| Entry |
|
|---|
| Name |
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl CoA-reductase (ambiguous);
3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl coenzyme A reductase (ambiguous)
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|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
|
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| Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN: R02081]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| History |
EC 1.1.1.88 created 1972, modified 2002
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| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
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| Orthology |
| K00054 | hydroxymethylglutaryl-CoA reductase |
|
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| Genes |
» show all
|
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| Reference |
1 |
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| Authors |
Fimognari, G.M. and Rodwell, V.W. |
|---|
| Title |
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). |
|---|
| Journal |
Biochemistry 4:2086-2090 (1965) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.88 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.88 |
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