KEGG   ENZYME: 1.1.1.308Help
Entry
EC 1.1.1.308                Enzyme                                 

Name
sulfopropanediol 3-dehydrogenase;
DHPS 3-dehydrogenase (sulfolactate forming);
2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming);
dihydroxypropanesulfonate 3-dehydrogenase;
hpsN (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+ + H2O = (R)-3-sulfolactate + 2 NADH + 2 H+ [RN:R09545]
Reaction(KEGG)
Substrate
(R)-2,3-dihydroxypropane-1-sulfonate [CPD:C19675];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
(R)-3-sulfolactate [CPD:C11537];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.
History
EC 1.1.1.308 created 2011
Orthology
K15509  sulfopropanediol 3-dehydrogenase
Genes
ECLO: ENC_28830
ECLX: LI66_17165 LI66_17190
ECLY: LI62_18750 LI62_18775
EXF: BFV63_16780 BFV63_16805
ECAN: CWI88_05315(hisD) CWI88_05340(hisD)
EAE: EAE_05825
EAR: CCG32834
GQU: AWC35_21415
LAX: APT61_12775 APT61_12800
LEI: C2U54_14965(hisD) C2U54_14990(hisD)
LEH: C3F35_01725(hisD)
LEW: DAI21_16950(hisD)
VCA: M892_00680(hisD)
VAG: N646_3369
GHO: AL542_00750(hisD) AL542_03485(hisD)
PFS: PFLU_1949
PSYC: DABAL43B_1044(hisD1)
ABAU: IX87_19995
PART: PARC_a1302(hpsN)
AMAC: MASE_15385
GPS: C427_0082
GAI: IMCC3135_20750(hpsN_1) IMCC3135_26035(hpsN_2) IMCC3135_30885(hpsN_3)
HCO: LOKO_03376(hpsN)
HHH: CLM76_02795(hisD)
HBE: BEI_0845(hpsN1) BEI_1107(hpsN2)
HAF: C8233_03385(hisD)
SALN: SALB1_1666
REH: H16_A1694(h16_A1694)
BCN: Bcen_1517
BGO: BM43_40(hisD)
BGP: BGL_2c18430(hisD)
BXE: Bxe_C0309
BXB: DR64_8125(hisD)
BPH: Bphy_7422
BHZ: ACR54_00804(hpsN)
BTRM: SAMEA390648700451(hisD_1)
AXY: AXYL_01399(hisD2)
ASW: CVS48_08695(hisD)
AMIM: MIM_c09530(hisD2)
VEI: Veis_0769
RTA: Rta_27270(hisD)
LIH: L63ED372_00902(hpsN)
ACOM: CEW83_08425(hisD)
DAT: HRM2_03140(hisD1)
MLO: mlr6649
MES: Meso_1928
SMD: Smed_4290
SFH: SFHH103_01284(hisD2)
SIX: BSY16_5513(hisD)
SAME: SAMCFNEI73_pC1468(hisD)
EAD: OV14_b0880(hisD1)
REI: IE4771_PB00243(hisD-2)
RLE: pRL80041(hisD2)
BOS: BSY19_1289(hisD)
VGO: GJW-30_1_00907(hpsN_1) GJW-30_1_01965(hpsN_2)
MNO: Mnod_4267
DEI: C4375_12335(hisD) C4375_12360(hisD)
MMED: Mame_04313(hpsN_1) Mame_05173(hpsN_2) Mame_05185(hpsN_3)
BRN: D1F64_19415(hisD)
HDI: HDIA_3170(hpsN)
SIL: SPO0594(hpsN) SPO0981
RUE: DT065_17120(hisD)
RUA: D1823_05095(hisD) D1823_18835(hisD)
RDE: RD1_3808(hisD) RD1_3948(hisD)
RLI: RLO149_c004880(hisD2) RLO149_c006370(hisD3)
PYE: A6J80_16310(hisD) A6J80_16410(hisD)
PZH: CX676_13155(hisD) CX676_13200(hisD)
PARO: CUV01_13375(hisD) CUV01_13420(hisD)
PARU: CYR75_12595(hisD)
DSH: Dshi_2034(hisD2) Dshi_2242(hisD3)
PGA: PGA1_c07750(hisD1) PGA1_c25490(hisD2) PGA1_c27370(hisD3)
PGL: PGA2_c07530(hisD2) PGA2_c25390(hisD3)
PHP: PhaeoP97_01086(hisD3)
PPIC: PhaeoP14_00696(hisD1) PhaeoP14_02480(hisD3)
PHQ: D1820_08400(hisD) D1820_16950(hisD)
OAT: OAN307_c35180(hisD2) OAN307_c48490(hisD3)
OAR: OA238_160p0290(hisD) OA238_c24160(hisD1) OA238_c29640(hisD2) OA238_c48370(hisD4)
OTM: OSB_32490(hpsN)
PTP: RCA23_c21930(hisD2) RCA23_c26870(hisD3)
RSU: NHU_04453(hisD)
LABR: CHH27_12040(hisD) CHH27_16760(hisD)
YPAC: CEW88_04375(hisD) CEW88_22695(hisD)
SULZ: C1J03_04920(hisD) C1J03_11915(hisD)
SULI: C1J05_06910(hisD) C1J05_16090(hisD)
RBG: BG454_15370(hisD)
SAGU: CDO87_14620(hisD) CDO87_18475(hisD) CDO87_18520(hisD)
THAS: C6Y53_06700(hisD)
GEH: HYN69_00370(hisD)
NAR: Saro_3423
NOV: TQ38_020025(hisD)
SPHI: TS85_23210
SPHR: BSY17_83(hisD)
BLAS: BSY18_3965(hisD)
RDI: CMV14_09780(hisD)
THAC: CSC3H3_22895(hisD)
NAO: Y958_19140(hisD)
NCB: C0V82_13695(hisD)
PUB: SAR11_0801(hisD2)
BCL: ABC1168
BMD: BMD_1657(hisD)
BMEG: BG04_3973(hisD)
BEO: BEH_11410
BKO: CKF48_05215(hisD)
SSCU: CEP64_13375(hisD)
PLX: CW734_04305(hisD)
TAE: TepiRe1_1115(hisD)
MSM: MSMEG_2012(hisD) MSMEG_5656(hisD)
MVQ: MYVA_3092(hisD2)
CGT: cgR_0116
CGY: CGLY_10805(hisD1) CGLY_10865(hpsN)
RHA: RHA1_ro04557(hisD2)
ROP: ROP_44710(hisD)
SCB: SCAB_89041(hisD)
SMAL: SMALA_1386
ARTH: C3B78_17490(hisD)
KRA: Krad_2498
SEN: SACE_3119(hisD2)
AMYC: CU254_18835(hisD) CU254_18870(hisD)
PSEA: WY02_28305
CWO: Cwoe_0128
MRB: Mrub_2545
PLH: VT85_11070(hpsN)
SACI: Sinac_7380
PBOR: BSF38_01252(hpsN)
RUN: DR864_23085(hisD)
 » show all
Taxonomy
Reference
1  [PMID:20150239]
  Authors
Mayer J, Huhn T, Habeck M, Denger K, Hollemeyer K, Cook AM
  Title
2,3-Dihydroxypropane-1-sulfonate degraded by Cupriavidus pinatubonensis JMP134: purification of dihydroxypropanesulfonate 3-dehydrogenase.
  Journal
Microbiology 156:1556-64 (2010)
DOI:10.1099/mic.0.037580-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.308
IUBMB Enzyme Nomenclature: 1.1.1.308
ExPASy - ENZYME nomenclature database: 1.1.1.308
BRENDA, the Enzyme Database: 1.1.1.308

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