KEGG   ENZYME: 1.1.1.312Help
Entry
EC 1.1.1.312                Enzyme                                 

Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase;
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase;
4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase;
alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase;
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase;
LigC;
ProD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
Reaction(IUBMB)
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+ [RN:R04279]
Reaction(KEGG)
Substrate
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal;
NADP+ [CPD:C00006]
Product
2-oxo-2H-pyran-4,6-dicarboxylate;
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
History
EC 1.1.1.312 created 1978 as EC 1.2.1.45, transferred 2011 to EC 1.1.1.312
Pathway
ec00350  Tyrosine metabolism
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Genes
VNA: PN96_18475
VEJ: VEJY3_18041
VFL: AL536_10275
PAT: Patl_3884
AAW: AVL56_08855
CSA: Csal_0286
MMW: Mmwyl1_3923
MME: Marme_0839
MPC: Mar181_0387
GSN: YC6258_04095
BPH: Bphy_3203
HYF: DTO96_100894(ligC)
AFQ: AFA_05510
RFR: Rfer_0329
PNA: Pnap_2026
ACRA: BSY15_1203
VEI: Veis_0171
DAC: Daci_4444
CTES: O987_16255
RTA: Rta_24750
LIM: L103DPR2_01499(ligC)
LIH: L63ED372_01146(ligC)
HYB: Q5W_10735
CBAA: SRAA_1349
CBAB: SMCB_0796
LCH: Lcho_3638
AZO: azo2536(ligC)
AOA: dqs_2693
TCL: Tchl_1063
BRA: BRADO2343(ligC)
BBT: BBta_2703(ligC)
AOL: S58_52560
BRO: BRAD285_4994(ligC)
RPA: RPA4703(ligC)
RPB: RPB_0871
RPD: RPD_0981
RPE: RPE_0752
RPT: Rpal_5184
MALG: MALG_02288
NAR: Saro_2811
SMAZ: LH19_17685
SPHI: TS85_18525
SSAN: NX02_17495
SSY: SLG_12490(ligC)
SPHB: EP837_03495(ligC)
SPHR: BSY17_3445
SFLA: SPHFLASMR4Y_02989(ligC)
BLAS: BSY18_3525
AAY: WYH_01910(ligC)
ADO: A6F68_01078(ligC)
MAG: amb0255
MAGX: XM1_1092(ligC)
MAGN: WV31_13620
ABS: AZOBR_p310194(ligC)
MAGQ: MGMAQ_2671(ligC)
SLAU: SLA_7099
KSK: KSE_75130(pcmB)
AMIN: AUMI_19370
AUW: AURUGA1_00421(ligC)
ART: Arth_4372
 » show all
Taxonomy
Reference
1  [PMID:26671]
  Authors
Maruyama K, Ariga N, Tsuda M, Deguchi K.
  Title
Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J Biochem (Tokyo) 83:1125-34 (1978)
Reference
2  [PMID:528534]
  Authors
Maruyama K
  Title
Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase.
  Journal
J Biochem 86:1671-7 (1979)
Reference
3  [PMID:6841353]
  Authors
Maruyama K.
  Title
Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
  Journal
J Biochem (Tokyo) 93:557-65 (1983)
Reference
4  [PMID:11073908]
  Authors
Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M
  Title
Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 182:6651-8 (2000)
DOI:10.1128/JB.182.23.6651-6658.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.312
IUBMB Enzyme Nomenclature: 1.1.1.312
ExPASy - ENZYME nomenclature database: 1.1.1.312
BRENDA, the Enzyme Database: 1.1.1.312

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