KEGG   ENZYME: 1.1.1.310Help
Entry
EC 1.1.1.310                Enzyme                                 

Name
(S)-sulfolactate dehydrogenase;
(2S)-3-sulfolactate dehydrogenase;
SlcC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S)-sulfolactate:NAD+ oxidoreductase
Reaction(IUBMB)
(2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+ [RN:R05693]
Reaction(KEGG)
Substrate
(2S)-3-sulfolactate [CPD:C11499];
NAD+ [CPD:C00003]
Product
3-sulfopyruvate [CPD:C05528];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase.
The enzyme is specific for NAD+.
History
EC 1.1.1.310 created 2011, modified 2013
Pathway
ec00270  Cysteine and methionine metabolism
Orthology
K16843  (S)-sulfolactate dehydrogenase
Genes
APRS: BI364_08725
CSA: Csal_1770
HBE: BEI_0838(slcC)
RPJ: N234_02635
REU: Reut_B3530
CUH: BJN34_26760
CTI: RALTA_B0841(serA2)
CBW: RR42_m0458
CGD: CR3_0183(slcC)
BXE: Bxe_B1896
BXB: DR64_7205
BPT: Bpet0409(serA2)
AXY: AXYL_00471(serA1)
AXX: ERS451415_00471(serA_1)
AMIM: MIM_c37610(serA2)
VEI: Veis_0891
HAR: HEAR3340
ADE: Adeh_1262
OCA: OCAR_7552
OCG: OCA5_c05880(serA1)
OCO: OCA4_c05870(serA1)
MET: M446_6454
MOR: MOC_4868
RVA: Rvan_3575
FIL: BN1229_v1_1881(slcC)
FIY: BN1229_v1_1884(slcC)
DSH: Dshi_1001(serA2)
RSU: NHU_04238
AZL: AZL_004920(serA)
TMR: Tmar_0517
SNA: Snas_1558
CAP: CLDAP_22200(serA)
MRB: Mrub_2461
 » show all
Taxonomy
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
[csa:Csal_1770]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.310
IUBMB Enzyme Nomenclature: 1.1.1.310
ExPASy - ENZYME nomenclature database: 1.1.1.310
BRENDA, the Enzyme Database: 1.1.1.310

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