KEGG   ENZYME: 1.1.99.18Help
Entry
EC 1.1.99.18                Enzyme                                 

Name
cellobiose dehydrogenase (acceptor);
cellobiose dehydrogenase;
cellobiose oxidoreductase;
Phanerochaete chrysosporium cellobiose oxidoreductase;
CBOR;
cellobiose oxidase;
cellobiose:oxygen 1-oxidoreductase;
CDH;
cellobiose:(acceptor) 1-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
cellobiose:acceptor 1-oxidoreductase
Reaction(IUBMB)
cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor [RN:R01443 R06246]
Reaction(KEGG)
R01443 R06246(G) > R01442 R06244(G);
(other) R02365 R06247(G)
Show
Substrate
cellobiose [CPD:C00185];
acceptor [CPD:C00028]
Product
cellobiono-1,5-lactone [CPD:C01093];
reduced acceptor [CPD:C00030]
Comment
Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose. The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group. It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones, and molecular oxygen, and one-electron oxidants, including semiquinone species, iron(II) complexes, and the model acceptor cytochrome c [9]. 2,6-Dichloroindophenol can act as acceptor in vitro.
History
EC 1.1.99.18 created 1983, modified 2002 (EC 1.1.5.1 created 1983, incorporated 2002, EC 1.1.3.25 created 1986, incorporated 2005)
Orthology
K19069  cellobiose dehydrogenase (acceptor)
Genes
NCR: NCU00206(cdh-1) NCU05923(cdh-2)
NTE: NEUTE1DRAFT129729(NEUTE1DRAFT_129729) NEUTE1DRAFT50117(NEUTE1DRAFT_50117)
SMP: SMAC_02223 SMAC_06953 SMAC_08924
PAN: PODANSg2565 PODANSg3842 PODANSg4789 PODANSg891
TTT: THITE_123924 THITE_158792 THITE_59724
MTM: MYCTH_111388(cbdA) MYCTH_58125 MYCTH_81925
CTHR: CTHT_0020370 CTHT_0022390
MGR: MGG_07569 MGG_08487 MGG_09189 MGG_11036 MGG_13809
TMN: UCRPA7_2781 UCRPA7_378
SSCK: SPSK_01587 SPSK_04896 SPSK_07893
MAW: MAC_02953
MAJ: MAA_07725
CMT: CCM_06091
ANI: AN7230.2
ANG: ANI_1_168174(An10g00390) ANI_1_2878024(An02g09270)
ZTR: MYCGRDRAFT_62587(CDH)
ABP: AGABI1DRAFT107890(AGABI1DRAFT_107890)
ABV: AGABI2DRAFT188178(AGABI2DRAFT_188178)
 » show all
Taxonomy
Reference
1  [PMID:7103940]
  Authors
Coudray MR, Canevascini G, Meier H.
  Title
Characterization of a cellobiose dehydrogenase in the cellulolytic fungus Sporotrichum (Chrysosporium) thermophile.
  Journal
Biochem J 203:277-84 (1982)
Reference
2
  Authors
Dekker, R.F.H.
  Title
Induction and characterization of a cellobiose dehydrogenase produced by a species of Monilia.
  Journal
J Gen Microbiol 120:309-316 (1980)
Reference
3
  Authors
Dekker, R.F.H.
  Title
Cellobiose dehydrogenase produced by Monilia sp.
  Journal
Methods Enzymol 160:454-463 (1988)
Reference
4  [PMID:8392950]
  Authors
Habu N, Samejima M, Dean JF, Eriksson KE.
  Title
Release of the FAD domain from cellobiose oxidase by proteases from cellulolytic cultures of Phanerochaete chrysosporium.
  Journal
FEBS Lett 327:161-4 (1993)
DOI:10.1016/0014-5793(93)80162-N
Reference
5  [PMID:11282631]
  Authors
Baminger U, Subramaniam SS, Renganathan V, Haltrich D.
  Title
Purification and characterization of cellobiose dehydrogenase from the plant pathogen Sclerotium (Athelia) rolfsii.
  Journal
Appl Environ Microbiol 67:1766-74 (2001)
DOI:10.1128/AEM.67.4.1766-1774.2001
Reference
6  [PMID:11786022]
  Authors
Hallberg BM, Henriksson G, Pettersson G, Divne C.
  Title
Crystal structure of the flavoprotein domain of the extracellular flavocytochrome cellobiose dehydrogenase.
  Journal
J Mol Biol 315:421-34 (2002)
DOI:10.1006/jmbi.2001.5246
Reference
7  [PMID:710416]
  Authors
Ayers AR, Ayers SB, Eriksson KE.
  Title
Cellobiose oxidase, purification and partial characterization of a hemoprotein from Sporotrichum pulverulentum.
  Journal
Eur J Biochem 90:171-81 (1978)
DOI:10.1111/j.1432-1033.1978.tb12588.x
Reference
8  [PMID:7144569]
  Authors
Ayers AR, Eriksson KE.
  Title
Cellobiose oxidase from Sporotrichum pulverulentum.
  Journal
Methods Enzymol 89 Pt D:129-35 (1982)
Reference
9  [PMID:12686420]
  Authors
Mason MG, Nicholls P, Divne C, Hallberg BM, Henriksson G, Wilson MT.
  Title
The heme domain of cellobiose oxidoreductase: a one-electron reducing system.
  Journal
Biochim Biophys Acta 1604:47-54 (2003)
DOI:10.1016/S0005-2728(03)00023-9
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.18
IUBMB Enzyme Nomenclature: 1.1.99.18
ExPASy - ENZYME nomenclature database: 1.1.99.18
BRENDA, the Enzyme Database: 1.1.99.18
CAS: 54576-85-1

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