KEGG   ENZYME: 1.1.1.88Help
Entry
EC 1.1.1.88                 Enzyme                                 

Name
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase;
beta-hydroxy-beta-methylglutaryl CoA-reductase;
3-hydroxy-3-methylglutaryl coenzyme A reductase;
hydroxymethylglutaryl coenzyme A reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN:R02081]
Reaction(KEGG)
Substrate
(R)-mevalonate [CPD:C00418];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
3-hydroxy-3-methylglutaryl-CoA [CPD:C00356];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.1.1.88 created 1972, modified 2002
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K00054  hydroxymethylglutaryl-CoA reductase
Genes
STEK: AXG53_08000
RHD: R2APBS1_3947
PCQ: PcP3B5_30960(mvaA)
PPF: Pput_3073
PPI: YSA_09663
PSTT: CH92_10110
PBC: CD58_17890
PFZ: AV641_12965
PPSY: AOC04_09630
PALI: A3K91_0944
MBS: MRBBS_1941(mvaA)
LPN: lpg2052
LPH: LPV_2355(mvaA)
LPO: LPO_2155(mvaA)
LPM: LP6_2032(mvaA)
LPF: lpl2030
LPP: lpp2035
LPC: LPC_1538(mvaA)
LPA: lpa_02994
LPE: lp12_1993
LLO: LLO_2093(mvaA)
LFA: LFA_1198(hmgA) LFA_2262(mvaA)
LHA: LHA_2668(hmgA)
LOK: Loa_02632
LCD: clem_02920(mvaA)
LLG: 44548918_02234(mvaA)
TMC: LMI_2739(hmgA)
HAM: HALO0597
ADI: B5T_00170
APAC: S7S_00595
AXE: P40_00835
SALN: SALB1_2160
CGD: CR3_3190(mvaA)
BCJ: BCAM0531(mvaA)
BCEO: I35_4422(mvaA)
BCED: DM42_4560
BSEM: WJ12_22645
BGO: BM43_7175
BPT: Bpet3342(mvaA)
AXX: ERS451415_03082(mvaA)
PUT: PT7_1301
AMIM: MIM_c08330(hmgA1)
DAC: Daci_0287
HYB: Q5W_13825
HSE: Hsero_3034(mvaA)
HRB: Hrubri_3051(mvaA)
MXA: MXAN_5020
CCX: COCOR_02446(mvaA)
SCL: sce3010
BBA: Bd1627
BBAT: Bdt_1616
BBW: BDW_05675
BBAC: EP01_04340
BEX: A11Q_1500
BMX: BMS_1477(mvaA)
SHZ: shn_25545
MAQU: Maq22A_c21635(hmg1)
SIL: SPOA0163(mvaA)
RSU: NHU_01014
SPSE: SULPSESMR1_00707(mvaA)
TMO: TMO_a0224(mvaA)
PGV: SL003B_3247(mvaA)
BCK: BCO26_0196(mvaA)
BAG: Bcoa_1063
BCOA: BF29_2664
OIH: OB0224
AXL: AXY_13140
VPN: A21D_01101(mvaA)
SAU: SA2333(mvaA)
SAV: SAV2545(mvaA)
SAW: SAHV_2529(mvaA)
SAM: MW2466(mvaA)
SAS: SAS2431
SAR: SAR2625(mvaA)
SAC: SACOL2560
SAE: NWMN_2445(mvaA)
SAD: SAAV_2611
SUJ: SAA6159_02441(mvaA)
SUK: SAA6008_02583(mvaA)
SUZ: MS7_2550
SUX: SAEMRSA15_24480(mvaA)
SUW: SATW20_26670(mvaA)
SUG: SAPIG2595
SUF: SARLGA251_23200(mvaA)
SAUA: SAAG_00366
SAUE: RSAU_002385(mvaA)
SAUS: SA40_2297(mvaA)
SAUU: SA957_2381(mvaA)
SAUG: SA268_2459(mvaA)
SAUZ: SAZ172_2644(mvaA)
SAUT: SAI1T1_2018940(mvaA)
SAUJ: SAI2T2_1018950(mvaA)
SAUK: SAI3T3_1018940(mvaA)
SAUQ: SAI4T8_1018950(mvaA)
SAUF: X998_2528
SAB: SAB2419c(mvaA)
SUY: SA2981_2481(mvaA)
SAUB: C248_2602(mvaA)
SAUC: CA347_2619
SAUR: SABB_01137(mvaA)
SAUI: AZ30_13340
SAUD: CH52_06275
SAMS: NI36_12725
SEP: SE2109
SER: SERP2121
SEPP: SEB_02114
SEPS: DP17_1049
SHA: SH0511(mvaA)
SHH: ShL2_00409(mvaA)
SSP: SSP0326
SCA: SCA_1883(mvaA)
SLN: SLUG_04440(mvaA)
SPAS: STP1_1045
SXO: SXYL_00360(mvaA)
SCAP: AYP1020_1714(mvaA)
LMO: lmo0825
LMOE: BN418_0971
LMOB: BN419_0975
LMOD: LMON_0829
LMOW: AX10_12665
LMOQ: LM6179_1139(mvaA)
LMR: LMR479A_0843(mvaA)
LMOM: IJ09_06205
LMOG: BN389_08550(mvaA)
LMP: MUO_04395
LMOX: AX24_01440
LMQ: LMM7_0856(mvaA)
LMS: LMLG_2491
LMOK: CQ02_04315
LIN: lin0821
LWE: lwe0819(mvaA)
LSG: lse_0725
LIV: LIV_0764
GMO: NCTC11323_00064(mvaA)
LLA: L10433(mvaA)
LLK: LLKF_1694(mvaA)
LLT: CVCAS_1478(mvaA)
LLS: lilo_1494(mvaA)
LLX: NCDO2118_1591(mvaA)
LLC: LACR_1664
LLM: llmg_0931(mvaA)
LLR: llh_4680
LLI: uc509_1525(mvaA)
LLW: kw2_1526
LLJ: LG36_1520(mvaA)
LGR: LCGT_1220
LGV: LCGL_1241
SPY: SPy_0880(mvaS.1)
SPYA: A20_0727c(mvaS.1)
SPM: spyM18_0941(mvaS1)
SPG: SpyM3_0599(mvaS.1)
SPS: SPs1254
SPF: SpyM51122(mvaA)
STG: MGAS15252_0711(mvaS1)
STX: MGAS1882_0707(mvaS1)
SOZ: Spy49_0694c(mvaS1)
SPYH: L897_03595
SPN: SP_1726
SPD: SPD_1536
SPR: spr1570(mvaA)
SPW: SPCG_1698(mvaA)
SJJ: SPJ_1621
SNV: SPNINV200_15480(mvaA)
SPX: SPG_1631(mvaA)
SNT: SPT_1664
SND: MYY_1645
SPNN: T308_07880
SNE: SPN23F17270(mvaA)
SPV: SPH_1835
SNI: INV104_14710(mvaA)
SPNG: HMPREF1038_01706(mvaA)
SNP: SPAP_1731
SNX: SPNOXC15180(mvaA)
SNU: SPNA45_00517(mvaA)
SPNE: SPN034156_06050(mvaA)
SPNU: SPN034183_15150(mvaA)
SPNM: SPN994038_15040(mvaA)
SPNO: SPN994039_15050(mvaA)
SAG: SAG1317
SAN: gbs1387
SAK: SAK_1348
SGC: A964_1231
SAGM: BSA_13960
SAGI: MSA_14380
SAGR: SAIL_13620
SAGP: V193_05815
SAGC: DN94_05815
SAGE: EN72_07345
SAGG: EN73_06475
SAGN: W903_1330
SMU: SMU_942(mvaA)
SMC: SmuNN2025_1085(mvaA)
SMJ: SMULJ23_1083(mvaA)
SMUA: SMUFR_0820
STC: str0576(mvaA)
STL: stu0576(mvaA)
STE: STER_0620
STN: STND_0576
STU: STH8232_0760(mvaA)
STW: Y1U_C0553
STHE: T303_04035
SSA: SSA_0337(mvaA)
SSB: SSUBM407_1530(mvaA)
SSI: SSU1454(mvaA)
SSS: SSUSC84_1483(mvaA)
SUP: YYK_06950
SST: SSUST3_1488(mvaA)
SSUY: YB51_7335
SSK: SSUD12_1597(mvaA)
SSQ: SSUD9_1651(mvaA)
SRP: SSUST1_1521(mvaA)
SSUT: TL13_1441(mvaA)
SSUI: T15_1655
SGO: SGO_0243
SEZ: Sez_1080(hmgA)
SEQ: SZO_08870
SEQU: Q426_03685
SEU: SEQ_1108
SUB: SUB0769(mvaA)
SDS: SDEG_0842(mvaS1)
SDA: GGS_0809(mvaS1)
SDC: SDSE_0879(mvaA)
SGG: SGGBAA2069_c12510(mvaA)
SGT: SGGB_1254(mvaA)
SMB: smi_1618
SOR: SOR_1536
STK: STP_0604(mvaA)
STB: SGPB_1170(mvaA)
SCF: Spaf_1822(hmg1)
SSR: SALIVB_1511(mvaA)
STJ: SALIVA_0586(mvaA)
SSAH: HSISS4_00495(mvaA)
SMN: SMA_1189(mvaA)
SIF: Sinf_1091
SIE: SCIM_0185(mvaA)
SIB: SIR_0243
SIU: SII_0229
SANG: SAIN_0168
SANC: SANR_0192
SANS: DK43_09280
SCG: SCI_0246
SCON: SCRE_0226
SCOS: SCR2_0226
SIK: K710_1153
SLU: KE3_1153
STRN: SNAG_1501(mvaA)
LPL: lp_0447(mvaA)
LPJ: JDM1_0375(mvaA)
LPT: zj316_0610(mvaA)
LPS: LPST_C0374(mvaA)
LPZ: Lp16_0401
LJO: LJ_1608
LJF: FI9785_1399(mvaA)
LJH: LJP_1347c
LAC: LBA0627(hmdH)
LAD: LA14_0656
LAF: SD55_0651(hmdH)
LSA: LCA_1485(mvaA)
LSL: LSL_0224
LSI: HN6_00218
LDB: Ldb0880(mvaA)
LBU: LBUL_0805
LDL: LBU_0749
LBR: LVIS_0450
LCA: LSEI_1786
LPAP: LBPC_1702
LCB: LCABL_20040(mvaA)
LCS: LCBD_1982
LCE: LC2W_1961
LCW: BN194_19690(mvaA)
LGA: LGAS_1373
LRE: Lreu_0206
LRF: LAR_0196
LRT: LRI_1750
LHE: lhv_0662
LHL: LBHH_1490
LHV: lhe_0591
LHH: LBH_0531
LHD: HUO_08890
LFE: LAF_0181
LFR: LC40_0132
LFF: LBFF_0196
LRH: LGG_01838(mvaA)
LRG: LRHM_1772
LRL: LC705_01821(mvaA)
LRA: LRHK_1814
LCR: LCRIS_00631(mvaA)
LAM: LA2_03245
LBH: Lbuc_1608
LBN: LBUCD034_1666(mvaA)
LKE: WANG_1020
LRM: LRC_04410
LSN: LSA_03920(hmgA)
LAE: LBAT_1227
PPE: PEPE_0258
PPEN: T256_01395
PCE: PECL_85
EFA: EF1364
EFL: EF62_1816
EFI: OG1RF_11152(atoB)
EFS: EFS1_1184
EFQ: DR75_438
EFM: M7W_1579
EHR: EHR_13740
EMU: EMQU_1046
EDU: LIU_06210
THL: TEH_20240(mvaE)
LME: LEUM_0335
LMM: MI1_01420
LMK: LMES_0276
LCI: LCK_00238(mvaA)
LKI: LKI_04880
LGS: LEGAS_1641(mvaA)
WKO: WKK_03895
WCE: WS08_0010
WCT: WS74_0009
CRN: CAR_c19390(mvaA)
CML: BN424_3178(mvaA)
CARC: NY10_1147
JDA: BW727_101330(mvaA)
CCT: CC1_27080
ERH: ERH_0085(mvaA)
ACL: ACL_0223
APAL: BN85412030(mvaA)
AOC: Aocu_12430(mvaA)
RER: RER_34980(mvaA)
REY: O5Y_15990
RHS: A3Q41_04793(mvaA)
NAL: B005_5093
GVG: HMPREF0421_21108(mvaA)
SIJ: SCIP_0385
PDO: PSDT_1156
RCA: Rcas_0981
CAU: Caur_0236
CAG: Cagg_1141
HAU: Haur_3539
ATM: ANT_28820(mvaA)
ABAT: CFX1CAM_0206(mvaA)
CAP: CLDAP_37800(mvaA)
PBF: CFX0092_A1660(hmgA)
WCH: wcw_1117(mvaA)
BBU: BB_0685
BBUR: L144_03365
BGA: BG0708(mvaA)
BGB: KK9_0718(mvaA)
BGN: BgCN_0713
BAF: BAPKO_0729(mvaA)
BAFH: BafHLJ01_0755(mvaA)
BAFT: P612_03540
BAFE: BAFK78_694(mvaA)
BCHI: OY14_03430
BTU: BT0685
BHR: BH0685
BDU: BDU_688(mvaA)
BRE: BRE_691(mvaA)
BCW: Q7M_694
BMIY: RJ61_03360
BPAK: X966_03480
BANE: N187_03380
LBA: Lebu_0850
SMF: Smon_1290
BLQ: L21SP5_00850(mvaA)
MBAS: ALGA_1993
SGN: SGRA_3436
GFO: GFO_2973(hmgA)
GFL: GRFL_1008
FJO: Fjoh_1418
FJG: BB050_01197(mvaA)
FPS: FP2341(mvaA)
FBR: FBFL15_0427(mvaA)
FIN: KQS_01500(mvaA)
ZPR: ZPR_0646
RAI: RA0C_1861
RAR: RIA_0620
RAG: B739_0303
RAE: G148_2020
RAT: M949_0745
MARM: YQ22_05670
CBAL: M667_02450
CBAT: M666_02445
DOK: MED134_00855(mvaA)
DDO: I597_0094(mvaA)
ZGA: ZOBELLIA_1191(mvaA)
MLT: VC82_984
NDO: DDD_2040(hmgA)
EAO: BD94_0681
ELB: VO54_01997(mvaA)
MYR: MYRA21_1563(mvaA)
MPW: MPR_0385
CHZ: CHSO_4259
CTAK: 4412677_02320(mvaA)
WIN: WPG_1915
TMAR: MARIT_2591(mvaA)
AALG: AREALGSMS7_00744(mvaA)
SPON: HME9304_01002(mvaA)
KOS: KORDIASMS9_00482(mvaA)
MARF: CJ739_2286
FBA: FIC_02280
FBU: UJ101_00631(mvaA)
CABY: Cabys_3842
AFU: AF_1736
FPL: Ferp_1542
GAC: GACE_1860
GAH: GAH_00518
TAC: Ta0406
TVO: TVG1221182(TVG1221182)
PTO: PTO1143
FAI: FAD_1189
CDIV: CPM_1100
ABI: Aboo_1461
MTP: Mthe_0936
MCJ: MCON_2640(mvaA)
MHI: Mhar_2045
MPD: MCP_0218(hmgA-1)
MEZ: Mtc_0274(hmgA-1)
RCI: RCIX376(hmgA)
HALH: HTSR_0034
HHSR: HSR6_0034(hmgA)
HSU: HLASF_0036(mvaA)
HSF: HLASA_0036(mvaA)
SMR: Smar_0178
DKA: DKAM_0720
TAG: Tagg_0332
IAG: Igag_1535
TPE: Tpen_0927
NMR: Nmar_1560
NID: NPIRD3C_0092(hmgA)
NIN: NADRNF5_0331(hmgA)
NCT: NMSP_0200(hmgA)
NGA: Ngar_c30640(mvaA)
NVN: NVIE_023590(mvaA)
NEV: NTE_03194
TAA: NMY3_00751(mvaA)
NCV: NCAV_0171(hmgA)
NBV: T478_1287
NDV: NDEV_1923(hmgA)
KCR: Kcr_0563
BARB: AOA66_0364(hmgA)
LOKI: Lokiarch_22660(mvaA)
 » show all
Taxonomy
Reference
1
  Authors
Fimognari, G.M. and Rodwell, V.W.
  Title
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA).
  Journal
Biochemistry 4:2086-2090 (1965)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.88
IUBMB Enzyme Nomenclature: 1.1.1.88
ExPASy - ENZYME nomenclature database: 1.1.1.88
BRENDA, the Enzyme Database: 1.1.1.88
CAS: 37250-24-1

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