KEGG   ENZYME: 1.1.1.34Help
Entry
EC 1.1.1.34                 Enzyme                                 

Name
hydroxymethylglutaryl-CoA reductase (NADPH);
hydroxymethylglutaryl coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate);
3-hydroxy-3-methylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase;
hydroxymethylglutaryl CoA reductase (NADPH);
S-3-hydroxy-3-methylglutaryl-CoA reductase;
NADPH-hydroxymethylglutaryl-CoA reductase;
HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating-CoA);
3-hydroxy-3-methylglutaryl CoA reductase (NADPH);
hydroxymethylglutaryl-CoA reductase (NADPH2)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-mevalonate:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ [RN:R02082]
Reaction(KEGG)
Substrate
(R)-mevalonate [CPD:C00418];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
(S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is inactivated by EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase}.
History
EC 1.1.1.34 created 1961
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00021  hydroxymethylglutaryl-CoA reductase (NADPH)
Genes
HSA: 3156(HMGCR)
PTR: 471516(HMGCR)
PPS: 100990336(HMGCR)
GGO: 101128349 101136625(HMGCR)
PON: 100173499(HMGCR)
NLE: 100597442(HMGCR)
MCC: 705479(HMGCR)
MCF: 101926249(HMGCR)
CSAB: 103223243(HMGCR)
RRO: 104653755(HMGCR)
RBB: 108513080(HMGCR)
CJC: 100403990(HMGCR)
SBQ: 101033204(HMGCR)
MMU: 15357(Hmgcr)
RNO: 25675(Hmgcr)
CGE: 100756363(Hmgcr)
NGI: 103731354(Hmgcr)
HGL: 101717005(Hmgcr)
CCAN: 109700493(Hmgcr)
OCU: 100357791(HMGCR)
TUP: 102480274(HMGCR)
CFA: 479182(HMGCR)
AML: 100464316(HMGCR)
UMR: 103663564(HMGCR)
ORO: 101368294(HMGCR)
FCA: 101098922(HMGCR)
PTG: 102963640(HMGCR)
AJU: 106974837(HMGCR)
BTA: 407159(HMGCR)
BOM: 102270355(HMGCR)
BIU: 109564640(HMGCR)
PHD: 102343301(HMGCR)
CHX: 102169762(HMGCR)
OAS: 101108919(HMGCR)
SSC: 100144446(HMGCR)
CFR: 102507285(HMGCR)
CDK: 105084800(HMGCR)
LVE: 103081068(HMGCR)
OOR: 101275846(HMGCR)
ECB: 100065577(HMGCR)
EPZ: 103555449(HMGCR)
EAI: 106824005(HMGCR)
MYB: 102262745(HMGCR)
MYD: 102767367(HMGCR)
HAI: 109381933(HMGCR)
RSS: 109440457 109445619(HMGCR)
PALE: 102890076(HMGCR)
LAV: 100661990(HMGCR)
TMU: 101360660
MDO: 100014439(HMGCR)
SHR: 100922433(HMGCR)
OAA: 100086613(HMGCR)
GGA: 395145(HMGCR)
MGP: 104915886(HMGCR)
CJO: 107306044(HMGCR)
APLA: 101805369(HMGCR)
ACYG: 106042919(HMGCR)
TGU: 100228972(HMGCR)
GFR: 102039836(HMGCR)
FAB: 101812070(HMGCR)
PHI: 102101959(HMGCR)
PMAJ: 107215886(HMGCR)
CCW: 104685133(HMGCR)
FPG: 101915600(HMGCR)
FCH: 102052105(HMGCR)
CLV: 102088196(HMGCR)
EGZ: 104124861(HMGCR)
ASN: 102386377(HMGCR)
AMJ: 102571444(HMGCR)
PSS: 102459565(HMGCR)
CMY: 102947767(HMGCR)
CPIC: 101931267(HMGCR)
ACS: 100555648(hmgcr)
PVT: 110084573
PBI: 103059006(HMGCR)
GJA: 107118163(HMGCR)
XLA: 108707262(hmgcr.S) 397750(hmgcr.L)
XTR: 100380121(hmgcr)
NPR: 108796370(HMGCR)
DRE: 541479(hmgcrb) 559054(hmgcra)
IPU: 108255489(hmgcr) 108278928(HMGCR)
TRU: 101066905(hmgcr) 101078757
LCO: 104926606 104937871(hmgcr)
XMA: 102229336 102237239(hmgcr)
PRET: 103470679(hmgcr) 103473284
CSEM: 103389902 103397369(hmgcr)
LCF: 108873800 108878542(hmgcr)
HCQ: 109510552(hmgcr) 109525561
BPEC: 110157405 110172435(hmgcr)
SASA: 100380797(hmdh) 106570829(hmgcr)
ELS: 105009321(hmgcr) 105015131
SFM: 108925108(hmgcr)
LCM: 102361998(HMGCR)
CMK: 103186373(hmgcr)
CIN: 100187175
SPU: 373355(HMGCR)
APLC: 110986789
SKO: 100369866
DME: Dmel_CG10367(Hmgcr)
DSI: Dsimw501_GD21034(Dsim_GD21034)
MDE: 101892909
AAG: 5571790
AME: 550724
BIM: 100746066
BTER: 100651787
AEC: 105152804
ACEP: 105625102
PBAR: 105429601
HST: 105189357
CFO: 105256970
LHU: 105667949
PGC: 109859982
NVI: 100117068
BMOR: 100101204(Hmg-r)
PMAC: 106715604
PRAP: 110997222
PXY: 105398578
DNX: 107170987
ZNE: 110835092
DPX: DAPPUDRAFT_346929(Hmgcr)
TUT: 107360294
CEL: CELE_F08F8.2(hmgr-1)
CBR: CBG15296
BMY: Bm1_54020
TSP: Tsp_10921
CRG: 105320820
MYI: 110454220
OBI: 106880618
LAK: 106162017
SHX: MS3_08471
EPA: 110243168
ADF: 107344111
HMG: 100215451
AQU: 100635846
ATH: AT1G76490(HMG1) AT2G17370(HMG2)
LJA: Lj0g3v0018799.1(Lj0g3v0018799.1) Lj0g3v0268939.1(Lj0g3v0268939.1) Lj2g3v1574250.1(Lj2g3v1574250.1) Lj2g3v1575430.1(Lj2g3v1575430.1) Lj2g3v2948500.1(Lj2g3v2948500.1)
BVG: 104904096
DOSA: Os02t0713900-01(Os02g0713900) Os08t0512700-01(Os08g0512700) Os09t0492700-01(Os09g0492700)
ATS: 109746630(LOC109746630) 109752372(LOC109752372) 109782286(LOC109782286)
ATR: 18439724
SCE: YLR450W(HMG2) YML075C(HMG1)
ERC: Ecym_1136
KMX: KLMA_40445(HMG1)
NCS: NCAS_0A06180(NCAS0A06180)
NDI: NDAI_0D03170(NDAI0D03170)
TPF: TPHA_0B00420(TPHA0B00420) TPHA_0B01590(TPHA0B01590)
TBL: TBLA_0E04740(TBLA0E04740)
TDL: TDEL_0D00740(TDEL0D00740)
KAF: KAFR_0E04250(KAFR0E04250) KAFR_0I00290(KAFR0I00290)
PIC: PICST_72872(HMG1)
CAL: CAALFM_C103780CA(HMG1)
CAUR: QG37_02076
SLB: AWJ20_1837(HMG1)
NCR: NCU00712
NTE: NEUTE1DRAFT89746(NEUTE1DRAFT_89746)
MGR: MGG_08975
SSCK: SPSK_01389
FPU: FPSE_03466(HMR1)
NHE: NECHADRAFT_105420(NhHMR1)
MAW: MAC_02791
MAJ: MAA_05256
CMT: CCM_04994
MBE: MBM_03374
ANG: ANI_1_1022064(An07g08280)
ABE: ARB_00275
TVE: TRV_00650
PTE: PTT_07524
ZTR: MYCGRDRAFT_64888(HMG1)
SPO: SPCC162.09c(hmg1)
CNE: CNF04830
CNB: CNBF0070
ABP: AGABI1DRAFT64187(AGABI1DRAFT_64187)
ABV: AGABI2DRAFT208992(AGABI2DRAFT_208992)
MGL: MGL_3624
DDI: DDB_G0269142(hmgA) DDB_G0276615(hmgB)
DFA: DFA_02965(hmgB) DFA_07220
SPAR: SPRG_01272
LMA: LMJF_30_3190(HMGR)
LIF: LINJ_30_3230(HMGR)
PAY: PAU_02226
VCH: VCA0723
VCS: MS6_A0769
VCE: Vch1786_II0408(hmgA)
VCI: O3Y_16913
VCR: VC395_A0589(hmgA)
VCM: VCM66_A0681(hmgA)
VVU: VV2_0117
VVY: VVA0625
VPA: VPA0968
VAG: N646_4347
VSP: VS_II0457
VAN: VAA_01552
VAU: VANGNB10_cII0695(hmgA)
VTA: B0124(hmgA)
VFI: VF_A0841
PSIL: PMA3_24025
PAT: Patl_0427
GNI: GNIT_1294(hmg1)
SAGA: M5M_16240
CBD: CBUD_0151 CBUD_0622(hmgA)
CBG: CbuG_0298 CbuG_1393(hmgA)
CBC: CbuK_0218 CbuK_1440(hmgA)
CEY: CleRT_04160(hmgA)
TCX: Tcr_1717
DNO: DNO_0797
SVA: SVA_3750
CVI: CV_1806
BOK: DM82_1348
BOC: BG90_3346
LAA: WSI_04450
LSO: CKC_03800
LAR: lam_722(hMG1)
SAY: TPY_0167
MUL: MUL_3522
MMI: MMAR_3214
CKP: ckrop_0031(mvaA)
CVA: CVAR_1983(mvaA)
CTER: A606_07960
COA: DR71_1489
NFA: NFA_22110
SDV: BN159_7954(hmgA3)
STRE: GZL_00237
SFK: KY5_0603c
IDO: I598_0505
BSD: BLASA_0285(hmgA)
GBA: J421_4295
SRU: SRU_2422
SRM: SRM_02640(hmgA)
SGN: SGRA_2249
FAE: FAES_4555(hmgA)
HSW: Hsw_4017
FLM: MY04_1691
MJA: MJ_0705
MMP: MMP0087(hmgA)
MMD: GYY_00445
MAE: Maeo_0718
MVO: Mvol_1440
MTH: MTH_562
MMG: MTBMA_c09500(hmgA)
METC: MTCT_0489
MWO: MWSIV6_0926(hmgA)
METE: tca_00533
MST: Msp_0584(hmgA)
MSI: Msm_0227
MRU: mru_1092(hmgA)
MEB: Abm4_0894(hmgA)
MMIL: sm9_0824(hmgA)
MEYE: TL18_06175
MOL: YLM1_0775
METH: MBMB1_1357(hmgA)
MFC: BRM9_0582(hmgA)
MFI: DSM1535_0563(hmgA)
MCUB: MCBB_1594(hmgA)
MFV: Mfer_0012
MKA: MK0355(hmg1)
MEAR: Mpt1_c04890(hmgA)
MARC: AR505_0768
PHO: PH1805(PH1805)
PAB: PAB2106
PFU: PF1848
PFI: PFC_09350
PYN: PNA2_0404
PYS: Py04_1729
TKO: TK0914
TON: TON_0399
TGA: TGAM_1146(hmgA)
TSI: TSIB_0612
THE: GQS_03225
THA: TAM4_2137
THM: CL1_0345
TLT: OCC_04595
THS: TES1_0465
TNU: BD01_0308
TEU: TEU_07265
THH: CDI07_02645(hmgA)
PPAC: PAP_03560
MAC: MA_3073(hmgA)
MBAR: MSBR2_1683
MBAK: MSBR3_1674
MMA: MM_0335
MMAC: MSMAC_0968
METM: MSMTP_2268
MTHE: MSTHC_0758
MTHR: MSTHT_2527
MHOR: MSHOH_1143
MBU: Mbur_1098
MMET: MCMEM_1587
MMH: Mmah_0566
MPY: Mpsy_2819
MHU: Mhun_3004
MLA: Mlab_1655
MBG: BN140_2503(hmgA)
MEMA: MMAB1_3364
MPI: Mpet_0546
MBN: Mboo_0137
MPL: Mpal_2647
MPD: MCP_3002(hmgA-2)
MEZ: Mtc_0456(hmgA-2)
RCI: RCIX1027(hmgA)
HAL: VNG_1875G(mvaA)
HSL: OE_3637R(hmgA)
HHB: Hhub_3224(hmgA)
HSU: HLASF_1924(hmgA)
HSF: HLASA_1910(hmgA)
HMA: rrnAC3412(mvaA)
HHI: HAH_0640(hmg)
NPH: NP_0368A(hmgA2) NP_2422A(hmgA1)
NMO: Nmlp_2407(hmgA)
HUT: Huta_0276
HTI: HTIA_0459
HMU: Hmuk_1499
HWA: HQ_3215A(hmgA)
HWC: Hqrw_3777(hmgA)
HVO: HVO_2583(hmgA)
HME: HFX_2609(hmgR)
HAQ: DU484_05000(hmgA)
HLA: Hlac_2019
SRUB: C2R22_15940(hmgA)
HTU: Htur_0537
NMG: Nmag_2929(hmgA)
NAT: NJ7G_4215
SALI: L593_03550
APE: APE_1869(hmgA)
ACJ: ACAM_1174(hmgA)
SMR: Smar_1337
IHO: Igni_0476
IIS: EYM_00605
HBU: Hbut_1531
STO: STK_13520(hmgA)
SSO: SSO0531
SOL: Ssol_1610
SSOA: SULA_1637
SSOL: SULB_1638
SSOF: SULC_1636
SAI: Saci_1359
SID: M164_1581
SII: LD85_1792
SIH: SiH_1551
SIR: SiRe_1459
SIC: SiL_1461
MSE: Msed_1649
MCN: Mcup_0580
MHK: DFR87_10465(hmgA)
AHO: Ahos_1305
PAI: PAE2182
PIS: Pisl_0814
PCL: Pcal_1085
PAS: Pars_0796
PYR: P186_0419
POG: Pogu_1536
TNE: Tneu_1359
CMA: Cmaq_0412
TUZ: TUZN_1176
TTN: TTX_0171(mvaA)
VDI: Vdis_1666
VMO: VMUT_2295
ASC: ASAC_1038
ACIA: SE86_06315
MARH: Mia14_0330
 » show all
Taxonomy
Reference
1  [PMID:13805544]
  Authors
BUCHER NL, OVERATH P, LYNEN F
  Title
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver.
  Journal
Biochim Biophys Acta 40:491-501 (1960)
Reference
2  [PMID:13818862]
  Authors
DURR IF, RUDNEY H.
  Title
The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid.
  Journal
J Biol Chem 235:2572-8 (1960)
Reference
3  [PMID:4985697]
  Authors
Kawachi T, Rudney H.
  Title
Solubilization and purification of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver.
  Journal
Biochemistry 9:1700-5 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.34
IUBMB Enzyme Nomenclature: 1.1.1.34
ExPASy - ENZYME nomenclature database: 1.1.1.34
BRENDA, the Enzyme Database: 1.1.1.34
CAS: 9028-35-7

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