KEGG   ENZYME: 1.1.99.3Help
Entry
EC 1.1.99.3                 Enzyme                                 

Name
gluconate 2-dehydrogenase (acceptor);
gluconate oxidase;
gluconate dehydrogenase;
gluconic dehydrogenase;
D-gluconate dehydrogenase;
gluconic acid dehydrogenase;
2-ketogluconate reductase;
D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding;
D-gluconate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
D-gluconate:acceptor 2-oxidoreductase
Reaction(IUBMB)
D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor [RN:R01742]
Reaction(KEGG)
Substrate
D-gluconate [CPD:C00257];
acceptor [CPD:C00028]
Product
2-dehydro-D-gluconate [CPD:C06473];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FAD).
History
EC 1.1.99.3 created 1961, modified 1976, modified 1989
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K06151  gluconate 2-dehydrogenase alpha chain
K06152  gluconate 2-dehydrogenase gamma chain
Genes
KPN: KPN_02083 KPN_02084
KPU: KP1_3158 KP1_3160
KPM: KPHS_30620 KPHS_30630
KPP: A79E_2171 A79E_2172
KPH: KPNIH24_13120 KPNIH24_13125
KPZ: KPNIH27_14670 KPNIH27_14675
KPV: KPNIH29_15315 KPNIH29_15320
KPW: KPNIH30_15600 KPNIH30_15605
KPY: KPNIH31_14455 KPNIH31_14460
KPG: KPNIH32_15495 KPNIH32_15500
PPUN: PP4_27720(gadB) PP4_27730
ACX: Achr_f930(gadh1) Achr_f940(gadh3)
SWD: Swoo_3000
SPSW: Sps_04467
TBN: TBH_C2329
MXA: MXAN_1341
ART: Arth_1924
OTE: Oter_2178
GBA: J421_0338
PSAC: PSM36_0071
HTU: Htur_1314
 » show all
Taxonomy
Reference
1  [PMID:6815420]
  Authors
Matsushita K, Shinagawa E, Ameyama M.
  Title
D-Gluconate dehydrogenase from bacteria, 2-keto-D-gluconate-yielding, membrane-bound.
  Journal
Methods Enzymol 89 Pt D:187-93 (1982)
Reference
2  [PMID:13239635]
  Authors
RAMAKRISHNAN T, CAMPBELL JJ.
  Title
Gluconic dehydrogenase of Pseudomonas aeruginosa.
  Journal
Biochim Biophys Acta 17:122-7 (1955)
DOI:10.1016/0006-3002(55)90326-7
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.3
IUBMB Enzyme Nomenclature: 1.1.99.3
ExPASy - ENZYME nomenclature database: 1.1.99.3
BRENDA, the Enzyme Database: 1.1.99.3
CAS: 9028-81-3

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