KEGG   ENZYME: 1.1.1.331Help
Entry
EC 1.1.1.331                Enzyme                                 

Name
secoisolariciresinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-secoisolariciresinol:NAD+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ [RN:R10129]
Reaction(KEGG)
Substrate
(-)-secoisolariciresinol [CPD:C18167];
NAD+ [CPD:C00003]
Product
(-)-matairesinol [CPD:C10682];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.
History
EC 1.1.1.331 created 2012
Orthology
K19650  secoisolariciresinol dehydrogenase
Reference
1  [PMID:11278426]
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J Biol Chem 276:12614-23 (2001)
DOI:10.1074/jbc.M008622200
  Sequence
Reference
2  [PMID:15653677]
  Authors
Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C
  Title
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.
  Journal
J Biol Chem 280:12917-26 (2005)
DOI:10.1074/jbc.M413266200
  Sequence
Reference
3  [PMID:16493463]
  Authors
Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.
  Journal
Org Biomol Chem 4:808-16 (2006)
DOI:10.1039/b516563f
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.331
IUBMB Enzyme Nomenclature: 1.1.1.331
ExPASy - ENZYME nomenclature database: 1.1.1.331
BRENDA, the Enzyme Database: 1.1.1.331

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