KEGG   ENZYME: 1.1.1.8Help
Entry
EC 1.1.1.8                  Enzyme                                 

Name
glycerol-3-phosphate dehydrogenase (NAD+);
alpha-glycerol phosphate dehydrogenase (NAD+);
alpha-glycerophosphate dehydrogenase (NAD+);
glycerol 1-phosphate dehydrogenase;
glycerol phosphate dehydrogenase (NAD+);
glycerophosphate dehydrogenase (NAD+);
hydroglycerophosphate dehydrogenase;
L-alpha-glycerol phosphate dehydrogenase;
L-alpha-glycerophosphate dehydrogenase;
L-glycerol phosphate dehydrogenase;
L-glycerophosphate dehydrogenase (ambiguous);
NAD+-alpha-glycerophosphate dehydrogenase;
NAD+-dependent glycerol phosphate dehydrogenase;
NAD+-dependent glycerol-3-phosphate dehydrogenase;
NAD+-L-glycerol-3-phosphate dehydrogenase;
NAD+-linked glycerol 3-phosphate dehydrogenase;
NADH-dihydroxyacetone phosphate reductase;
glycerol-3-phosphate dehydrogenase (NAD+);
L-glycerol-3-phosphate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
Reaction(IUBMB)
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ [RN:R00842]
Reaction(KEGG)
Substrate
sn-glycerol 3-phosphate [CPD:C00093];
NAD+ [CPD:C00003]
Product
glycerone phosphate [CPD:C00111];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
History
EC 1.1.1.8 created 1961, modified 2005
Pathway
ec00564  Glycerophospholipid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K00006  glycerol-3-phosphate dehydrogenase (NAD+)
Genes
HSA: 23171(GPD1L) 2819(GPD1)
PTR: 741054(GPD1) 750218(GPD1L)
PPS: 100981359(GPD1) 100983363(GPD1L)
GGO: 101131184(GPD1) 101153797(GPD1L) 109025533
PON: 100172201(GPD1) 100173675(GPD1L)
NLE: 100590911(GPD1L) 100594138(GPD1)
MCC: 707723(GPD1L)
MCF: 101865501(GPD1) 102127578(GPD1L)
CSAB: 103238296(GPD1) 103241822(GPD1L)
RRO: 104655077(GPD1L) 104679694(GPD1)
RBB: 108539186(GPD1L) 108543924(GPD1)
CJC: 100392024(GPD1L) 100414900(GPD1)
SBQ: 101030263(GPD1)
MMU: 14555(Gpd1) 333433(Gpd1l)
RNO: 363159(Gpd1l) 60666(Gpd1)
CGE: 100772179(Gpd1) 100773663(Gpd1l)
NGI: 103728538 103731958(Gpd1l) 103746543(Gpd1)
HGL: 101702723(Gpd1) 101707148(Gpd1l)
CCAN: 109695417(Gpd1) 109699959(Gpd1l)
OCU: 100337994(GPD1L) 100339469(GPD1)
TUP: 102482961(GPD1) 102497326(GPD1L)
CFA: 485626(GPD1L) 607942(GPD1)
AML: 100470374(GPD1L) 100473892(GPD1)
UMR: 103675473(GPD1) 103682026(GPD1L)
ORO: 101377180(GPD1L) 101385499(GPD1)
FCA: 101086577(GPD1) 101093135(GPD1L)
PTG: 102953262(GPD1L) 102961238(GPD1)
AJU: 106969233(GPD1) 106984254(GPD1L)
BTA: 514456(GPD1L) 525042(GPD1)
BOM: 102267392(GPD1) 102284896(GPD1L)
BIU: 109559120(GPD1) 109576300(GPD1L)
PHD: 102315535 102319618(GPD1L) 102326635(GPD1)
CHX: 102170471(GPD1L) 102171407(GPD1)
OAS: 101104692(GPD1L) 101119894(GPD1)
SSC: 100153250(GPD1) 100624347(GPD1L)
CFR: 102507052(GPD1) 102516492 102517808(GPD1L)
CDK: 105090736(GPD1L) 105097186(GPD1)
BACU: 103006161 103006680(GPD1) 103017410(GPD1L)
OOR: 101269579(GPD1L) 101277550 101284095(GPD1)
ECB: 100052204(GPD1) 100057124(GPD1L)
EAI: 106822132(GPD1L) 106845052(GPD1)
MYB: 102243576(GPD1L) 102257341(GPD1)
MYD: 102754955(GPD1) 102768327(GPD1L)
HAI: 109375372(GPD1L) 109393253(GPD1)
RSS: 109443801(GPD1) 109445376(GPD1L)
PALE: 102880604(GPD1) 102882609(GPD1L)
LAV: 100660074(GPD1) 100666558(GPD1L) 104846773
MDO: 100021123
SHR: 100928054(GPD1) 100933052
OAA: 100077586(GPD1L) 100085954(GPD1)
GGA: 420664(GPD1L) 424263(GPD1L2)
MGP: 100542199(GPD1) 100547788(GPD1L) 100550137
CJO: 107309298(GPD1L) 107316808 107325705(GPD1)
APLA: 101789855(GPD1) 101797647(GPD1L) 101798440
ACYG: 106029917 106043327(GPD1L) 106047703(GPD1)
GFR: 102037409(GPD1) 102039011(GPD1L) 102043876
FAB: 101809406 101809895(GPD1L) 101814000(GPD1)
PHI: 102105356 102106269(GPD1) 102112664(GPD1L)
PMAJ: 107200748(GPD1L) 107207486 107215690(GPD1)
CCW: 104683744(GPD1) 104689037(GPD1L) 104694034
FPG: 101911770(GPD1) 101914130(GPD1L) 101923280
FCH: 102046404 102047785(GPD1) 102054123(GPD1L)
CLV: 102087722(GPD1L) 102088900(GPD1) 102092172
EGZ: 104122960(GPD1L) 104128126 104132778(GPD1)
AAM: 106491245(GPD1L) 106498487 106499434(GPD1)
ASN: 102371629 102381741(GPD1L) 102383307(GPD1)
AMJ: 102563252(GPD1L) 102571795 102576126(GPD1)
PSS: 102446147(GPD1) 102452438(GPD1L) 102456685
CMY: 102931901 102934050(GPD1L) 102939076(GPD1)
CPIC: 101931423 101935478(GPD1L) 101939497(GPD1)
ACS: 100551913(gpd1l) 100552972(gpd1) 100556166
PVT: 110071835 110074298(GPD1) 110082167(GPD1L)
GJA: 107116500(GPD1L) 107122513(GPD1) 107125582
XLA: 108706115 108709010 379962(gpd1l.L) 399227(gpd1.L) 444456
XTR: 101732858 394623(gpd1l) 448519(gpd1)
NPR: 108789981(GPD1) 108792875(GPD1L) 108803050
DRE: 325181(gpd1b) 406615(gpd1c) 449663(gpd1l) 550404(gpd1a)
TRU: 101066425 101071719(GPD-C) 101079539(gpd1)
CSEM: 103385408 103386748(gpd1) 103388729(gpd1l)
LCM: 102345318(GPD1) 102349298(GPD1L) 102356776
CMK: 103173759 103181235(gpd1l) 103188923(gpd1)
CIN: 100181104
SPU: 763067
APLC: 110976054
DAN: Dana_GF13315 Dana_GF15589(Dana_Gpdh)
DER: Dere_GG20063 Dere_GG25104(Dere_Gpdh)
DPE: Dper_GL11294 Dper_GL19044(Dper_Gpdh)
DSI: Dsimw501_GD23370(Dsim_Gpdh) Dsimw501_GD25078(Dsim_GD25078)
DWI: Dwil_GK14706(Dwil_Gpdh) Dwil_GK19593
DYA: Dyak_GE11600 Dyak_GE25734(Dyak_Gpdh)
AAG: 5571293
AME: 102656448 726445(Gpdh)
NVI: 100123687
TCA: 663884
DPA: 109541497
NVL: 108565769
BMOR: 692517(G3pdh-1)
PMAC: 106717451
PRAP: 111004081
DNX: 107164494
ZNE: 110834796
FCD: 110848094
CEL: CELE_F47G4.3(gpdh-1) CELE_K11H3.1(gpdh-2)
CBR: CBG09958(Cbr-gpdh-2) CBG18871(Cbr-gpdh-1)
BMY: Bm1_45570
TSP: Tsp_09858
MYI: 110460338
LAK: 106175561
ADF: 107350547
HMG: 100200028
AQU: 100637681
ATH: AT2G40690(GLY1) AT2G41540(GPDHC1) AT5G40610(GPDHp)
LJA: Lj0g3v0181499.1(Lj0g3v0181499.1) Lj0g3v0274139.1(Lj0g3v0274139.1) Lj0g3v0274139.2(Lj0g3v0274139.2) Lj0g3v0339029.1(Lj0g3v0339029.1) Lj1g3v4226900.1(Lj1g3v4226900.1)
DOSA: Os01t0801600-01(Os01g0801600) Os01t0939600-01(Os01g0939600) Os01t0971600-01(Os01g0971600) Os05t0495700-01(Os05g0495700) Os07t0229800-01(Os07g0229800)
ATS: 109732365(LOC109732365) 109744428(LOC109744428) 109753133(LOC109753133) 109764507(LOC109764507) 109783732(LOC109783732) 109784079(LOC109784079)
APRO: F751_6745
SCE: YDL022W(GPD1) YOL059W(GPD2)
ERC: Ecym_5243
KMX: KLMA_10179(GPD1)
NCS: NCAS_0C03620(NCAS0C03620) NCAS_0I02050(NCAS0I02050)
NDI: NDAI_0A06640(NDAI0A06640) NDAI_0G02970(NDAI0G02970)
TPF: TPHA_0H00810(TPHA0H00810) TPHA_0P00620(TPHA0P00620)
TBL: TBLA_0B01610(TBLA0B01610) TBLA_0F00800(TBLA0F00800)
TDL: TDEL_0D04540(TDEL0D04540)
KAF: KAFR_0C01000(KAFR0C01000) KAFR_0F02240(KAFR0F02240)
PIC: PICST_83071(GPD2) PICST_90446(GPD1)
SLB: AWJ20_1513(GPD2)
NCR: NCU00742
NTE: NEUTE1DRAFT89817(NEUTE1DRAFT_89817)
MGR: MGG_00067
TRE: TRIREDRAFT_2574(gfd1)
MAW: MAC_03958
MAJ: MAA_06993
CMT: CCM_03540
MBE: MBM_04878
ANG: ANI_1_1768134(An15g07390) ANI_1_786014(An01g06110)
PBL: PAAG_12155(PAAG_06099) PAAG_12156(PAAG_06099)
ABE: ARB_07180
TVE: TRV_07706
PTE: PTT_06868
SPO: SPAC23D3.04c(gpd2) SPBC215.05(gpd1)
WSE: WALSEDRAFT_33541(GPD1/GPD2)
MGL: MGL_2451
PYO: PY17X_0934900(PY00789) PY17X_1434200(PY05585)
PCB: PCHAS_091140(PC000289.03.0) PCHAS_143390(PC000530.03.0)
TAN: TA21330
TPV: TP01_0302
BBO: BBOV_IV004480(23.m06005)
CPV: cgd2_210
SMIN: v1.2.007763.t1(symbB.v1.2.007763.t1) v1.2.023482.t1(symbB.v1.2.023482.t1) v1.2.029470.t1(symbB.v1.2.029470.t1) v1.2.031301.t1(symbB.v1.2.031301.t1) v1.2.033457.t1(symbB.v1.2.033457.t1)
LMA: LMJF_10_0510(GPD)
LIF: LINJ_10_0560(GPD)
LBZ: LBRM_10_0640(GPD)
 » show all
Taxonomy
Reference
1
  Authors
Baranowski, T.
  Title
alpha-Glycerophosphate dehydrogenase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 85-96.
Reference
2  [PMID:4307630]
  Authors
Brosemer RW, Kuhn RW.
  Title
Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases.
  Journal
Biochemistry 8:2095-105 (1969)
Reference
3  [PMID:4340553]
  Authors
O'Brien SJ, MacIntyre RJ.
  Title
The  -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects.
  Journal
Biochem Genet 7:141-61 (1972)
Reference
4  [PMID:4200180]
  Authors
Warkentin DL, Fondy TP.
  Title
Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme.
  Journal
Eur J Biochem 36:97-109 (1973)
DOI:10.1111/j.1432-1033.1973.tb02889.x
Reference
5  [PMID:1499720]
  Authors
Albertyn J, van Tonder A, Prior BA.
  Title
Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae.
  Journal
FEBS Lett 308:130-2 (1992)
DOI:10.1016/0014-5793(92)81259-O
Reference
6  [PMID:7671141]
  Authors
Koekemoer TC, Litthauer D, Oelofsen W.
  Title
Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase.
  Journal
Int J Biochem Cell Biol 27:625-32 (1995)
DOI:10.1016/1357-2725(95)00012-E
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.8
IUBMB Enzyme Nomenclature: 1.1.1.8
ExPASy - ENZYME nomenclature database: 1.1.1.8
BRENDA, the Enzyme Database: 1.1.1.8
CAS: 9075-65-4

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