KEGG   ENZYME: 1.1.1.315Help
Entry
EC 1.1.1.315                Enzyme                                 

Name
11-cis-retinol dehydrogenase;
RDH5 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
11-cis-retinol:NAD+ oxidoreductase
Reaction(IUBMB)
11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R03048 R08382
Show
Substrate
11-cis-retinol---[retinal-binding-protein];
NAD+ [CPD:C00003]
Product
11-cis-retinal---[retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].
History
EC 1.1.1.315 created 2011
Orthology
K00061  11-cis-retinol dehydrogenase
Genes
HSA: 5959(RDH5)
PTR: 467029(RDH5)
PPS: 100988391(RDH5)
GGO: 101125878(RDH5)
PON: 100437933(RDH5)
NLE: 100598708(RDH5)
MCC: 709644(RDH5)
MCF: 107126391(RDH5)
CSAB: 103238482(RDH5)
RRO: 104673711(RDH5)
RBB: 108516026(RDH5)
CJC: 100402026(RDH5)
SBQ: 101051979(RDH5)
MMU: 19682(Rdh5)
RNO: 366791(Rdh5)
CGE: 100772460(Rdh5)
NGI: 103738827(Rdh5)
HGL: 101701578(Rdh5)
CCAN: 109696229(Rdh5)
OCU: 100346443(RDH5)
TUP: 102492697(RDH5)
CFA: 481098(RDH5)
AML: 100477613(RDH5)
UMR: 103682388(RDH5)
ORO: 101378842(RDH5)
FCA: 101090450(RDH5)
PTG: 102955802(RDH5)
AJU: 106986902(RDH5)
BTA: 281448(RDH5)
BOM: 102281461(RDH5)
BIU: 109559397(RDH5)
PHD: 102319288(RDH5)
CHX: 102179453(RDH5)
OAS: 101115199(RDH5)
SSC: 100517586(RDH5)
CFR: 102522460(RDH5)
CDK: 105086399(RDH5)
BACU: 103013640(RDH5)
LVE: 103070515(RDH5)
OOR: 101272361(RDH5)
ECB: 100051379(RDH5)
EPZ: 103560206(RDH5)
EAI: 106841311(RDH5)
MYB: 102250054(RDH5)
MYD: 102752637(RDH5)
HAI: 109396898(RDH5)
RSS: 109452992(RDH5)
PALE: 102890960(RDH5)
LAV: 100665758(RDH5)
TMU: 101359207
SHR: 100926680(RDH5)
OAA: 100077776(RDH5)
GGA: 395452(RDH5)
MGP: 100551395(RDH5)
CJO: 107325819(RDH5)
PHI: 102110114(RDH5)
CLV: 102088293(RDH5)
ASN: 102385802(RDH5)
AMJ: 102572099(RDH5)
PSS: 102452664(RDH5)
CPIC: 101937595(RDH5)
ACS: 100557709 100561257(rdh5)
PVT: 110073773(RDH5)
PBI: 103065660(RDH5)
GJA: 107121726(RDH5)
XLA: 444623(rdh5.L) 447549(rdh5.S)
XTR: 496830(rdh5)
NPR: 108796498(RDH5)
DRE: 556528(rdh5)
SANH: 107653177
IPU: 108281000(rdh5)
AMEX: 103042897(rdh5)
LCO: 104922032(rdh5)
NCC: 104964277
MZE: 101481430
OLA: 100125503(rdh5)
XMA: 102227238
PRET: 103464826
NFU: 107385384(rdh5)
CSEM: 103386710(rdh5) 103399462
LCF: 108902106
HCQ: 109509231 109521663(rdh5)
BPEC: 110173750(rdh5)
SFM: 108927891 108928371(rdh5)
LCM: 102365116
CMK: 103180707(rdh5)
 » show all
Taxonomy
Reference
1  [PMID:7836368]
  Authors
Simon A, Hellman U, Wernstedt C, Eriksson U
  Title
The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.
  Journal
J Biol Chem 270:1107-12 (1995)
DOI:10.1074/jbc.270.3.1107
  Sequence
[bta:281448]
Reference
2  [PMID:9931293]
  Authors
Wang J, Chai X, Eriksson U, Napoli JL
  Title
Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.
  Journal
Biochem J 338 ( Pt 1):23-7 (1999)
  Sequence
[hsa:5959]
Reference
3  [PMID:11675386]
  Authors
Liden M, Romert A, Tryggvason K, Persson B, Eriksson U
  Title
Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.
  Journal
J Biol Chem 276:49251-7 (2001)
DOI:10.1074/jbc.M107337200
  Sequence
[hsa:5959]
Reference
4  [PMID:12536149]
  Authors
Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW
  Title
Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.
  Journal
J Biol Chem 278:12390-6 (2003)
DOI:10.1074/jbc.M212775200
  Sequence
[hsa:5959]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.315
IUBMB Enzyme Nomenclature: 1.1.1.315
ExPASy - ENZYME nomenclature database: 1.1.1.315
BRENDA, the Enzyme Database: 1.1.1.315

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