KEGG   ENZYME: 1.1.1.306Help
Entry
EC 1.1.1.306                Enzyme                                 

Name
S-(hydroxymethyl)mycothiol dehydrogenase;
NAD/factor-dependent formaldehyde dehydrogenase;
mycothiol-dependent formaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
S-(hydroxymethyl)mycothiol:NAD+ oxidoreductase
Reaction(IUBMB)
S-(hydroxymethyl)mycothiol + NAD+ = S-formylmycothiol + NADH + H+ [RN:R09129]
Reaction(KEGG)
R09129;
(other) R10301
Show
Substrate
S-(hydroxymethyl)mycothiol [CPD:C18235];
NAD+ [CPD:C00003]
Product
S-formylmycothiol [CPD:C06718];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase.
History
EC 1.1.1.306 created 2010 as EC 1.2.1.66, transferred 2010 to EC 1.1.1.306
Orthology
K00153  S-(hydroxymethyl)mycothiol dehydrogenase
Genes
RED: roselon_02447
MALG: MALG_00612
THAS: C6Y53_10760
MTU: Rv2259(mscR)
MTV: RVBD_2259
MTC: MT2320
MRA: MRA_2280(adhE2)
MTF: TBFG_12287
MTB: TBMG_01722
MTK: TBSG_01732
MTUR: CFBS_2392(adhE2)
MTO: MTCTRI2_2295(adhE2)
MTD: UDA_2259(adhE2)
MTN: ERDMAN_2484(adhE2)
MTUB: MT7199_2291(mscR)
MTUC: J113_15745
MTUE: J114_12115
MTUL: TBHG_02210
MTUT: HKBT1_2383(adhE2)
MTUU: HKBT2_2385(adhE2)
MTQ: HKBS1_2389(adhE2)
MBO: BQ2027_MB2283(mscr)
MBB: BCG_2277(adhE2)
MBT: JTY_2271(adhE2)
MBM: BCGMEX_2265(adhE2)
MBX: BCGT_2082
MAF: MAF_22700(adhE2)
MMIC: RN08_2508
MCE: MCAN_22841(adhE2)
MCQ: BN44_50206(mscR)
MCV: BN43_31502(mscR)
MCX: BN42_40181(mscR)
MCZ: BN45_50590(mscR)
MLE: ML1784(adhE2)
MLB: MLBr01784(adhE2)
MPA: MAP_2008(adhE2)
MAO: MAP4_1817
MAVI: RC58_09075
MAVU: RE97_09080
MIT: OCO_21650
MIA: OCU_21830
MID: MIP_03062
MYO: OEM_19560
MIR: OCQ_20750
MUL: MUL_1292(adhE2)
MMC: Mmcs_3380
MKM: Mkms_3442
MJL: Mjls_3391
MMI: MMAR_3350(adhE2)
MMAE: MMARE11_32510(adhE2)
MMM: W7S_10175
MLI: MULP_03613(adhE2)
MHAD: B586_09845
MSG: MSMEI_4240(adhE2)
MVA: Mvan_3767
MGI: Mflv_2766
MVQ: MYVA_3590
MTHN: 4412656_01773(adhE2)
MAB: MAB_1869c
MABB: MASS_1856
MSTE: MSTE_01788
MJD: JDM601_1636(adhE2)
MTER: 4434518_01553(adhE2)
ASD: AS9A_2336
CGL: NCgl0313(Cgl0319)
CGB: cg0387(adhE)
CGU: WA5_0313
CGT: cgR_0403
CGM: cgp_0387
CGJ: AR0_01965
CEF: CE0330
CJK: jk0636
CUR: cu1315(mscR)
CUA: CU7111_1296(mscR)
CAR: cauri_0242(mscR)
CRD: CRES_0702
CVA: CVAR_1075
CTER: A606_04230
COA: DR71_404
CSP: WM42_1115
CAQU: CAQU_07950
CAMG: CAMM_01775
CMIN: NCTC10288_02284(mscR)
NFA: NFA_12230
RER: RER_54700(adhC)
REY: O5Y_26055
ROP: ROP_23120(adhC)
REQ: REQ_39460(mscR)
RHB: NY08_1256
GBR: Gbro_0092
GOR: KTR9_0076
TPR: Tpau_0408
SCO: SCO0741(3SC5B7.19c)
SALB: XNR_5600
SMA: SAVERM_6953(adhA10)
SGR: SGR_5824
SGB: WQO_06170
SCB: SCAB_7101(adhC) SCAB_8471
SCT: SCAT_0660(frmA)
SFA: Sfla_5154
SVE: SVEN_1275
STRP: F750_1483(mscR)
SFI: SFUL_1200
STRM: M444_30650
SPRI: SPRI_5868
SLE: sle_05100(sle_05100)
STRD: NI25_02340
SLAU: SLA_1217
SALJ: SMD11_5967
KSK: KSE_06610
ART: Arth_3723
ARM: ART_1004
AAU: AAur_2317(adhE2)
ACH: Achl_3472
KRH: KRH_10130
LMOI: VV02_07330
SERJ: SGUI_2619
BLIN: BLSMQ_3280
MPH: MLP_03010
NCA: Noca_3651
NDK: I601_0344
KFL: Kfla_2454
NDA: Ndas_2396
NAL: B005_4263
TCU: Tcur_2454
SRO: Sros_1329
FAL: FRAAL2245
NML: Namu_1341
GOB: Gobs_4761
MMAR: MODMU_5128
KRA: Krad_0910
AMD: AMED_8415
AMN: RAM_43205
AMM: AMES_8286
AMZ: B737_8287
PDX: Psed_0641
PSEA: WY02_19430
PSEE: FRP1_23400
PSEH: XF36_22035
AMI: Amir_3767
SESP: BN6_44780
KAL: KALB_654
ACTI: UA75_11410
ACAD: UA74_11325
MIL: ML5_5136
ASE: ACPL_1152(adhC)
ACTN: L083_1258
AFS: AFR_06250
ACTS: ACWT_1033
CAI: Caci_4165
SNA: Snas_1403
 » show all
Taxonomy
Reference
1  [PMID:9202149]
  Authors
Misset-Smits M, van Ophem PW, Sakuda S, Duine JA.
  Title
Mycothiol, 1-O-(2'-[N-acetyl-L-cysteinyl]amido-2'-deoxy-alpha-D-glucopyranosyl)-D- myo-inositol, is the factor of NAD/factor-dependent formaldehyde dehydrogenase.
  Journal
FEBS Lett 409:221-2 (1997)
DOI:10.1016/S0014-5793(97)00510-3
Reference
2  [PMID:9346279]
  Authors
Norin A, Van Ophem PW, Piersma SR, Persson B, Duine JA, Jornvall H.
  Title
Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaroytic alcohol dehydrogenases--primary structure, conformational modelling and functional correlations.
  Journal
Eur J Biochem 248:282-9 (1997)
DOI:10.1111/j.1432-1033.1997.00282.x
  Sequence
Reference
3  [PMID:12809551]
  Authors
Vogt RN, Steenkamp DJ, Zheng R, Blanchard JS.
  Title
The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase.
  Journal
Biochem J 374:657-66 (2003)
DOI:10.1042/BJ20030642
  Sequence
[mtu:Rv2259]
Reference
4  [PMID:17286835]
  Authors
Rawat M, Av-Gay Y
  Title
Mycothiol-dependent proteins in actinomycetes.
  Journal
FEMS Microbiol Rev 31:278-92 (2007)
DOI:10.1111/j.1574-6976.2006.00062.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.306
IUBMB Enzyme Nomenclature: 1.1.1.306
ExPASy - ENZYME nomenclature database: 1.1.1.306
BRENDA, the Enzyme Database: 1.1.1.306
CAS: 192140-85-5

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