KEGG   ENZYME: 1.1.1.317Help
Entry
EC 1.1.1.317                Enzyme                                 

Name
perakine reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
raucaffrinoline:NADP+ oxidoreductase
Reaction(IUBMB)
raucaffrinoline + NADP+ = perakine + NADPH + H+ [RN:R09806]
Reaction(KEGG)
Substrate
raucaffrinoline [CPD:C19931];
NADP+ [CPD:C00006]
Product
perakine [CPD:C19932];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway. The enzyme is a member of the aldo-keto reductase enzyme superfamily from higher plants.
History
EC 1.1.1.317 created 2011
Orthology
K19639  perakine reductase
Reference
1  [PMID:18409028]
  Authors
Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stockigt J
  Title
Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia.
  Journal
Plant Mol Biol 67:455-67 (2008)
DOI:10.1007/s11103-008-9331-7
  Sequence
Reference
2  [PMID:17142919]
  Authors
Rosenthal C, Mueller U, Panjikar S, Sun L, Ruppert M, Zhao Y, Stockigt J
  Title
Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1286-9 (2006)
DOI:10.1107/S174430910605041X
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.317
IUBMB Enzyme Nomenclature: 1.1.1.317
ExPASy - ENZYME nomenclature database: 1.1.1.317
BRENDA, the Enzyme Database: 1.1.1.317

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