KEGG   ENZYME: 1.1.98.3Help
Entry
EC 1.1.98.3                 Enzyme                                 

Name
decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase;
decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase;
Rv3790;
DprE1;
decaprenylphospho-beta-D-ribofuranose 2-oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 [RN:R10112]
Reaction(KEGG)
Substrate
trans,octacis-decaprenylphospho-beta-D-ribofuranose [CPD:C20368];
FAD [CPD:C00016]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:C20369];
FADH2 [CPD:C01352]
Comment
The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.98.3 created 2012, modified 2014
Orthology
K16653  decaprenylphospho-beta-D-ribofuranose 2-oxidase
Genes
SCU: SCE1572_40535
OAT: OAN307_c38650
OAR: OA238_c31740
CID: P73_1220
RSU: NHU_01788
MAGQ: MGMAQ_3649
MTU: Rv3790(dprE1)
MTV: RVBD_3790
MTC: MT3898
MRA: MRA_3830
MTUR: CFBS_4019
MTD: UDA_3790
MTUB: MT7199_3859(dprE1)
MTUE: J114_20240
MTUH: I917_26615
MTUL: TBHG_03728
MTUT: HKBT1_4002
MTUU: HKBT2_4012
MBO: BQ2027_MB3819(dpre1)
MBB: BCG_3852
MBT: JTY_3854
MBX: BCGT_3651
MAF: MAF_38050
MMIC: RN08_4179
MLE: ML0109
MLB: MLBr00109
MPA: MAP_0235c
MAO: MAP4_3636
MAVI: RC58_18075
MAVU: RE97_18110
MAV: MAV_0232
MAVD: NF84_01105
MAVR: LA63_01135
MAVA: LA64_01145
MIT: OCO_02370
MIA: OCU_02430
MID: MIP_00568
MYO: OEM_02480
MIR: OCQ_02370
MLP: MLM_0178
MUL: MUL_4969
MMC: Mmcs_5000
MKM: Mkms_5088
MJL: Mjls_5381
MMI: MMAR_5352
MMM: W7S_01165
MHAD: B586_03115
MVA: Mvan_5627
MGI: Mflv_1178
MPHL: MPHLCCUG_00215(dprE1_1)
MVQ: MYVA_5556
MTHN: 4412656_04392(dprE1_2)
MAB: MAB_0192c
MABB: MASS_0190
MABO: NF82_00965
MCHE: BB28_00990
MSTE: MSTE_00191
MTER: 4434518_04036(dprE1)
ASD: AS9A_0118
CGL: NCgl0187(Cgl0190)
CGB: cg0238
CGU: WA5_0187
CGT: cgR_0269
CGM: cgp_0238
CGJ: AR0_01240
CEF: CE0164
CDI: DIP0162
CDP: CD241_0161(dprE)
CDH: CDB402_0129(dprE)
CDT: CDHC01_0162(dprE)
CDE: CDHC02_0168(dprE)
CDR: CDHC03_0134(dprE)
CDA: CDHC04_0122(dprE)
CDZ: CD31A_0165(dprE)
CDB: CDBH8_0165(dprE)
CDS: CDC7B_0121(dprE)
CDD: CDCE8392_0119(dprE)
CDW: CDPW8_0124(dprE)
CDV: CDVA01_0118(dprE)
CDIP: ERS451417_00129(dprE)
CJK: jk2049
CUR: cu1956
CUA: CU7111_1878(dprE1)
CPL: Cp3995_0106(dprE1)
CPG: Cp316_0116(dprE1)
CPP: CpP54B96_0109(dprE1)
CPK: Cp1002_0102(dprE1)
CPQ: CpC231_0103(dprE1)
CPX: CpI19_0104(dprE1)
CPZ: CpPAT10_0102(dprE1)
COR: Cp267_0113(dprE1)
COP: Cp31_0117(dprE1)
COD: Cp106_0105(dprE1)
COS: Cp4202_0102(dprE1)
COI: CpCIP5297_0113(dprE1)
COE: Cp258_0116(dprE1)
COU: Cp162_0109(dprE1)
CPSE: CPTA_00631
CPSU: CPTB_00902
CPSF: CPTC_00564
CRD: CRES_2120(dprE1)
CUL: CULC22_00149(dprE1)
CUC: CULC809_00151(dprE1)
CUN: Cul210932_0152(dprE1)
CUS: CulFRC11_0147(dprE1)
CUQ: Cul210931_0146(dprE1)
CUZ: Cul05146_0152(dprE1)
CUJ: CUL131002_0136c(dprE1)
CVA: CVAR_2925(dprE1)
CTER: A606_00560
COA: DR71_1174
CSX: CSING_00475(dprE1)
CMQ: B840_00775(dprE1)
CKU: UL82_00355(dprE1)
CCJ: UL81_00550(dprE1)
CMV: CMUST_00580(dprE1)
CEI: CEPID_00985(dprE1)
CTED: CTEST_00730(dprE1)
CUT: CUTER_00440(dprE1)
CDX: CDES_01095(dprE1)
CSP: WM42_1261
CPHO: CPHO_00620
CGV: CGLAU_00465(dprE1)
CAQU: CAQU_00425
CAMG: CAMM_01050
CMIN: NCTC10288_02445(dprE1)
NFA: NFA_1970
NFR: ERS450000_04041(dprE1_2)
RER: RER_02350
ROP: ROP_39530
REQ: REQ_02330
RHB: NY08_3926
RFA: A3L23_02042(dprE1_1)
RHS: A3Q41_01321(dprE1_2)
RHU: A3Q40_03629(dprE1_2)
RRT: 4535765_00240(dprE1_1)
GBR: Gbro_0252
GOR: KTR9_0243
TPR: Tpau_4119
SRT: Srot_2816
SCO: SCO4842(SC5G8.10c)
SGR: SGR_2699
SGB: WQO_22065
SFA: Sfla_2401
SVE: SVEN_4517
SDV: BN159_3566(dprE1)
SALB: XNR_3918
SALS: SLNWT_4766
STRP: F750_4397
SFI: SFUL_4635
SLE: sle_28320(sle_28320)
STRD: NI25_14735
SLAU: SLA_4701
SFK: KY5_4944c
MPH: MLP_13380
MGG: MPLG2_2494(dprE)
TFU: Tfu_2461
NDA: Ndas_0270
NAL: B005_3138
MMAR: MODMU_4725
KRA: Krad_4160
AMD: AMED_0230
AMN: RAM_01165
AMM: AMES_0225
AMZ: B737_0226
AOI: AORI_0235
AJA: AJAP_01220(dprE1)
PDX: Psed_0195
PSEA: WY02_17165
PSEE: FRP1_25600
PSEH: XF36_24965
ALL: CRK60917
CAI: Caci_5664
TBI: Tbis_0812
AFO: Afer_1740
PMT: PMT_2035
 » show all
Taxonomy
Reference
1  [PMID:22069462]
  Authors
Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, Chiarelli LR, Mori G, Kim J, Contreras-Dominguez M, Park YS, Han SJ, Brodin P, Valentini G, Rizzi M, Riccardi G, Pasca MR
  Title
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis.
  Journal
PLoS One 6:e26675 (2011)
DOI:10.1371/journal.pone.0026675
  Sequence
Reference
2  [PMID:22188377]
  Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
  Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
  Journal
J Am Chem Soc 134:912-5 (2012)
DOI:10.1021/ja211042r
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.98.3
IUBMB Enzyme Nomenclature: 1.1.98.3
ExPASy - ENZYME nomenclature database: 1.1.98.3
BRENDA, the Enzyme Database: 1.1.98.3

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