KEGG   ENZYME: 1.1.1.337Help
Entry
EC 1.1.1.337                Enzyme                                 

Name
L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]
Reaction(KEGG)
Substrate
(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]
Product
2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
EC 1.1.1.337 created 2012
Pathway
ec00680  Methane metabolism
Orthology
K05884  L-2-hydroxycarboxylate dehydrogenase (NAD+)
Genes
CUH: BJN34_35390
BHZ: ACR54_00590(allD)
BYL: A4V09_10375
SLE: sle_01170(sle_01170)
FRP: AX769_07390
SAAL: L336_0788(mdh)
MIB: UY43_C0001G0636
MJA: MJ_1425
MFE: Mefer_1396
MVU: Metvu_0738
MMP: MMP1133(comC)
MMD: GYY_06515
MAE: Maeo_1015
MVO: Mvol_0905
MTH: MTH_1205
MMG: MTBMA_c15830(comC)
METC: MTCT_1098
MWO: MWSIV6_1598(comC)
METE: tca_01162(yjmC)
MST: Msp_0279(comC)
MSI: Msm_1040
MRU: mru_1980(comC)
MEB: Abm4_1552(comC)
MMIL: sm9_2052(comC)
MEYE: TL18_09445
MOL: YLM1_1417
METH: MBMB1_1726(comC)
MFC: BRM9_0342(comC)
MFI: DSM1535_0956(comC)
MCUB: MCBB_2038(comC)
MFV: Mfer_0389
MKA: MK0392(comC)
 » show all
Taxonomy
Reference
1  [PMID:10850983]
  Authors
Graupner M, Xu H, White RH.
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000
  Sequence
[mja:MJ_1425]
Reference
2  [PMID:11451450]
  Authors
Graupner M, White RH.
  Title
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.
  Journal
Biochim Biophys Acta 1548:169-73 (2001)
DOI:10.1016/S0167-4838(01)00220-5
  Sequence
[mja:MJ_1425]
Reference
3  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
Reference
4  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM.
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.337
IUBMB Enzyme Nomenclature: 1.1.1.337
ExPASy - ENZYME nomenclature database: 1.1.1.337
BRENDA, the Enzyme Database: 1.1.1.337
CAS: 81210-65-3

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