KEGG   ENZYME: 1.1.1.324Help
Entry
EC 1.1.1.324                Enzyme                                 

Name
8-hydroxygeraniol dehydrogenase;
8-hydroxygeraniol oxidoreductase;
CYP76B10;
G10H;
CrG10H;
SmG10H;
acyclic monoterpene primary alcohol:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(6E)-8-hydroxygeraniol:NADP+ oxidoreductase
Reaction(IUBMB)
(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction) [RN:R08499];
(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+ [RN:R09926];
(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+  [RN:R09927];
(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+  [RN:R09928];
(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:R09929]
Reaction(KEGG)
Substrate
(6E)-8-hydroxygeraniol [CPD:C17621];
NADP+ [CPD:C00006];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Product
(6E)-8-oxogeranial [CPD:C17622];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]
Comment
Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.
History
EC 1.1.1.324 created 2012
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:1864846]
  Authors
Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T.
  Title
Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols.
  Journal
J Biochem 109:341-7 (1991)
Reference
2  [PMID:7726550]
  Authors
Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG
  Title
Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa).
  Journal
Arch Biochem Biophys 318:105-12 (1995)
DOI:10.1006/abbi.1995.1210
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.324
IUBMB Enzyme Nomenclature: 1.1.1.324
ExPASy - ENZYME nomenclature database: 1.1.1.324
BRENDA, the Enzyme Database: 1.1.1.324

DBGET integrated database retrieval system