| Entry |
|
|---|
| Name |
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase;
beta-hydroxy-beta-methylglutaryl CoA-reductase;
3-hydroxy-3-methylglutaryl coenzyme A reductase;
hydroxymethylglutaryl coenzyme A reductase
|
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
|
|---|
| Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN: R02081]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| History |
EC 1.1.1.88 created 1972, modified 2002
|
|---|
| Pathway |
| ec00900 | Terpenoid backbone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01130 | Biosynthesis of antibiotics |
|
|---|
| Orthology |
| K00054 | hydroxymethylglutaryl-CoA reductase |
|
|---|
| Genes |
» show all
 |
|---|
| Reference |
1 |
|---|
| Authors |
Fimognari, G.M. and Rodwell, V.W. |
|---|
| Title |
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). |
|---|
| Journal |
Biochemistry 4:2086-2090 (1965) |
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.88 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.88 |
|
|---|
