| Entry |
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| Name |
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
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| Reaction(IUBMB) |
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN: R10422 R10423]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
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| History |
EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
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| Pathway |
| ec00120 | Primary bile acid biosynthesis |
| ec00140 | Steroid hormone biosynthesis |
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| Orthology |
| K00037 | 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase |
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| Genes |
» show all
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| Reference |
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| Authors |
JARABAK J, TALALAY P. |
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| Title |
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases. |
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| Journal |
J Biol Chem 235:2147-51 (1960) |
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| Reference |
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| Authors |
KOCHAKIAN CD, CARROLL BR, UHRI B. |
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| Title |
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates. |
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| Journal |
J Biol Chem 224:811-8 (1957) |
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| Reference |
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| Authors |
MARCUS PI, TALALAY P. |
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| Title |
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases. |
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| Journal |
J Biol Chem 218:661-74 (1956) |
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| Reference |
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| Authors |
Penning TM, Sharp RB. |
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| Title |
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.50 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.50 |
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