KEGG   ENZYME: 1.1.99.39Help
Entry
EC 1.1.99.39                Enzyme                                 

Name
D-2-hydroxyglutarate dehydrogenase;
D2HGDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R10575]
Reaction(KEGG)
Substrate
(R)-2-hydroxyglutarate [CPD:C01087];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
Comment
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.
History
EC 1.1.99.39 created 2013
Orthology
K18204  D-2-hydroxyglutarate dehydrogenase
Genes
HSA: 728294(D2HGDH)
PTR: 748707(D2HGDH)
PPS: 100983509(D2HGDH)
GGO: 101133731(D2HGDH)
PON: 100441178(D2HGDH)
NLE: 100598101(D2HGDH)
MCC: 702028(D2HGDH)
MCF: 102118732(D2HGDH)
CSAB: 103218250(D2HGDH)
RRO: 104673075(D2HGDH)
RBB: 108528714(D2HGDH)
CJC: 100398724(D2HGDH)
SBQ: 101043256(D2HGDH)
MMU: 98314(D2hgdh)
RNO: 301624(D2hgdh)
CGE: 100773592(D2hgdh)
NGI: 103730854(D2hgdh)
HGL: 101721825(D2hgdh)
CCAN: 109682469(D2hgdh)
OCU: 100343021(D2HGDH)
TUP: 102498469(D2HGDH)
CFA: 609641(D2HGDH)
AML: 100479601(D2HGDH)
UMR: 103662596(D2HGDH)
ORO: 101366055(D2HGDH)
FCA: 101098076(D2HGDH)
PTG: 102957898(D2HGDH)
AJU: 106984596(D2HGDH)
BTA: 533003(D2HGDH)
BOM: 102270610(D2HGDH)
BIU: 109556611(D2HGDH)
PHD: 102323421(D2HGDH)
CHX: 102191395(D2HGDH) 108633807
OAS: 101121480(D2HGDH)
SSC: 106508365(D2HGDH)
CFR: 102518026(D2HGDH)
CDK: 105096195(D2HGDH)
BACU: 103015223(D2HGDH)
LVE: 103086049(D2HGDH)
OOR: 101284861(D2HGDH)
ECB: 100067872(D2HGDH)
EPZ: 103560352(D2HGDH)
EAI: 106844914(D2HGDH)
MYB: 102261514(D2HGDH)
MYD: 102768727(D2HGDH)
HAI: 109374862(D2HGDH)
RSS: 109439203(D2HGDH)
PALE: 102878813(D2HGDH)
LAV: 100665076(D2HGDH)
TMU: 101351799
MDO: 100012430(D2HGDH)
SHR: 100930000(D2HGDH)
OAA: 100082378(D2HGDH)
GGA: 424853(D2HGDH)
MGP: 100542797(D2HGDH)
CJO: 107317964(D2HGDH)
APLA: 101797675(D2HGDH)
ACYG: 106039274(D2HGDH)
TGU: 100218606(D2HGDH)
GFR: 102043646(D2HGDH)
FAB: 101812765(D2HGDH)
PHI: 102103390(D2HGDH)
PMAJ: 107208912(D2HGDH)
CCAE: 111933731(D2HGDH)
CCW: 104696747(D2HGDH)
FCH: 102048188(ING5)
CLV: 102096725(D2HGDH)
EGZ: 104131328(D2HGDH)
AAM: 106492631(D2HGDH)
ASN: 102385710(ING5)
AMJ: 102572947(D2HGDH)
PSS: 102462295(D2HGDH)
CMY: 102934724(D2HGDH)
CPIC: 101949760(D2HGDH)
ACS: 100553833(d2hgdh)
PVT: 110075295(D2HGDH)
PBI: 103060731(D2HGDH)
GJA: 107114547(D2HGDH)
XLA: 108718159(d2hgdh.S)
XTR: 100379761(d2hgdh)
NPR: 108793034(D2HGDH)
DRE: 565889(d2hgdh)
SRX: 107749221
SANH: 107678686
SGH: 107602612
CCAR: 109054201(d2hgdh)
IPU: 108267866(d2hgdh)
AMEX: 103041769(d2hgdh)
TRU: 101062526(d2hgdh)
LCO: 104926586(d2hgdh)
NCC: 104965960(d2hgdh)
MZE: 101466758(d2hgdh)
OLA: 101158736(d2hgdh)
XMA: 102225785(d2hgdh)
PRET: 103458471(d2hgdh)
NFU: 107392116(d2hgdh)
KMR: 108235694(d2hgdh)
CSEM: 103380089(d2hgdh)
LCF: 108874997(d2hgdh)
SDU: 111225383(d2hgdh)
HCQ: 109517366(d2hgdh)
BPEC: 110155086(d2hgdh)
MALB: 109968014(d2hgdh)
OTW: 112239061
ELS: 105019987(d2hgdh)
SFM: 108936634(d2hgdh)
LCM: 102352928(D2HGDH)
CMK: 103174498(d2hgdh)
CIN: 100177536
SPU: 578006
APLC: 110978983
SKO: 100367659
DME: Dmel_CG3835(D2hgdh)
DER: 6555624
DPE: 6596890
DSI: Dsimw501_GD16587(Dsim_GD16587)
DWI: 6648673
MDE: 101898784
AAG: 5567262
AME: 726115
BIM: 100746986
BTER: 100651710
SOC: 105199825
AEC: 105147989
ACEP: 105623515
HST: 105190242
DQU: 106747688
CFO: 105250685
LHU: 105679351
PGC: 109859645
PCF: 106788573
NVI: 100115941
MDL: 103575679
BMOR: 101739171
PMAC: 106714808
PRAP: 111002266
HAW: 110384058
PXY: 105388680
CLEC: 106663085
ZNE: 110838308
TUT: 107366252
CEL: CELE_F54D5.12(F54D5.12)
CBR: CBG02865
MYI: 110450560
OBI: 106880187
LAK: 106163454
EPA: 110246175
ADF: 107357723
HMG: 100197520
AQU: 100642132
ATH: AT4G36400(D2HGDH)
CRB: 17880136
BRP: 103862468
BOE: 106301382
THJ: 104807474
CPAP: 110822331
CIT: 102622615
TCC: 18610845
GRA: 105776901
EGR: 104419693
GMX: 100811898
VRA: 106777951
VAR: 108334624
CCAJ: 109800121
CAM: 101489255
LJA: Lj2g3v1728750.1(Lj2g3v1728750.1)
AIP: 107642924
LANG: 109331964
FVE: 101309000
PPER: 18771746
PMUM: 103340152
PAVI: 110773625
ZJU: 107424558
CSV: 101216583
CMO: 103493219
MCHA: 111008299
CMAX: 111483383
CMOS: 111436053
CPEP: 111809927
RCU: 8279120
JCU: 105634606
HBR: 110639579
POP: 7480149
JRE: 108992030
VVI: 100253926
SLY: 101247582
SPEN: 107008794
SOT: 102597625
CANN: 107858548
NSY: 104240537
NTO: 104084861
INI: 109172711
SIND: 105165749
OEU: 111401940
HAN: 110867933
LSV: 111913333
CCAV: 112509609
DCR: 108223736
BVG: 104895090
SOE: 110798890
NNU: 104610558
OSA: 4342598
DOSA: Os07t0187200-01(Os07g0187200)
OBR: 102708729
BDI: 100825375
ATS: 109763602(LOC109763602)
SBI: 110432907
ZMA: 100273608(si618066c08)
SITA: 101752911
PDA: 103717795
EGU: 105053375
MUS: 103981967
DCT: 110103843
PEQ: 110029259
ATR: 18429284
PPP: 112278127
MNG: MNEG_7161
APRO: F751_2783
DFA: DFA_11683
SMIN: v1.2.004695.t1(symbB.v1.2.004695.t1)
PTI: PHATRDRAFT_20192(D-LCR)
TCR: 504151.60
 » show all
Taxonomy
Reference
1  [PMID:19586914]
  Authors
Engqvist M, Drincovich MF, Flugge UI, Maurino VG
  Title
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways.
  Journal
J Biol Chem 284:25026-37 (2009)
DOI:10.1074/jbc.M109.021253
  Sequence
[ath:AT4G36400]
Reference
2  [PMID:15070399]
  Authors
Achouri Y, Noel G, Vertommen D, Rider MH, Veiga-Da-Cunha M, Van Schaftingen E
  Title
Identification of a dehydrogenase acting on D-2-hydroxyglutarate.
  Journal
Biochem J 381:35-42 (2004)
DOI:10.1042/BJ20031933
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.39
IUBMB Enzyme Nomenclature: 1.1.99.39
ExPASy - ENZYME nomenclature database: 1.1.99.39
BRENDA, the Enzyme Database: 1.1.99.39

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