KEGG   ENZYME: 1.1.3.13Help
Entry
EC 1.1.3.13                 Enzyme                                 

Name
alcohol oxidase;
ethanol oxidase;
alcohol:oxygen oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
alcohol:oxygen oxidoreductase (H2O2-forming)
Reaction(IUBMB)
a primary alcohol + O2 = an aldehyde + H2O2 [RN:R00637]
Reaction(KEGG)
Substrate
primary alcohol [CPD:C00226];
O2 [CPD:C00007]
Product
aldehyde [CPD:C00071];
H2O2 [CPD:C00027]
Comment
The enzymes from the fungi Candida methanosorbosa and several Basidiomycetes species contain an FAD cofactor [1,3]. The enzyme from the phytopathogenic fungi Colletotrichum graminicola and Colletotrichum gloeosporioides utilize a mononuclear copper-radical mechanism [4]. The enzyme acts on primary alcohols and unsaturated alcohols, and has much lower activity with branched-chain and secondary alcohols.
History
EC 1.1.3.13 created 1972
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K17066  alcohol oxidase
Genes
PPA: PAS_chr4_0152 PAS_chr4_0821
NCR: NCU01853
NTE: NEUTE1DRAFT54808(NEUTE1DRAFT_54808)
SMP: SMAC_06860
PAN: PODANSg3545
TTT: THITE_2049403
MTM: MYCTH_98458
MGR: MGG_09072
TMN: UCRPA7_6115
FGR: FGSG_07530
MAW: MAC_01220
MAJ: MAA_09229
CMT: CCM_09512
MBE: MBM_01886
ANI: AN0567.2
ANG: ANI_1_712164(An18g05480)
PBL: PAAG_01979 PAAG_12459(PAAG_07884) PAAG_12460(PAAG_07884)
PTE: PTT_02545
ABP: AGABI1DRAFT114404(AGABI1DRAFT_114404) AGABI1DRAFT114408(AGABI1DRAFT_114408) AGABI1DRAFT116682(AGABI1DRAFT_116682) AGABI1DRAFT85725(AGABI1DRAFT_85725) AGABI1DRAFT85732(AGABI1DRAFT_85732)
ABV: AGABI2DRAFT191438(AGABI2DRAFT_191438) AGABI2DRAFT191444(AGABI2DRAFT_191444) AGABI2DRAFT191450(AGABI2DRAFT_191450) AGABI2DRAFT195553(AGABI2DRAFT_195553)
 » show all
Taxonomy
Reference
1  [PMID:5636370]
  Authors
Janssen FW, Ruelius HW.
  Title
Alcohol oxidase, a flavoprotein from several Basidiomycetes species. Crystallization by fractional precipitation with polyethylene glycol.
  Journal
Biochim Biophys Acta 151:330-42 (1968)
DOI:10.1016/0005-2744(68)90100-9
Reference
2
  Authors
Nishida, A., Ishihara, T. and Hiroi, T.
  Title
Studies on enzymes related to lignan biodegradation.
  Journal
Baiomasu Henkan Keikaku Kenkyu Hokoku:38-59 (1987)
Reference
3  [PMID:9142745]
  Authors
Suye S.
  Title
Purification and properties of alcohol oxidase from Candida methanosorbosa M-2003.
  Journal
Curr Microbiol 34:374-7 (1997)
Reference
4  [PMID:26680532]
  Authors
Yin DT, Urresti S, Lafond M, Johnston EM, Derikvand F, Ciano L, Berrin JG, Henrissat B, Walton PH, Davies GJ, Brumer H
  Title
Structure-function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family.
  Journal
Nat Commun 6:10197 (2015)
DOI:10.1038/ncomms10197
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.13
IUBMB Enzyme Nomenclature: 1.1.3.13
ExPASy - ENZYME nomenclature database: 1.1.3.13
BRENDA, the Enzyme Database: 1.1.3.13
CAS: 9073-63-6

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