KEGG   ENZYME: 1.1.1.316Help
Entry
EC 1.1.1.316                Enzyme                                 

Name
L-galactose 1-dehydrogenase;
L-GalDH;
L-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ [RN:R07675]
Reaction(KEGG)
Substrate
L-galactose [CPD:C01825];
NAD+ [CPD:C00003]
Product
L-galactono-1,4-lactone [CPD:C01115];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+.
History
EC 1.1.1.316 created 2011
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17744  L-galactose dehydrogenase
Genes
ATH: AT4G33670
ALY: ARALYDRAFT_491313
CRB: 17878442
CSAT: 104716785 104721448 104729882
EUS: EUTSA_v10025723mg EUTSA_v10026635mg EUTSA_v10027595mg
BRP: 103834464 103862253(GDH)
BNA: 106405751 106423369 106441159
BOE: 106303708
THJ: 104807192
CPAP: 110818987
CIT: 102621043
TCC: 18607308
GRA: 105763009
DZI: 111308642
EGR: 104453016
VRA: 106765834
VAR: 108332744
CCAJ: 109809791
CAM: 101495571
LJA: Lj0g3v0243739.1(Lj0g3v0243739.1) Lj4g3v0410570.2(Lj4g3v0410570.2)
ADU: 107480539
AIP: 107626271
LANG: 109331942
FVE: 101299720
PPER: 18766583
PMUM: 103334968
PAVI: 110757233
MDM: 103436244
PXB: 103938180
ZJU: 107427462
CSV: 101206435
CMO: 103495364
MCHA: 111022462
CMAX: 111471025
CMOS: 111455013
CPEP: 111776398
RCU: 8279173
JCU: 105635996
JRE: 108995719
VVI: 100263479(GDH)
SLY: 101254135
SPEN: 107006598
SOT: 102599558
CANN: 107840121
NSY: 104219974
NTO: 104103548
INI: 109165254
SIND: 105169328
OEU: 111388928
HAN: 110877998
LSV: 111881024
CCAV: 112500306
DCR: 108224817
BVG: 104904801
SOE: 110788012
NNU: 104607573
OSA: 4352223
DOSA: Os12t0482700-01(Os12g0482700)
OBR: 102719064
BDI: 100840848
ATS: 109753847(LOC109753847) 109776045(LOC109776045)
SBI: 8063259
ZMA: 732776(pco064579)
SITA: 101762145
PDA: 103707620
EGU: 105055920
MUS: 103979808
DCT: 110113925
AOF: 109834292
ATR: 18442443
APRO: F751_2396
DFA: DFA_04455(alrE)
SPAR: SPRG_00672
ABAS: ACPOL_7179
 » show all
Taxonomy
Reference
1  [PMID:15509850]
  Authors
Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S
  Title
Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate.
  Journal
Plant Cell Physiol 45:1271-9 (2004)
DOI:10.1093/pcp/pch152
  Sequence
Reference
2  [PMID:12047629]
  Authors
Gatzek S, Wheeler GL, Smirnoff N
  Title
Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis.
  Journal
Plant J 30:541-53 (2002)
DOI:10.1046/j.1365-313X.2002.01315.x
  Sequence
[ath:AT4G33670]
Reference
3  [PMID:9620799]
  Authors
Wheeler GL, Jones MA, Smirnoff N
  Title
The biosynthetic pathway of vitamin C in higher plants.
  Journal
Nature 393:365-9 (1998)
DOI:10.1038/30728
Reference
4  [PMID:19297184]
  Authors
Oh MM, Carey EE, Rajashekar CB
  Title
Environmental stresses induce health-promoting phytochemicals in lettuce.
  Journal
Plant Physiol Biochem 47:578-83 (2009)
DOI:10.1016/j.plaphy.2009.02.008
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.316
IUBMB Enzyme Nomenclature: 1.1.1.316
ExPASy - ENZYME nomenclature database: 1.1.1.316
BRENDA, the Enzyme Database: 1.1.1.316

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