| Entry |
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| Name |
3alpha(or 20beta)-hydroxysteroid dehydrogenase;
cortisone reductase;
(R)-20-hydroxysteroid dehydrogenase;
dehydrogenase, 20beta-hydroxy steroid;
Delta4-3-ketosteroid hydrogenase;
20beta-hydroxysteroid dehydrogenase;
3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase;
NADH-20beta-hydroxysteroid dehydrogenase;
20beta-HSD
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
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| Reaction(IUBMB) |
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ [RN: R04330]
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| Reaction(KEGG) |
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| Substrate |
androstan-3alpha,17beta-diol [CPD: C03852];
NAD+ [CPD: C00003]
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| Product |
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| Comment |
The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor.
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| History |
EC 1.1.1.53 created 1961, modified 1986
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| Pathway |
| ec00140 | Steroid hormone biosynthesis |
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| Orthology |
| K00038 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Edwards CA, Orr JC. |
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| Title |
Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans. |
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| Journal |
Biochemistry 17:4370-6 (1978) |
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| Reference |
|
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| Authors |
HUEBENER HJ, SAHRHOLZ FG |
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| Title |
[20 beta-Hydroxysteroid dehydrogenase. 2. Preparation and crystallization.] |
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| Journal |
Biochem Z 333:95-105 (1960) |
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| Reference |
|
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| Authors |
HUEBENER HJ, SAHRHOLZ FG, SCHMIDT-THOME J, NESEMANN G, JUNK R |
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| Title |
[20 beta-Hydroxysteroid dehydrogenase, a new crystalline enzyme.] |
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| Journal |
Biochim Biophys Acta 35:270-2 (1959) |
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| Reference |
|
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| Authors |
LYNN WS Jr, BROWN RH. |
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| Title |
The conversion of progesterone to androgens by testes. |
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| Journal |
J Biol Chem 232:1015-30 (1958) |
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| Reference |
|
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| Authors |
Strickler RC, Covey DF, Tobias B. |
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| Title |
Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site. |
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| Journal |
Biochemistry 19:4950-4 (1980) |
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| Reference |
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| Authors |
Sweet F, Samant BR. |
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| Title |
Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids. |
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| Journal |
Biochemistry 19:978-86 (1980) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.53 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.53 |
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