Entry |
|
Name |
3alpha(or 20beta)-hydroxysteroid dehydrogenase;
cortisone reductase;
(R)-20-hydroxysteroid dehydrogenase;
20beta-hydroxy steroid dehydrogenase;
Delta4-3-ketosteroid hydrogenase;
20beta-hydroxysteroid dehydrogenase;
3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase;
NADH-20beta-hydroxysteroid dehydrogenase;
20beta-HSD
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
|
Reaction(IUBMB) |
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ [RN: R04330]
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Reaction(KEGG) |
|
Substrate |
androstan-3alpha,17beta-diol [CPD: C03852];
NAD+ [CPD: C00003]
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Product |
|
Comment |
The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor.
|
History |
EC 1.1.1.53 created 1961, modified 1986
|
Pathway |
ec00140 | Steroid hormone biosynthesis |
|
Orthology |
K00038 | 3alpha(or 20beta)-hydroxysteroid dehydrogenase |
|
Genes |
» show all
|
Reference |
|
Authors |
Edwards CA, Orr JC. |
Title |
Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans. |
Journal |
|
Reference |
|
Authors |
HUEBENER HJ, SAHRHOLZ FG |
Title |
[20 beta-Hydroxysteroid dehydrogenase. 2. Preparation and crystallization.] |
Journal |
Biochem Z 333:95-105 (1960) |
Reference |
|
Authors |
HUEBENER HJ, SAHRHOLZ FG, SCHMIDT-THOME J, NESEMANN G, JUNK R |
Title |
[20 beta-Hydroxysteroid dehydrogenase, a new crystalline enzyme.] |
Journal |
|
Reference |
|
Authors |
LYNN WS Jr, BROWN RH. |
Title |
The conversion of progesterone to androgens by testes. |
Journal |
J Biol Chem 232:1015-30 (1958) |
Reference |
|
Authors |
Strickler RC, Covey DF, Tobias B. |
Title |
Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site. |
Journal |
|
Reference |
|
Authors |
Sweet F, Samant BR |
Title |
Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 1.1.1.53 |
ExPASy - ENZYME nomenclature database: | 1.1.1.53 |
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