KEGG   ENZYME: 1.1.1.87Help
Entry
EC 1.1.1.87                 Enzyme                                 

Name
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R01934;
(other) R01936 R04862
Show
Substrate
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
NAD+ [CPD:C00003]
Product
2-oxoadipate [CPD:C00322];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Forms part of the lysine biosynthesis pathway in fungi [3].
History
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K05824  homoisocitrate dehydrogenase
K10978  methanogen homoisocitrate dehydrogenase
Genes
SCE: YIL094C(LYS12)
AGO: AGOS_ADL214C
ERC: Ecym_3326
KLA: KLLA0_E08339g
KMX: KLMA_80130(LYS12)
LTH: KLTH0G10384g
VPO: Kpol_1003p39
ZRO: ZYRO0A01914g
CGR: CAGL0G02585g
NCS: NCAS_0B06250(NCAS0B06250)
NDI: NDAI_0B03550(NDAI0B03550)
TPF: TPHA_0C03410(TPHA0C03410)
TBL: TBLA_0B05940(TBLA0B05940)
TDL: TDEL_0G02180(TDEL0G02180)
KAF: KAFR_0J01360(KAFR0J01360)
PIC: PICST_50442(LYS12)
CAL: CAALFM_CR01400WA(LYS12)
CAUR: QG37_01618
SLB: AWJ20_5129(LYS12)
NCR: NCU02954(lys-7)
NTE: NEUTE1DRAFT119171(NEUTE1DRAFT_119171)
MGR: MGG_01566
SSCK: SPSK_09424
MAW: MAC_01875
MAJ: MAA_00573
CMT: CCM_06018
MBE: MBM_09266
ANI: AN5206.2
ANG: ANI_1_398134(An15g02490)
ABE: ARB_06194
TVE: TRV_01663
PTE: PTT_19273
CNE: CND03850
CNB: CNBD2460
ABP: AGABI1DRAFT113649(AGABI1DRAFT_113649)
ABV: AGABI2DRAFT191701(AGABI2DRAFT_191701)
MGL: MGL_3003
PCQ: PcP3B5_09520(hicd)
PKC: PKB_4900(leub3)
PSET: THL1_4856
RCA: Rcas_3471
CAU: Caur_0331
CAG: Cagg_3600
HAU: Haur_3304
ATM: ANT_08240
DRA: DR_1674
DGE: Dgeo_1458
TRA: Trad_2841
TTH: TT_C1012
TTJ: TTHA1378
TSC: TSC_c20650(icd2)
TAQ: TO73_0559
MRB: Mrub_2738
MJA: MJ_1596
MMP: MMP0880(aksF)
MMD: GYY_05110
MAE: Maeo_1484
MVO: Mvol_0791
MTH: MTH_184
METC: MTCT_0151
MWO: MWSIV6_0600(leuB1)
METE: tca_00168(hicd_1)
MST: Msp_0674
MSI: Msm_0373
MRU: mru_1033(aksF)
MEB: Abm4_0999(aksF)
MMIL: sm9_0644(aksF)
MEYE: TL18_03130
MOL: YLM1_0578
METH: MBMB1_1404(leuB1)
MFC: BRM9_0639(aksF)
MFI: DSM1535_0612(leuB1)
MCUB: MCBB_1645(leuB1)
MFV: Mfer_1273
MKA: MK1215(leuB_2)
MAC: MA_3748(leuB)
MBAR: MSBR2_2662
MBAK: MSBR3_2764
MMA: MM_0642
MMAC: MSMAC_0669
METM: MSMTP_0734
MTHE: MSTHC_0902
MTHR: MSTHT_2378
MHOR: MSHOH_0789
MMET: MCMEM_2087
MMH: Mmah_0129
MPY: Mpsy_2352
MTP: Mthe_0855
MCJ: MCON_1920(aksF)
MHI: Mhar_2394
MHU: Mhun_1797
MLA: Mlab_0235
MBG: BN140_3039(leuB3)
MEMA: MMAB1_2207(leuB)
MPI: Mpet_2492
MBN: Mboo_0602
MPL: Mpal_2146
MPD: MCP_1963(aksF)
MEZ: Mtc_1557(aksF)
RCI: RCIX2644(leuB-2)
 » show all
Taxonomy
Reference
1  [PMID:4284830]
  Authors
Strassman M, Ceci LN.
  Title
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
  Journal
J Biol Chem 240:4357-61 (1965)
Reference
2  [PMID:4395693]
  Authors
Rowley B, Tucci AF.
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
Reference
3  [PMID:10714900]
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.87
IUBMB Enzyme Nomenclature: 1.1.1.87
ExPASy - ENZYME nomenclature database: 1.1.1.87
BRENDA, the Enzyme Database: 1.1.1.87
CAS: 9067-90-7

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