
MBS: MRBBS_2889(bdhA)
CYQ: Q91_0877
HAM: HALO2111
HBE: BEI_1438
ADI: B5T_00308
AXE: P40_01460
SALN: SALB1_2588
NME: NMB0604
NMP: NMBB_0667
NMH: NMBH4476_1586(gutB)
NMD: NMBG2136_0542(gutB)
NMM: NMBM01240149_1491(gutB)
NMS: NMBM01240355_0606(gutB)
NMA: NMA0808
NMW: NMAA_0457
NMX: NMA510612_0907(tdh)
NMC: NMC0547
NMN: NMCC_0550
NMT: NMV_1808
NMI: NMO_0489(tdh)
NGO: NGO0186
NGK: NGK_0240
NLA: NLA_16290
ECOR: SAMEA4412678_1404(gutB_1)
PSE: NH8B_2455
BVE: AK36_3830
BCJ: BCAM0035 BCAM1704(adh)
BCEW: DM40_4536
BCEO: I35_4035(tdh) I35_5575(adh)
BMUL: NP80_4483
BCT: GEM_3936
BDL: AK34_3888
BLAT: WK25_25120
BTEI: WS51_06130
BSTG: WT74_27610
BUK: MYA_4156
AAA: Acav_3447
DAC: Daci_2959
CTES: O987_13315
PCA: Pcar_0330(budX)
PPD: Ppro_1043
DPI: BN4_20346(bdhA)
SMD: Smed_4034
EAD: OV14_b0061(tdh)
AVI: Avi_7649
SHZ: shn_23065
OAH: DR92_2905
PDE: Pden_4980
PAMN: pAMV3p0150(bdhA)
DSH: Dshi_4159
SPHM: G432_04650
SPKC: KC8_08215
SSY: SLG_24940
SPHB: EP837_02951(butB)
AAY: WYH_01550(gutB)
ACR: Acry_2976
GXL: H845_1131
AZL: AZL_009040(gutB)
BSU: BSU06240(bdhA)
BSR: I33_0707
BSL: A7A1_0014
BSH: BSU6051_06240(bdhA)
BSUT: BSUB_00691(bdhA)
BSUL: BSUA_00691(bdhA)
BSUS: Q433_03525
BSS: BSUW23_03150(bdhA)
BST: GYO_0880
BSO: BSNT_06992(ydjL)
BSQ: B657_06240(bdhA)
BSX: C663_0642(bdhA)
BAY: RBAM_006650(ydjL)
BAQ: BACAU_0162(gutB1) BACAU_0636(bdhA1)
BYA: BANAU_0161(gutB1) BANAU_0576(bdhA)
BAML: BAM5036_0166(gutB) BAM5036_0585(bdhA)
BAMA: RBAU_0642(bdhA)
BAMN: BASU_0171(gutB1) BASU_0613(bdhA)
BAMB: BAPNAU_0162(gutB1) BAPNAU_0584(bdhA)
BAMT: AJ82_03695
BAMY: V529_05910(ydjL)
BMP: NG74_00192(gutB_1) NG74_00645(gutB_3)
BAO: BAMF_0161(gutB1) BAMF_0617(bdhA) BAMF_1833(gutB5)
BAZ: BAMTA208_00810(gutB1) BAMTA208_02880(bdhA) BAMTA208_08315(gutB5)
BQL: LL3_00661(bdhA) LL3_01924(gutB)
BXH: BAXH7_00164(gutB1) BAXH7_00605(ydjL) BAXH7_01695(gutB3)
BQY: MUS_0631(ydjL)
BHA: BH3949
BAN: BA_0675
BAR: GBAA_0675
BAT: BAS0641
BAI: BAA_0758
BANT: A16_07380
BANR: A16R_07440
BANS: BAPAT_0652
BANV: DJ46_5133
BCE: BC0668
BCA: BCE_0742 BCE_3248(gutB)
BCQ: BCQ_0741(adhB)
BCF: bcf_03455
BTK: BT9727_0585(adhB)
BTL: BALH_0616
BTT: HD73_0747
BTHI: BTK_03815
BTM: MC28_5399
BTG: BTB_c06890(bdhA)
BTI: BTG_17785
BTW: BF38_1920
BWW: bwei_4923(adhB)
BMYO: BG05_5251
BMYC: DJ92_3265
BCL: ABC0235
BPU: BPUM_2347
BPUM: BW16_12755
BPUS: UP12_11840
BMQ: BMQ_1884(bdhA)
BMD: BMD_1877(bdhA)
BMEG: BG04_4217
BAG: Bcoa_1775
BCOA: BF29_1719
BJS: MY9_0695
BACW: QR42_11925
BACY: QF06_02030
BACL: BS34A_07160(bdhA)
BALM: BsLM_0651
BGY: BGLY_0747
BBEV: BBEV_2737(bdhA)
OIH: OB3353
ANM: GFC28_352
AXL: AXY_04200
VPN: A21D_02492(gutB_1) A21D_03866(gutB_2)
BSE: Bsel_0599
SEP: SE2019
SER: SERP2032
SEPP: SEB_02026
SEPS: DP17_964
SHA: SH0605
SCA: SCA_2335(gutB)
SPAS: STP1_1419
SCAP: AYP1020_1631(gutB)
SSCH: LH95_01035
SSCZ: RN70_01255
BBE: BBR47_14610(ydjL)
PPY: PPE_03421
PPM: PPSC2_18175(adhB1)
PPO: PPM_3657(adhB1)
PPOL: X809_34265
PPOY: RE92_19025
LLA: L117145(butB)
LLK: LLKF_0924(butB)
LLS: lilo_0847(butB)
LLX: NCDO2118_0916(butB)
LLM: llmg_1642(butB)
LLJ: LG36_1429(butB)
SNT: SPT_0472
SND: MYY_0504
SPNN: T308_02110
SPP: SPP_0466
SSA: SSA_0572
SGO: SGO_0440
SCF: Spaf_1654
STJ: SALIVA_1693(gutB)
SSAH: HSISS4_01535(adhB2)
SIE: SCIM_1277
SIB: SIR_1468
SIU: SII_1455
LFE: LAF_0943
LFR: LC40_0618
LFF: LBFF_1013
LBH: Lbuc_2009
LAE: LBAT_1588
LME: LEUM_0912
LMM: MI1_04285
LMK: LMES_0836
LCI: LCK_00755
LKI: LKI_10090
LGS: LEGAS_1018(bdhA)
WCE: WS08_0968
WCT: WS74_1034
CBO: CBO2217
CBA: CLB_2156
CBY: CLM_2420
CBL: CLK_1657
CBK: CLL_A0664
CBB: CLD_2359
CBI: CLJ_B2427
CBT: CLH_0625
CBF: CLI_2266
CBM: CBF_2254
CBE: Cbei_1464
CBZ: Cbs_1464
CBEI: LF65_01539
CSB: CLSA_c40760(bdhA)
CLD: CLSPO_c22610(bdhA2)
CACE: CACET_c04920(bdhA)
CTYK: CTK_C16260
TPZ: Tph_c19660(bdhA)
MVA: Mvan_0788
MGI: Mflv_0125
MVQ: MYVA_0619
ASD: AS9A_4240
CDI: DIP2135
CDIP: ERS451417_02172(gutB)
CGY: CGLY_10510(bdhA)
NFA: NFA_30750
NFR: ERS450000_00990(gutB_1)
RER: RER_40280
REY: O5Y_18700
ROP: ROP_13310
REQ: REQ_44040
RFA: A3L23_01000(gutB_1) A3L23_02473 A3L23_03388(gutB_5) A3L23_03391(gutB_6)
RHU: A3Q40_01823(gutB_1)
GBR: Gbro_3625
SHY: SHJG_2464
SLAU: SLA_0209
ART: Arth_0880
ARM: ART_3026
AAI: AARI_31390(bdh)
KRH: KRH_22550
JDE: Jden_0784
BLIN: BLSMQ_1383
NML: Namu_1092
MMAR: MODMU_3886
AMN: RAM_36565
AMM: AMES_7013
AMZ: B737_7013
AMQ: AMETH_0716(adh) AMETH_1830(adh) AMETH_3638(adh)
PDX: Psed_3714
PSEE: FRP1_09150
PSEH: XF36_11545
ACTI: UA75_15100
ACAD: UA74_14510
AHG: AHOG_13650(gutB)
BAST: BAST_0421
LBA: Lebu_1842
MPW: MPR_2670
THS: TES1_0121
LOKI: Lokiarch_16160(gutB_1)
 » show all
Taxonomy
Reference
1  [PMID:2222122]
  Authors
Heidlas J, Tressl R
  Title
Purification and characterization of a (R)-2,3-butanediol dehydrogenase from Saccharomyces cerevisiae.
  Journal
Arch Microbiol 154:267-73 (1990)
Reference
2  [PMID:10938079]
  Authors
Gonzalez E, Fernandez MR, Larroy C, Sola L, Pericas MA, Pares X, Biosca JA
  Title
Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene.
  Journal
J Biol Chem 275:35876-85 (2000)
DOI:10.1074/jbc.M003035200
  Sequence
[sce:YAL060W]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.303
IUBMB Enzyme Nomenclature: 1.1.1.303
ExPASy - ENZYME nomenclature database: 1.1.1.303
BRENDA, the Enzyme Database: 1.1.1.303

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