KEGG   ENZYME: 1.10.3.11Help
Entry
EC 1.10.3.11                Enzyme                                 

Name
ubiquinol oxidase (non-electrogenic);
plant alternative oxidase;
cyanide-insensitive oxidase;
AOX (gene name);
ubiquinol oxidase;
ubiquinol:O2 oxidoreductase (non-electrogenic)
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
ubiquinol:oxygen oxidoreductase (non-electrogenic)
Reaction(IUBMB)
2 ubiquinol + O2 = 2 ubiquinone + 2 H2O [RN:R09504]
Reaction(KEGG)
Substrate
ubiquinol [CPD:C00390];
O2 [CPD:C00007]
Product
ubiquinone [CPD:C00399];
H2O [CPD:C00001]
Comment
The enzyme, described from the mitochondria of plants and some fungi and protists, is an alternative terminal oxidase that is not sensitive to cyanide inhibition and does not generate a proton motive force. Unlike the electrogenic terminal oxidases that contain hemes (cf. EC 1.10.3.10 and EC 1.10.3.14), this enzyme contains a dinuclear non-heme iron complex. The function of this oxidase is believed to be dissipating excess reducing power, minimizing oxidative stress, and optimizing photosynthesis in response to changing conditions.
History
EC 1.10.3.11 created 2011, modified 2014
Orthology
K17893  ubiquinol oxidase
Genes
RSS: 109442484
ATH: AT1G32350(AOX1D) AT3G22360(AOX1B) AT3G22370(AOX1A) AT3G27620(AOX1C) AT4G22260(IM) AT5G64210(AOX2)
ALY: ARALYDRAFT_313807 ARALYDRAFT_342380 ARALYDRAFT_347138 ARALYDRAFT_479749 ARALYDRAFT_492640 ARALYDRAFT_496620 ARALYDRAFT_655589
CRB: 111828553 17875368 17880621 17886519 17891810 17898298
CSAT: 104710604 104718090 104722813 104731285 104741834 104742221 104746686 104746687 104757604 104762574 104766131 104766133 104777266 104780006 104787386 104787393 104790417
EUS: EUTSA_v10005697mg EUTSA_v10009342mg EUTSA_v10021013mg EUTSA_v10021719mg EUTSA_v10022022mg EUTSA_v10025624mg
BRP: 103834617 103837518 103859909 103859953 103869089(AOX) 103874740
BNA: 106352817 106352956 106356141 106364130 106364143 106366938 106373525 106376504 106376508 106378842 106380619 106388251 106429567 106433618 106437635 106439632
BOE: 106292816 106298984 106317810 106323943 106328733 106343297
THJ: 104809077 104812984 104814432 104819331 104822275
GMX: 100807967 100813378(PTOX) 547897(AOX2) 547924(AOX1) 548077(AOX3)
LJA: Lj2g3v1549830.1(Lj2g3v1549830.1) Lj4g3v0341090.1(Lj4g3v0341090.1) Lj4g3v0341100.1(Lj4g3v0341100.1) Lj4g3v0486230.1(Lj4g3v0486230.1) Lj6g3v1787880.1(Lj6g3v1787880.1)
VVI: 100233056(AOX2) 100247765(Aox1d) 100252878(Aox1a) 100258527
DOSA: Os02t0318100-00(Os02g0318100) Os02t0700400-01(Os02g0700400) Os03t0847500-01(Os03g0847500) Os04t0600200-01(Os04g0600200) Os04t0600300-01(Os04g0600300) Os04t0668900-01(Os04g0668900)
ATS: 109739648(LOC109739648) 109747192(LOC109747192) 109753365(LOC109753365) 109755905(LOC109755905) 109756954(LOC109756954) 109782933(LOC109782933) 109786050(LOC109786050)
APRO: F751_1604
DDI: DDB_G0280819(aoxA)
DFA: DFA_05792(aoxA) DFA_05796
SMIN: v1.2.019638.t1(symbB.v1.2.019638.t1)
VFI: VF_0578(aox)
PIN: Ping_3395
LLO: LLO_1385
MEC: Q7C_1740
TKM: TK90_1660
TVR: TVD_03900
TBD: Tbd_1930
MEH: M301_2656
CSE: Cseg_3042
PZU: PHZ_c3018
RDE: RD1_3047(aox)
NAR: Saro_1576
SGI: SGRAN_1792(aox)
SWI: Swit_5295
STAX: MC45_00170
SSAN: NX02_07005
BLAS: BSY18_2403
 » show all
Taxonomy
Reference
1  [PMID:16657603]
  Authors
Bendall DS, Bonner WD
  Title
Cyanide-insensitive Respiration in Plant Mitochondria.
  Journal
Plant Physiol 47:236-45 (1971)
Reference
2  [PMID:7698344]
  Authors
Siedow JN, Umbach AL, Moore AL
  Title
The active site of the cyanide-resistant oxidase from plant mitochondria contains a binuclear iron center.
  Journal
FEBS Lett 362:10-4 (1995)
DOI:10.1016/0014-5793(95)00196-G
  Sequence
[ath:AT3G22370] [gmx:547924]
Reference
3  [PMID:11106766]
  Authors
Berthold DA, Andersson ME, Nordlund P
  Title
New insight into the structure and function of the alternative oxidase.
  Journal
Biochim Biophys Acta 1460:241-54 (2000)
DOI:10.1016/S0005-2728(00)00149-3
Reference
4  [PMID:20169184]
  Authors
Williams BA, Elliot C, Burri L, Kido Y, Kita K, Moore AL, Keeling PJ
  Title
A broad distribution of the alternative oxidase in microsporidian parasites.
  Journal
PLoS Pathog 6:e1000761 (2010)
DOI:10.1371/journal.ppat.1000761
  Sequence
Reference
5  [PMID:22848123]
  Authors
Gandin A, Duffes C, Day DA, Cousins AB
  Title
The absence of alternative oxidase AOX1A results in altered response of photosynthetic carbon assimilation to increasing CO(2) in Arabidopsis thaliana.
  Journal
Plant Cell Physiol 53:1627-37 (2012)
DOI:10.1093/pcp/pcs107
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.11
IUBMB Enzyme Nomenclature: 1.10.3.11
ExPASy - ENZYME nomenclature database: 1.10.3.11
BRENDA, the Enzyme Database: 1.10.3.11

DBGET integrated database retrieval system