KEGG   ENZYME: 1.1.3.38Help
Entry
EC 1.1.3.38                 Enzyme                                 

Name
vanillyl-alcohol oxidase;
4-hydroxy-2-methoxybenzyl alcohol oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
vanillyl alcohol:oxygen oxidoreductase
Reaction(IUBMB)
vanillyl alcohol + O2 = vanillin + H2O2 [RN:R02877]
Reaction(KEGG)
Substrate
vanillyl alcohol [CPD:C06317];
O2 [CPD:C00007]
Product
vanillin [CPD:C00755];
H2O2 [CPD:C00027]
Comment
Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group.
History
EC 1.1.3.38 created 1999
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20153  vanillyl-alcohol oxidase
Reference
1  [PMID:1396672]
  Authors
de Jong E, van Berkel WJ, van der Zwan RP, de Bont JA.
  Title
Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD.
  Journal
Eur J Biochem 208:651-7 (1992)
DOI:10.1111/j.1432-1033.1992.tb17231.x
  Sequence
Reference
2  [PMID:8529652]
  Authors
Fraaije MW, Veeger C, van Berkel WJ.
  Title
Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols.
  Journal
Eur J Biochem 234:271-7 (1995)
DOI:10.1111/j.1432-1033.1995.271_c.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.38
IUBMB Enzyme Nomenclature: 1.1.3.38
ExPASy - ENZYME nomenclature database: 1.1.3.38
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.3.38
BRENDA, the Enzyme Database: 1.1.3.38
CAS: 143929-24-2

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