KEGG   ENZYME: 1.1.1.45Help
Entry
EC 1.1.1.45                 Enzyme                                 

Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K13247  L-gulonate 3-dehydrogenase
Genes
HSA: 51084(CRYL1)
PTR: 452458(CRYL1)
PPS: 100972837(CRYL1)
GGO: 101150176(CRYL1)
PON: 100171829(CRYL1)
NLE: 100592398(CRYL1)
MCC: 703988(CRYL1)
MCF: 102126962(CRYL1)
CSAB: 103248964(CRYL1)
RRO: 104653941(CRYL1)
RBB: 108519944(CRYL1)
CJC: 100412249(CRYL1)
SBQ: 101053731(CRYL1)
MMU: 68631(Cryl1)
RNO: 290277(Cryl1)
CGE: 100763866(Cryl1)
NGI: 103726723(Cryl1)
HGL: 101708457(Cryl1)
CCAN: 109695277(Cryl1)
OCU: 100009108(CRYL1)
TUP: 102481339(CRYL1)
CFA: 486050(CRYL1)
AML: 100472061(CRYL1)
UMR: 103664279(CRYL1)
ORO: 101365710(CRYL1)
FCA: 101092816(CRYL1)
PTG: 102950829(CRYL1)
AJU: 106979799(CRYL1)
BTA: 281725(CRYL1)
BOM: 102271200(CRYL1)
BIU: 109567054(CRYL1)
PHD: 102332401(CRYL1)
CHX: 102170708(CRYL1)
OAS: 101118708(CRYL1)
SSC: 396914(CRYL1)
CFR: 102509868(CRYL1)
CDK: 105096393(CRYL1)
BACU: 103009238(CRYL1)
LVE: 103070582(CRYL1)
OOR: 101286495(CRYL1)
ECB: 100054141(CRYL1)
EPZ: 103564931(CRYL1)
EAI: 106828569(CRYL1)
MYB: 102243403(CRYL1)
MYD: 102772105(CRYL1)
HAI: 109388026(CRYL1)
RSS: 109436831(CRYL1)
PALE: 102894030(CRYL1)
LAV: 100659835(CRYL1)
TMU: 101345413
MDO: 100023498(CRYL1)
SHR: 100916381 100917581(CRYL1)
OAA: 100089465(CRYL1)
GGA: 418953(CRYL1)
MGP: 100551040(CRYL1)
CJO: 107308329(CRYL1)
APLA: 101793734(CRYL1)
ACYG: 106040376(CRYL1)
TGU: 100232047(CRYL1)
GFR: 102041430(CRYL1)
FAB: 101817119(CRYL1)
PHI: 102101871(CRYL1)
PMAJ: 107209122(CRYL1)
CCAE: 111923791(CRYL1)
CCW: 104690100(CRYL1)
FPG: 101922282(CRYL1)
FCH: 102049266(CRYL1)
CLV: 102083838(CRYL1)
EGZ: 104134722(CRYL1)
AAM: 106500417(CRYL1)
ASN: 102385817(CRYL1)
AMJ: 102567690(CRYL1)
PSS: 102463965(CRYL1)
CMY: 102935894(CRYL1)
CPIC: 101933946(CRYL1)
ACS: 100564118(cryl1)
PVT: 110083538(CRYL1)
PBI: 103051802(CRYL1)
GJA: 107125996(CRYL1)
XLA: 100036971(cryl1.L) 108709973(cryl1.S)
XTR: 100145620(cryl1)
NPR: 108785578(CRYL1)
DRE: 751596(cryl1)
IPU: 100528270(cryl1)
AMEX: 103023213(cryl1)
TRU: 101068058(cryl1)
LCO: 104934840(cryl1)
NCC: 104945644(cryl1)
OLA: 101157739(cryl1)
XMA: 102230923(cryl1)
PRET: 103478202(cryl1)
NFU: 107389625(cryl1)
KMR: 108244181(cryl1)
CSEM: 103391958(cryl1)
LCF: 108897026(cryl1)
SDU: 111218259(cryl1)
HCQ: 109522065(cryl1)
BPEC: 110162057(cryl1)
MALB: 109970945(cryl1)
SASA: 100195418(cryl1)
OTW: 112240524(cryl1)
ELS: 105016416(cryl1)
SFM: 108937705(cryl1)
LCM: 102362253(CRYL1)
CMK: 103186496(cryl1)
CIN: 100176260
SPU: 589657
SKO: 100374307
DME: Dmel_CG10131(CG10131) Dmel_CG9914(CG9914)
DPE: 6603093
DSI: Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
AAG: 5569895
AME: 406119(Cryl1)
BIM: 100742533
BTER: 100650820
SOC: 105195706
AEC: 105144455
ACEP: 105622538
PBAR: 105431786
HST: 105183285
DQU: 106741081
CFO: 105257467
LHU: 105668733
PGC: 109852151
PCF: 106785654
NVI: 100116345
MDL: 103573914
TCA: 656318
DPA: 109541128
NVL: 108558442
BMOR: 101740023
PMAC: 106716619
PRAP: 110996894
HAW: 110375292
API: 100160442
DNX: 107163082
CLEC: 106668054
ZNE: 110836645
FCD: 110850841
CEL: CELE_Y71F9B.9(Y71F9B.9)
CBR: CBG04121
OBI: 106873772
EPA: 110235936
ADF: 107344229
HMG: 100202070
AQU: 100640580
 » show all
Taxonomy
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim Pol 11:269-277 (1964)
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J Biol Chem 236:357-364 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7

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