KEGG   ENZYME: 1.1.1.330Help
Entry
EC 1.1.1.330                Enzyme                                 

Name
very-long-chain 3-oxoacyl-CoA reductase;
very-long-chain 3-ketoacyl-CoA reductase;
very-long-chain beta-ketoacyl-CoA reductase;
KCR (gene name);
IFA38 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+ [RN:R10826]
Reaction(KEGG)
R10826;
(other) R07759
Show
Substrate
very-long-chain (3R)-3-hydroxyacyl-CoA [CPD:C20878];
NADP+ [CPD:C00006]
Product
very-long-chain 3-oxoacyl-CoA [CPD:C20877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
History
EC 1.1.1.330 created 2012
Pathway
ec00062  Fatty acid elongation
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K10251  17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Genes
HSA: 51144(HSD17B12)
PTR: 741010(HSD17B12)
PPS: 100971612(HSD17B12)
GGO: 101126579(HSD17B12)
PON: 100439025(HSD17B12)
NLE: 100600308(HSD17B12)
MCC: 106993263(HSD17B12)
MCF: 101867269(HSD17B12)
CSAB: 103237147(HSD17B12)
RRO: 104673891(HSD17B12)
RBB: 108519261(HSD17B12)
CJC: 100399351(HSD17B12)
SBQ: 101037623(HSD17B12)
MMU: 56348(Hsd17b12)
RNO: 84013(Hsd17b12)
CGE: 100751291(Hsd17b12)
NGI: 103746669(Hsd17b12)
HGL: 101706276 101717552(Hsd17b12)
CCAN: 109700741(Hsd17b12)
OCU: 100346603(HSD17B12) 103347152
TUP: 102495234(HSD17B12)
CFA: 475939(HSD17B12)
AML: 100484147(HSD17B12)
UMR: 103672348(HSD17B12)
ORO: 101367938(HSD17B12)
FCA: 101082595(HSD17B12)
PTG: 102963001(HSD17B12)
AJU: 106978054(HSD17B12)
BTA: 508455 789567(HSD17B12)
BOM: 102274407(HSD17B12) 102278627
BIU: 109569664(HSD17B12) 109572870
CHX: 102169696 102186887(HSD17B12)
OAS: 101110086(HSD17B12) 101112590
SSC: 100312972(HSD17B12)
CFR: 102505228 102515430(HSD17B12)
CDK: 105095461 105106832(HSD17B12)
BACU: 102998439(HSD17B12)
LVE: 103068441(HSD17B12)
OOR: 101273198 101279942(HSD17B12)
ECB: 100050075(HSD17B12) 100070719
EPZ: 103556323 103556451(HSD17B12) 103566841
EAI: 106843965(HSD17B12) 106848436
MYB: 102263289 102263627(HSD17B12)
MYD: 102758451 102766960(HSD17B12)
HAI: 109391968(HSD17B12)
RSS: 109441958 109455108(HSD17B12) 109459904
PALE: 102889386(HSD17B12)
LAV: 100656306(HSD17B12) 111749606
MDO: 100013277(HSD17B12)
SHR: 100917982(HSD17B12) 100923950
OAA: 100079057(HSD17B12)
GGA: 769787(HSD17B12)
MGP: 104911119(HSD17B12)
CJO: 107314810(HSD17B12)
APLA: 101803586(HSD17B12)
ACYG: 106044159(HSD17B12)
TGU: 100223843(HSD17B12)
GFR: 102039695(HSD17B12)
FAB: 101807632(HSD17B12)
PHI: 102106801(HSD17B12)
PMAJ: 107206004(HSD17B12)
CCAE: 111930136(HSD17B12)
CCW: 104688088(HSD17B12)
FPG: 101917180(HSD17B12)
FCH: 102056639(HSD17B12)
CLV: 102085015(HSD17B12)
EGZ: 104134096(HSD17B12)
AAM: 106498375(HSD17B12)
ASN: 102368497 102381002(HSD17B12)
AMJ: 102559362(HSD17B12)
PSS: 102445815(HSD17B12) 102455451 112544543
CMY: 102938030(HSD17B12) 102939820
CPIC: 101950937(HSD17B12)
PVT: 110081502(HSD17B12)
PBI: 103049647(HSD17B12)
GJA: 107119118(HSD17B12) 107120158
XLA: 108711776 379747(hsd17b12.S) 444506(LOC100497556.S) 495218(hsd17b12.L)
XTR: 100497556 549988(hsd17b12)
NPR: 108785839(HSD17B12) 108794729 108800692
DRE: 322626(hsd17b12b) 327417(hsd17b12a)
IPU: 100528251(dh12b) 108259770 108275383(hsd17b12)
AMEX: 103024613 103027081(hsd17b12) 103033448
TRU: 101067779(hsd17b12) 101069843 101072347
LCO: 104922399(hsd17b12) 104925842 104937328
MZE: 101464359 101469758 101474165(hsd17b12)
XMA: 102221080 102222061 102227570(hsd17b12)
KMR: 108234813 108245742(hsd17b12) 108248270
CSEM: 103378812 103379805(hsd17b12) 103395421
SDU: 111223976 111229620(hsd17b12) 111234380
MALB: 109959449 109965090 109973524(hsd17b12)
ELS: 105006117(hsd17b12) 105023923 105025310
SFM: 108918746 108934676 108942280(hsd17b12)
LCM: 102348665 102362094(HSD17B12)
CMK: 103174968(hsd17b12)
CIN: 445663(17-beta-HSD)
SPU: 593779
APLC: 110981629
DME: Dmel_CG1444(spidey)
DSI: Dsimw501_GD16868(Dsim_GD16868)
MDE: 101898425
AAG: 5580011
AME: 725258
AEC: 105152599
ACEP: 105617361
PBAR: 105433741
HST: 105182204
DQU: 106748186
CFO: 105251419
LHU: 105668502
PGC: 109859341
NVI: 100121752
MDL: 103569315
TCA: 660392
DPA: 109538015
NVL: 108559965
BMOR: 101744618
PMAC: 106714614
PRAP: 110993240
PXY: 105386843
ZNE: 110833461
FCD: 110850806
TUT: 107360802
CEL: CELE_C06B3.4(stdh-1) CELE_C06B3.5(stdh-3) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2) CELE_F25G6.5(stdh-4)
CBR: CBG11441 CBG19695(Cbr-let-767)
BMY: Bm1_45995
TSP: Tsp_02573
CRG: 105341564
MYI: 110454786
OBI: 106880401
LAK: 106169616
ATH: AT1G24470(KCR2) AT1G67730(KCR1)
LJA: Lj0g3v0295429.1(Lj0g3v0295429.1) Lj4g3v2717040.1(Lj4g3v2717040.1) Lj6g3v0585170.1(Lj6g3v0585170.1)
CANN: 107860712
NTO: 104087941
DOSA: Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299200-00(Os06g0299200) Os06t0299300-01(Os06g0299300) Os06t0300000-01(Os06g0300000)
ATS: 109733083(LOC109733083) 109733956(LOC109733956) 109733958(LOC109733958) 109736758(LOC109736758) 109743960(LOC109743960) 109744922(LOC109744922) 109745871(LOC109745871) 109746082(LOC109746082) 109746886(LOC109746886) 109747761(LOC109747761) 109755743(LOC109755743) 109756557(LOC109756557) 109765204(LOC109765204) 109765210(LOC109765210) 109766544(LOC109766544) 109766795(LOC109766795) 109768745(LOC109768745) 109771085(LOC109771085) 109772730(LOC109772730) 109773274(LOC109773274) 109773689(LOC109773689) 109779269(LOC109779269) 109781113(LOC109781113) 109781925(LOC109781925) 109782273(LOC109782273)
PPP: 112290473
APRO: F751_1671
SCE: YBR159W(IFA38)
ERC: Ecym_2565
NCS: NCAS_0B02360(NCAS0B02360)
NDI: NDAI_0C05330(NDAI0C05330)
TPF: TPHA_0L01460(TPHA0L01460)
TBL: TBLA_0H03430(TBLA0H03430)
TDL: TDEL_0B01260(TDEL0B01260)
KAF: KAFR_0E03020(KAFR0E03020)
PIC: PICST_79198(YBO9)
CAL: CAALFM_CR06070WA(CaO19.3859)
CAUR: QG37_06149
SLB: AWJ20_1871(IFA38)
NCR: NCU04462
NTE: NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
MGR: MGG_05096
MBE: MBM_06633
ANI: AN5861.2
ANG: ANI_1_488024(An02g03570)
CIM: CIMG_08188 CIMG_11390(CIMG04755)
PTE: PTT_14300
CNE: CNI00690
CNB: CNBH0660
ABP: AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: AGABI2DRAFT192460(AGABI2DRAFT_192460)
MGL: MGL_1839
DFA: DFA_11026
EHI: EHI_165070(127.t00009)
PYO: PY17X_0523800(PY05567)
PCB: PCHAS_052260(PC000268.05.0)
SPAR: SPRG_04210
TCR: 506219.40
BCEN: DM39_5665
BMK: DM80_3022
FLN: FLA_0019
 » show all
Taxonomy
Reference
1  [PMID:11792704]
  Authors
Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA
  Title
A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase.
  Journal
J Biol Chem 277:11481-8 (2002)
DOI:10.1074/jbc.M111441200
  Sequence
[sce:YBR159W]
Reference
2  [PMID:12087109]
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
DOI:10.1074/jbc.M205620200
  Sequence
[sce:YBR159W]
Reference
3  [PMID:19439572]
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant Physiol 150:1174-91 (2009)
DOI:10.1104/pp.109.137497
  Sequence
[ath:AT1G67730]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.330
IUBMB Enzyme Nomenclature: 1.1.1.330
ExPASy - ENZYME nomenclature database: 1.1.1.330
BRENDA, the Enzyme Database: 1.1.1.330

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