KEGG   ENZYME: 1.1.1.41Help
Entry
EC 1.1.1.41                 Enzyme                                 

Name
isocitrate dehydrogenase (NAD+);
isocitric dehydrogenase;
beta-ketoglutaric-isocitric carboxylase;
isocitric acid dehydrogenase;
NAD dependent isocitrate dehydrogenase;
NAD isocitrate dehydrogenase;
NAD-linked isocitrate dehydrogenase;
NAD-specific isocitrate dehydrogenase;
NAD isocitric dehydrogenase;
isocitrate dehydrogenase (NAD);
IDH (ambiguous);
nicotinamide adenine dinucleotide isocitrate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isocitrate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709]
Reaction(KEGG)
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9].
History
EC 1.1.1.41 created 1961, modified 2005
Pathway
ec00020  Citrate cycle (TCA cycle)
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K00030  isocitrate dehydrogenase (NAD+)
Genes
HSA: 3419(IDH3A) 3420(IDH3B) 3421(IDH3G)
PTR: 453565(IDH3A) 458048(IDH3B) 741179(IDH3G)
PPS: 100968720(IDH3B) 100972968(IDH3G) 100987648(IDH3A)
GGO: 101126919(IDH3G) 101135027(IDH3A) 101141517(IDH3B)
PON: 100172089(IDH3A) 100172344(IDH3B) 100436005(IDH3G)
NLE: 100590336(IDH3B) 100593540(IDH3G) 100606177(IDH3A)
MCC: 677715(IDH3A) 698558(IDH3G) 716726(IDH3B)
MCF: 101865050(IDH3A) 102124727(IDH3G) 102129545(IDH3B)
CSAB: 103215621(IDH3B) 103232801(IDH3G) 103245258(IDH3A)
RRO: 104661175(IDH3G) 104674376(IDH3A) 104674627(IDH3B)
RBB: 108514547 108524292(IDH3A) 108529987(IDH3B) 108535078(IDH3G)
CJC: 100403538(IDH3B) 100405727(IDH3G) 100413152(IDH3A)
SBQ: 101032511(IDH3G) 101041482 101043727 101050203(IDH3A) 101051785(IDH3B)
MMU: 15929(Idh3g) 170718(Idh3b) 243996(4933405O20Rik) 67834(Idh3a)
RNO: 100125384 103690168 114096(Idh3a) 25179(Idh3g) 94173(Idh3B)
CGE: 100751753(Idh3g) 100754480(Idh3a) 100771661(Idh3b) 100772968
NGI: 103726021(Idh3a) 103731201(Idh3g) 103751138(Idh3b)
HGL: 101706503(Idh3a) 101709094(Idh3b) 101721638(Idh3g)
CCAN: 109674406 109682388(Idh3a) 109692900(Idh3b) 109698474(Idh3g)
OCU: 100328743(IDH3G) 100338100(IDH3A) 100342113(IDH3B) 103351073
TUP: 102475641(IDH3G) 102479509(IDH3A) 102493633(IDH3B) 102494733
CFA: 477177(IDH3B) 479066(IDH3A) 481081(IDH3G)
AML: 100466084(IDH3B) 100473236 100482520(IDH3A) 100483295(IDH3G)
UMR: 103659417 103660316(IDH3A) 103674513(IDH3B) 103679698(IDH3G)
ORO: 101365002(IDH3A) 101378494(IDH3G) 101380358 101380671(IDH3B)
FCA: 101085721(IDH3A) 101086177 101099035(IDH3B) 102902308(IDH3G)
PTG: 102954160(IDH3G) 102955736(IDH3B) 102968859(IDH3A)
AJU: 106978422 106980169(IDH3B) 106988469(IDH3A) 106989688(IDH3G)
BTA: 282446(IDH3A) 613338(IDH3B) 614145(IDH3G)
BOM: 102269910(IDH3B) 102273099(IDH3G) 102281295(IDH3A)
BIU: 109555187(IDH3G) 109567214(IDH3B) 109575516(IDH3A)
PHD: 102318399(IDH3A) 102322009(IDH3G) 102324803(IDH3B)
CHX: 102172823(IDH3B) 102181480(IDH3G) 102181902(IDH3A)
OAS: 101104080(IDH3B) 101110910(IDH3G) 101120868(IDH3A)
SSC: 100157242(IDH3A) 100525850(IDH3G) 733641(IDH3B)
CFR: 102504528(IDH3A) 102504939(IDH3B) 102513449(IDH3G) 106731107
CDK: 105092226(IDH3A) 105096042(IDH3B) 105098707(IDH3G)
BACU: 102998515(IDH3B) 103016817(IDH3G) 103018652(IDH3A)
LVE: 103072517(IDH3B) 103087344(IDH3A) 103091109(IDH3G)
OOR: 101273087(IDH3B) 101277332(IDH3G) 101278784(IDH3A)
ECB: 100052969(IDH3B) 100057896(IDH3G) 100060114(IDH3A) 102148971
EAI: 106823126(IDH3B) 106825620(IDH3G) 106831328 106840824(IDH3A)
MYB: 102247279(IDH3A) 102248160(IDH3B) 102258465 102262688(IDH3G)
MYD: 102759311(IDH3A) 102760750(IDH3G) 102762142(IDH3B) 102771723
HAI: 109381453(IDH3A) 109384445(IDH3B) 109387447 109394340(IDH3G)
PALE: 102879783(IDH3B) 102885938(IDH3G) 102889641 102898135(IDH3A)
LAV: 100654370(IDH3G) 100660691(IDH3A) 100675574(IDH3B) 111751222
MDO: 100012825(IDH3A) 100017654(IDH3B) 100027983(IDH3G)
SHR: 100926332(IDH3A) 100926870(IDH3G) 100927370(IDH3B)
OAA: 100080286(IDH3G) 100082669(IDH3A)
GGA: 415362(IDH3A) 426573(IDH3B)
MGP: 100538992(IDH3B) 100549122(IDH3A)
CJO: 107306828(IDH3B) 107307385 107318544(IDH3A)
APLA: 101795551(IDH3A)
ACYG: 106033768(IDH3A) 106043186(IDH3B)
TGU: 100190682(IDH3A) 100224627(IDH3B)
GFR: 102031374(IDH3A) 102037020(IDH3B) 102037586
FAB: 101812942(IDH3B) 101821410(IDH3A)
PHI: 102101435(IDH3G) 102102008(IDH3A) 102102923(IDH3B)
PMAJ: 107199392 107199464(IDH3G) 107209223(IDH3A)
CCW: 104697486(IDH3A)
FPG: 101911234(IDH3A) 101917018 101924179(IDH3B)
FCH: 102046523(IDH3B) 102049683(IDH3G) 102059274(IDH3A)
CLV: 102084068(IDH3A) 102089326(IDH3B)
EGZ: 104130745(IDH3A) 104134110
AAM: 106485317(IDH3B) 106496514(IDH3A)
ASN: 102376426(IDH3B) 102384371(IDH3G) 102387605(IDH3A)
AMJ: 102572722(IDH3G) 102572950(IDH3A) 106737711(IDH3B)
PSS: 102447300(IDH3B) 102452545(IDH3A)
CMY: 102940870 102946721(IDH3A)
CPIC: 101937934(IDH3B) 101944131(IDH3G) 101949218(IDH3A)
ACS: 100558969(idh3b) 100566326(idh3a) 100567899(idh3g)
PVT: 110074541(IDH3A) 110078605(IDH3G) 110079816(IDH3B)
PBI: 103057793(IDH3G) 103058661(IDH3A) 103060348
GJA: 107105573(IDH3G) 107110629(IDH3A) 107117632(IDH3B)
XLA: 108711283(idh3a.L) 443821(idh3b.S) 444419(idh3a.S) 444551(idh3g.S)
XTR: 100144949(idh3b) 394979(idh3a) 594985(idh3g)
NPR: 108784060(IDH3A) 108801780(IDH3G) 108802712(IDH3B)
DRE: 393926(idh3a) 415247(idh3b) 550579(idh3g)
IPU: 100528472(idh3a) 108275983(IDH3G) 108276129 108279145(idh3b)
AMEX: 103022909(idh3b) 103033368 103040116(idh3a) 103045952
TRU: 101066481(idh3g) 101068530(idh3a) 101078713(idh3b)
LCO: 104917860(idh3a) 104928357 104928936(idh3b) 104932746(idh3g)
NCC: 104946225(idh3g) 104951613 104951620 104953439(idh3a) 104964856(idh3b)
OLA: 101156895 101164134(idh3a) 101166544(idh3b) 101169534(idh3g)
XMA: 102224210(idh3a) 102227101(idh3b) 102236069(idh3g)
PRET: 103460078(idh3a) 103465018(idh3b) 103466577 103467325(idh3g)
NFU: 107381511(idh3a) 107385459(idh3b) 107390856(idh3g)
CSEM: 103378915 103379971(idh3a) 103384582(idh3g) 103385211 103386635(idh3b)
BPEC: 110164549(idh3g) 110166714(idh3b) 110169069(idh3a)
LCM: 102349413(IDH3A) 102351121(IDH3G) 102357101(IDH3B) 102362883
CMK: 103173064(idh3b) 103188099(idh3a)
DME: Dmel_CG12233(l(1)G0156) Dmel_CG32026(CG32026) Dmel_CG3483(CG3483) Dmel_CG5028(CG5028) Dmel_CG6439(Idh3b)
DSI: Dsimw501_GD11857(Dsim_GD11857) Dsimw501_GD14133(Dsim_GD14133) Dsimw501_GD15579(Dsim_GD15579) Dsimw501_GD18486(Dsim_GD18486) Dsimw501_GD21232(Dsim_GD21232)
CEL: CELE_C30F12.7(idhg-2) CELE_C37E2.1(idhb-1) CELE_F35G12.2(idhg-1) CELE_F43G9.1(idha-1)
ATH: AT1G32480(IDH-IV) AT2G17130(IDH2) AT3G09810(IDH-VI) AT4G35260(IDH1) AT4G35650(IDH-III) AT5G03290(IDH-V)
LJA: Lj0g3v0312989.1(Lj0g3v0312989.1) Lj2g3v1646570.1(Lj2g3v1646570.1) Lj2g3v1646570.2(Lj2g3v1646570.2) Lj5g3v0659740.1(Lj5g3v0659740.1) Lj5g3v0659740.2(Lj5g3v0659740.2)
DOSA: Os01t0276100-01(Os01g0276100) Os02t0595500-01(Os02g0595500) Os04t0479200-01(Os04g0479200)
ATS: 109758292(LOC109758292) 109772564(LOC109772564) 109773327(LOC109773327) 109784280(LOC109784280)
APRO: F751_3437
SCE: YNL037C(IDH1) YOR136W(IDH2)
KMX: KLMA_20575(IDH2) KLMA_80139(IDH1)
NCS: NCAS_0B06290(NCAS0B06290) NCAS_0H02250(NCAS0H02250)
NDI: NDAI_0B03590(NDAI0B03590) NDAI_0C01410(NDAI0C01410)
TPF: TPHA_0D01560(TPHA0D01560) TPHA_0E01480(TPHA0E01480) TPHA_0J02770(TPHA0J02770)
TBL: TBLA_0B02240(TBLA0B02240) TBLA_0B06910(TBLA0B06910)
TDL: TDEL_0A03370(TDEL0A03370) TDEL_0C03840(TDEL0C03840)
KAF: KAFR_0B06370(KAFR0B06370) KAFR_0J01410(KAFR0J01410)
PIC: PICST_42313(IDH2) PICST_91057(IDH1)
CAUR: QG37_07052
SLB: AWJ20_1546(IDH1) AWJ20_2295(IDH2)
NCR: NCU00775(tca-6) NCU07697(tca-4)
NTE: NEUTE1DRAFT116362(NEUTE1DRAFT_116362) NEUTE1DRAFT118602(NEUTE1DRAFT_118602)
BFU: BCIN_01g07460(Bcidh1) BCIN_07g04280(Bcidh2)
ANG: ANI_1_798074(An08g05580) ANI_1_906164(An18g06760)
SPO: SPAC11G7.03(idh1) SPBC902.05c(idh2)
ABP: AGABI1DRAFT113316(AGABI1DRAFT_113316) AGABI1DRAFT113330(AGABI1DRAFT_113330)
ABV: AGABI2DRAFT135516(AGABI2DRAFT_135516) AGABI2DRAFT192040(AGABI2DRAFT_192040)
DDI: DDB_G0271344(idhA) DDB_G0293872(idhB)
DFA: DFA_05642(idhA) DFA_10000(idhB)
EFE: EFER_3668
KPNK: BN49_4521
XFA: XF_2596
XFT: PD_1973(icdA)
XCC: XCC0967(icd)
XCB: XC_3268
XCA: xcc-b100_3384(icd1)
XCP: XCR_1165
XCV: XCV1076
XAX: XACM_1027
XAC: XAC1046(icd)
XCI: XCAW_03534(leuB)
XOO: XOO1024(icd)
XOM: XOO0926(XOO0926)
XOP: PXO_02485
XOR: XOC_1121
XAL: XALC_0579
XPH: XppCFBP6546_06235(XppCFBP6546P_06235)
SML: Smlt0982
SMT: Smal_0828
SMZ: SMD_0856
PSUW: WQ53_02245
PSD: DSC_12115
LEZ: GLE_1654
LEM: LEN_3313(leuB)
DKO: I596_2711
PSIL: PMA3_09505
SON: SO_1538
SDN: Sden_2561
SFR: Sfri_2779
SAZ: Sama_2423
SBL: Sbal_1368
SLO: Shew_2760
SSE: Ssed_3318
SPL: Spea_2980
SHL: Shal_3069
SWD: Swoo_3466
SWP: swp_3606
SVO: SVI_1132
SPSW: Sps_02235
ILO: IL0861
CPS: CPS_3540
PHA: PSHAb0465
PAT: Patl_3197
PSM: PSM_B0541
PSEO: OM33_18470
PSPO: PSPO_b0908
PART: PARC_b0717
PSEN: PNC201_19395(icd2)
AMAL: I607_04505
AMAE: I876_04715
AMAO: I634_04890
AMAD: I636_04735
AMAI: I635_04710
AMAG: I533_04470
AMAC: MASE_04350
AAUS: EP12_04695
GNI: GNIT_2478
SALH: HMF8227_02174(idh3)
FBL: Fbal_2814
MVS: MVIS_3870(icd)
MCA: MCA3071
MAH: MEALZ_3026(icd)
AEH: Mlg_0664
GAI: IMCC3135_33170(icd_3)
CSA: Csal_1434
HAM: HALO1246
ABO: ABO_0296(icd)
ADI: B5T_00711(icd)
AXE: P40_03350
AHA: AHA_1152
ASA: ASA_3183
AVR: B565_3077
AMED: B224_4096
ASR: WL1483_4388(idh5)
ACAV: VI35_15655
OCE: GU3_06935
SALN: SALB1_0309
REH: H16_B1016(icd3)
CNC: CNE_2c09750(leuB)
CGD: CR3_3459
BXE: Bxe_C0665
BXB: DR64_7780
HAR: HEAR3270(icd1)
MMS: mma_3499(idh)
CFU: CFU_0031(citC)
LCH: Lcho_4250
TIN: Tint_2512
THI: THI_2911(idh2)
MXA: MXAN_6337
CCX: COCOR_06955(leuB2)
SCL: sce5773(icd1) sce6432(leuB2)
HOH: Hoch_0287
BBA: Bd1264(leuB)
BBAT: Bdt_1246(leuB)
BBW: BDW_04345
BBAC: EP01_16250
BEX: A11Q_1653
VGO: GJW-30_1_02260(icd_1)
MET: M446_0777
GOX: GOX1336
GOH: B932_1561
GDI: GDI1991
GDJ: Gdia_0214
GXY: GLX_27020
GXL: H845_645
KEU: S101446_03035(idh3)
APK: APA386B_2558(icd1)
ASZ: ASN_91(icd1)
THL: TEH_24000(icd)
CAC: CA_C0972(citC)
CAE: SMB_G0989(icd)
CAY: CEA_G0983(citC)
CBO: CBO0419
CBA: CLB_0452
CBH: CLC_0485
CBY: CLM_0498
CBL: CLK_3621
CBB: CLD_0324
CBI: CLJ_B0487
CBN: CbC4_1895
CBF: CLI_0504
CBM: CBF_0471
CPAS: Clopa_3427
CPAT: CLPA_c14680(leuB1)
CPAE: CPAST_c14680(leuB1)
CSQ: CSCA_3671
CLD: CLSPO_c04570(icd)
CACE: CACET_c05310(icd)
CTYK: CTK_C06630(citC)
AMT: Amet_1319
HSC: HVS_05270(icd2)
CCEL: CCDG5_1613
CPY: Cphy_3096
HSD: SD1D_0729
CPRO: CPRO_08860(icd)
CDF: CD630_08340(icd)
PDC: CDIF630_00953(icd)
PDF: CD630DERM_08340(icd)
CST: CLOST_1243(icd)
PTH: PTH_2517(LeuB)
DAU: Daud_1038
ELM: ELI_1525
AWO: Awo_c24380(icd)
TMR: Tmar_1163
CTHM: CFE_2578
BPRS: CK3_23360
CHY: CHY_1107
MTA: Moth_0993
ADG: Adeg_1102
TPZ: Tph_c09030(leuB1)
CSC: Csac_0751
ATE: Athe_0525
APR: Apre_1101
MED: MELS_0492
MHG: MHY_29150
AIN: Acin_1202(icd)
LPIL: LIP_1411
ACTI: UA75_18165
ACAD: UA74_17640
RXY: Rxyl_1297
ELE: Elen_2334
CBAC: JI75_08125
CYA: CYA_1467
CYB: CYB_1678
TEL: tlr0302
AMR: AM1_5753(icd)
GVI: gvip428(icd)
GLJ: GKIL_0806(icd)
DET: DET0450
DEH: cbdbA408
DEV: DhcVS_392
DMC: btf_415(icd)
DMD: dcmb_461(icd)
DMG: GY50_0375
DUC: UCH007_03820(icd)
HAU: Haur_1453
STI: Sthe_1662
TTR: Tter_0788
PSL: Psta_0983
PLM: Plim_0079
PLS: VT03_27220(icd)
PLH: VT85_11360(hicd)
TTF: THTE_1950
GES: VT84_27710(icd_2) VT84_27735(hicd) VT84_27740(icd_3)
IPA: Isop_1279
PBOR: BSF38_05134(hicd)
ACA: ACP_1462
ABAS: ACPOL_1167
SUS: Acid_7350
ABAC: LuPra_05591(icd_2)
EMI: Emin_0404
EPO: Epro_0346(icd)
LBA: Lebu_1446
GAU: GAU_2477(icd)
GBA: J421_3937
SRU: SRU_1677
SRM: SRM_01881(icd)
HSW: Hsw_4120
CTS: Ctha_2161
PMO: Pmob_1706
DTN: DTL3_1456(l(1)G0156)
CABY: Cabys_3783
NMV: NITMOv2_2967(IDH) NITMOv2_3291(icd)
LFC: LFE_0769
BANA: BARAN1_0872(IDH)
MARC: AR505_0531
ABI: Aboo_1463
MTP: Mthe_0549
MCJ: MCON_1315(aksF)
MHI: Mhar_1328
IAG: Igag_1773
KCR: Kcr_0970
 » show all
Taxonomy
Reference
1  [PMID:14063317]
  Authors
HATHAWAY JA, ATKINSON DE.
  Title
THE EFFECT OF ADENYLIC ACID ON YEAST NICOTINAMIDE ADENINE DINUCLEOTIDE ISOCITRATE DEHYDROGENASE, A POSSIBLE METABOLIC CONTROL MECHANISM.
  Journal
J Biol Chem 238:2875-81 (1963)
Reference
2  [PMID:14832224]
  Authors
KORNBERG A, PRICER WE Jr.
  Title
Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast.
  Journal
J Biol Chem 189:123-36 (1951)
Reference
3
  Authors
Plaut, G.W.E.
  Title
Isocitrate dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 105-126.
Reference
4  [PMID:13152105]
  Authors
PLAUT GW, SUNG SC.
  Title
Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.
  Journal
J Biol Chem 207:305-14 (1954)
Reference
5
  Authors
Ramakrishnan, C.V. and Martin, S.M.
  Title
Isocitric dehydrogenase in Aspergillus niger.
  Journal
Arch Biochem Biophys 55:403-407 (1955)
Reference
6  [PMID:13925783]
  Authors
VICKERY HB.
  Title
A suggested new nomenclature for the isomers of isocitric acid.
  Journal
J Biol Chem 237:1739-41 (1962)
Reference
7  [PMID:8593959]
  Authors
Camacho ML, Brown RA, Bonete MJ, Danson MJ, Hough DW.
  Title
Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence.
  Journal
FEMS Microbiol Lett 134:85-90 (1995)
DOI:10.1111/j.1574-6968.1995.tb07919.x
Reference
8  [PMID:10601238]
  Authors
Kim YO, Koh HJ, Kim SH, Jo SH, Huh JW, Jeong KS, Lee IJ, Song BJ, Huh TL.
  Title
Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform.
  Journal
J Biol Chem 274:36866-75 (1999)
DOI:10.1074/jbc.274.52.36866
  Sequence
[hsa:3420]
Reference
9  [PMID:12204383]
  Authors
Inoue H, Tamura T, Ehara N, Nishito A, Nakayama Y, Maekawa M, Imada K, Tanaka H, Inagaki K.
  Title
Biochemical and molecular characterization of the NAD(+)-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans.
  Journal
FEMS Microbiol Lett 214:127-32 (2002)
DOI:10.1111/j.1574-6968.2002.tb11335.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.41
IUBMB Enzyme Nomenclature: 1.1.1.41
ExPASy - ENZYME nomenclature database: 1.1.1.41
BRENDA, the Enzyme Database: 1.1.1.41
CAS: 9001-58-5

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