| Entry |
|
|---|
| Name |
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl CoA-reductase (ambiguous);
3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl coenzyme A reductase (ambiguous)
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
|---|
| Sysname |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
|
|---|
| Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN: R02081]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| History |
EC 1.1.1.88 created 1972, modified 2002
|
|---|
| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K00054 | hydroxymethylglutaryl-CoA reductase |
|
|---|
| Genes |
| PTAE: | NCTC10697_02276(mvaA) |
| LFA: | LFA_1198(hmgA) LFA_2262(mvaA) |
| LLG: | 44548918_02234(mvaA) |
| LJR: | NCTC11533_02313(mvaA) |
| LCJ: | NCTC11976_02826(mvaA) |
| LWA: | SAMEA4504053_2305(mvaA_1) SAMEA4504053_2440(mvaA_2) |
| LSS: | NCTC12082_01446(mvaA) |
| LADL: | NCTC12735_01483(mvaA) |
| AXX: | ERS451415_03082(mvaA) |
| MSD: | MYSTI_05245 MYSTI_05505 |
| MFB: | MFUL124B02_01470 MFUL124B02_11615 MFUL124B02_14135 MFUL124B02_28770 MFUL124B02_30010 |
| AGE: | AA314_01868 AA314_03811 |
| AVM: | JQX13_22175 JQX13_33160 |
| MBD: | MEBOL_004335 MEBOL_005713 |
| PAUU: | E8A73_032560 E8A73_039820 |
| SAMY: | DB32_000804 DB32_006294 |
| BSED: | DN745_02575 DN745_02590 |
| MAQU: | Maq22A_c21635(hmg1) |
| SPSE: | SULPSESMR1_00707(mvaA) |
| PPRU: | FDP22_15890 FDP22_19260 |
| VIL: | CFK37_04990 CFK37_10080 |
| VNE: | CFK40_00660 CFK40_05840 |
| LAO: | AOX59_08350 AOX59_12535 |
| SUX: | SAEMRSA15_24480(mvaA) |
| SUF: | SARLGA251_23200(mvaA) |
| SAUT: | SAI1T1_2018940(mvaA) |
| SAUJ: | SAI2T2_1018950(mvaA) |
| SAUK: | SAI3T3_1018940(mvaA) |
| SAUQ: | SAI4T8_1018950(mvaA) |
| SPIC: | SAMEA4384060_0646(mvaA) |
| SSH: | NCTC13712_02499(mvaA) |
| SSIM: | SAMEA4384339_2347(mvaA) |
| GMO: | NCTC11323_00064(mvaA) |
| GHA: | NCTC10459_01687(mvaA) |
| STG: | MGAS15252_0711(mvaS1) |
| STX: | MGAS1882_0707(mvaS1) |
| SNV: | SPNINV200_15480(mvaA) |
| SPNG: | HMPREF1038_01706(mvaA) |
| SPNE: | SPN034156_06050(mvaA) |
| SPNU: | SPN034183_15150(mvaA) |
| SPNM: | SPN994038_15040(mvaA) |
| SPNO: | SPN994039_15050(mvaA) |
| SMC: | SmuNN2025_1085(mvaA) |
| SGG: | SGGBAA2069_c12510(mvaA) |
| STRG: | SRT_11520(mvaA) SRT_11530(mvaA) |
| SVB: | NCTC12167_00608(mvaA) |
| SMEN: | SAMEA4412692_1229(mvaA) |
| SFER: | NCTC12278_01037(mvaA) |
| SCAI: | NCTC12191_01809(mvaA) |
| SPSU: | NCTC13786_02079(mvaA) |
| SPOC: | NCTC10925_01058(mvaA) |
| SAUP: | NCTC3168_01009(mvaA) |
| SURN: | NCTC13766_00981(mvaA) |
| SVF: | NCTC3166_01739(mvaA) |
| LPW: | LpgJCM5343_13710(mvaA) |
| LOR: | AYI71_00910 AYI71_08400 |
| ECEC: | NCTC12421_01572(atoB) |
| AHK: | NCTC10172_00895(mvaA) |
| BAFH: | BafHLJ01_0755(mvaA) |
| SPON: | HME9304_01002(mvaA) |
| AALG: | AREALGSMS7_00744(mvaA) |
| KOS: | KORDIASMS9_00482(mvaA) |
| KAN: | IMCC3317_23820(mvaA) |
| CGLE: | NCTC11432_02579(mvaA) |
| CTAI: | NCTC12078_01185(mvaA) |
| CTAK: | 4412677_02320(mvaA) |
| CJG: | NCTC13459_02490(mvaA) |
| CANT: | NCTC13489_02506(mvaA) |
| TVO: | TVG1221182(TVG1221182) |
| BARC: | AOA65_0748 AOA65_0762(hmgA) |
| LOKI: | Lokiarch_22660(mvaA) |
|
|---|
| Reference |
1 |
|---|
| Authors |
Fimognari, G.M. and Rodwell, V.W. |
|---|
| Title |
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). |
|---|
| Journal |
Biochemistry 4:2086-2090 (1965) |
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.88 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.88 |
|
|---|
