KEGG   ENZYME: 1.1.1.48Help
Entry
EC 1.1.1.48                 Enzyme                                 

Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00035  D-galactose 1-dehydrogenase
K22215  galactose dehydrogenase
Genes
XCC: XCC0744(dgd)
XCB: XC_3491
XCA: xcc-b100_3611
XCP: XCR_0916
XCV: XCV0847
XAX: XACM_0792
XAC: XAC0797(dgd)
XCI: XCAW_03785(dgd)
XCT: J151_00922
XCJ: J158_00919
XOO: XOO3804(dgd)
XOM: XOO3586(XOO3586)
XOP: PXO_04345
XOR: XOC_0862
XPH: XppCFBP6546_07460(XppCFBP6546P_07460)
PST: PSPTO_4782(gal)
PSB: Psyr_4331
PSP: PSPPH_4371(gal)
CSA: Csal_1017
HEL: HELO_2796(araA)
HAM: HALO0848
SALN: SALB1_2572
DEU: DBW_1406
AMIH: CO731_00808(kduD_1)
SME: SMc00588(gal) SMc00880
SMX: SM11_chr0479(fabG2) SM11_chr2506(gal)
SMEL: SM2011_c00588(gal) SM2011_c00880(fabG2)
SFH: SFHH103_00504(fabg1) SFHH103_00835(gal)
SFD: USDA257_c05370(bacC1) USDA257_c08790(gal)
ATU: Atu0705(fabG) Atu1113
ARA: Arad_1105(fabG1) Arad_1691(gal)
ATF: Ach5_06290(fabG) Ach5_10290(gal)
AVI: Avi_3910
RET: RHE_CH00855(fabG1) RHE_CH01458(gal)
RHL: LPU83_0965(fabG1) LPU83_1415(gal)
RHT: NT26_2220 NT26_3705(fabG)
BME: BMEII0355
BMEL: DK63_2884
BMEE: DK62_2513
BMF: BAB2_0293
BABO: DK55_2285
BABR: DO74_2705
BABT: DK49_2946
BABB: DK48_2407
BABU: DK53_2296
BABS: DK51_2874
BABC: DO78_2765
BMS: BRA0941
BSZ: DK67_2894
BOV: BOV_A0883
BCS: BCAN_B0961(gal)
BCAR: DK60_2632
BCAS: DA85_14990
BMR: BMI_II935
OAN: Oant_1420
OAH: DR92_986
OCH: CES85_1890(gal)
BJA: blr3205
BRA: BRADO1814
BBT: BBta_2134
BRS: S23_47920
AOL: S58_57220
BRAD: BF49_1480
SNO: Snov_0117
MET: M446_4632
MOR: MOC_1687
BID: Bind_3077
PHL: KKY_220
CCR: CC_0967
RSP: RSP_1369
JAN: Jann_3834
RDE: RD1_2866
PDE: Pden_4245
PAMN: pAMV1p0045(araA)
DSH: Dshi_1243
PSF: PSE_2806
PGD: Gal_02755
OAT: OAN307_c48590(gal)
OAR: OA238_c48520(gal)
OTM: OSB_32620(araA)
SPSE: SULPSESMR1_02141(xylB)
RMM: ROSMUCSMR3_00498(xylB)
SAL: Sala_0745
SPHK: SKP52_01885(araA)
SPHU: SPPYR_0433(araA)
SPHM: G432_06460
STAX: MC45_07850
SPHI: TS85_21120
SINB: SIDU_10715
AAY: WYH_02192(araA)
ADO: A6F68_00759(araA)
AZL: AZL_e03690(gal)
TMO: TMO_a0253
 » show all
Taxonomy
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J Biol Chem 227:745-57 (1957)
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.48
IUBMB Enzyme Nomenclature: 1.1.1.48
ExPASy - ENZYME nomenclature database: 1.1.1.48
BRENDA, the Enzyme Database: 1.1.1.48
CAS: 9028-54-0

DBGET integrated database retrieval system