KEGG   ENZYME: 1.1.1.338Help
Entry
EC 1.1.1.338                Enzyme                                 

Name
(2R)-3-sulfolactate dehydrogenase (NADP+);
(R)-sulfolactate:NADP+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R)-3-sulfolactate:NADP+ oxidoreductase
Reaction(IUBMB)
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+ [RN:R07137]
Reaction(KEGG)
Substrate
(2R)-3-sulfolactate [CPD:C11537];
NADP+ [CPD:C00006]
Product
3-sulfopyruvate [CPD:C05528];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
History
EC 1.1.1.338 created 2012
Pathway
ec00270  Cysteine and methionine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K16844  (2R)-3-sulfolactate dehydrogenase (NADP+)
Genes
SSAL: SPISAL_05330
APRS: BI364_08720
GAI: IMCC3135_02485(dpkA)
CSA: Csal_1771
HBE: BEI_0839(comC)
SVA: SVA_1861
TSN: W908_08240
RPJ: N234_02640
REU: Reut_B3531
CUH: BJN34_26765
CGD: CR3_0184(comC)
BFN: OI25_4405
BPA: BPP4084
BPAR: BN117_4156
BBR: BB4555
BPT: Bpet0408
BHO: D560_1789
BHM: D558_1780
BHZ: ACR54_04291(comC)
AXX: ERS451415_00470(allD_1)
AMIM: MIM_c39390
VEI: Veis_0890
HAR: HEAR3341
RGE: RGE_25200
BPRC: D521_1333
DVM: DvMF_1995
MLO: mll5197
SME: SMa1459
SMER: DU99_22025
SMD: Smed_5101
SFD: USDA257_c26040(yjmC)
ATU: Atu0164
ARA: Arad_4516
ATF: Ach5_01490(comC)
AGR: AGROH133_03129(mdh)
RIR: BN877_I0162(comC)
OCA: OCAR_7551
VGO: GJW-30_1_00128(comC_1)
AZC: AZC_1795
MNO: Mnod_3707
RVA: Rvan_2276
FIL: BN1229_v1_1880(comC)
FIY: BN1229_v1_1883(comC)
HDI: HDIA_2769(comC)
SIL: SPO3187(comC)
JAN: Jann_2141
RDE: RD1_2049
DSH: Dshi_2039
PSF: PSE_2587
PGD: Gal_03878
OTM: OSB_22100(comC)
MALG: MALG_01235
RSU: NHU_04237
RMM: ROSMUCSMR3_03370(comC)
AHT: ANTHELSMS3_02624(comC)
RCE: RC1_0266
TXI: TH3_01035
MRB: Mrub_2460
 » show all
Taxonomy
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
[csa:Csal_1771]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.338
IUBMB Enzyme Nomenclature: 1.1.1.338
ExPASy - ENZYME nomenclature database: 1.1.1.338
BRENDA, the Enzyme Database: 1.1.1.338
CAS: 81210-65-3

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