KEGG   ENZYME: 1.1.1.313Help
Entry
EC 1.1.1.313                Enzyme                                 

Name
sulfoacetaldehyde reductase;
isfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isethionate:NADP+ oxidoreductase
Reaction(IUBMB)
isethionate + NADP+ = 2-sulfoacetaldehyde + NADPH + H+ [RN:R02600]
Reaction(KEGG)
Substrate
isethionate [CPD:C05123];
NADP+ [CPD:C00006]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes that catalyse this reaction, a constitutive enzyme (encoded by isfD2) and an inducible enzyme (encoded by isfD). The latter is induced by taurine, and is responsible for most of the activity observed in taurine-grown cells.
History
EC 1.1.1.313 created 2011
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K15373  sulfoacetaldehyde reductase
Genes
ENR: H650_21530
ENF: AKI40_3718
KPN: KPN_00576
KPU: KP1_1516
KPM: KPHS_14060
KPP: A79E_3668
KPH: KPNIH24_21755
KPZ: KPNIH27_06510
KPV: KPNIH29_07210
KPW: KPNIH30_07240
KPT: VK055_1961(sdh)
KPE: KPK_4008
KPR: KPR_3984
KPJ: N559_3751
KPX: PMK1_02903(isfD)
KPNU: LI86_19240
KPNK: BN49_1630
KVA: Kvar_3797
KOX: KOX_13770
KOE: A225_1573
PPSE: BN5_0584
PSA: PST_4121
PSTT: CH92_10795
PSES: PSCI_0298
HAM: HALO0642
ODI: ODI_R0192
 » show all
Taxonomy
Reference
1  [PMID:20133363]
  Authors
Krejcik Z, Hollemeyer K, Smits TH, Cook AM
  Title
Isethionate formation from taurine in Chromohalobacter salexigens: purification of sulfoacetaldehyde reductase.
  Journal
Microbiology 156:1547-55 (2010)
DOI:10.1099/mic.0.036699-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.313
IUBMB Enzyme Nomenclature: 1.1.1.313
ExPASy - ENZYME nomenclature database: 1.1.1.313
BRENDA, the Enzyme Database: 1.1.1.313

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