KEGG   ENZYME: 1.10.3.12Help
Entry
EC 1.10.3.12                Enzyme                                 

Name
menaquinol oxidase (H+-transporting);
cytochrome aa3-600 oxidase;
cytochrome bd oxidase;
menaquinol:O2 oxidoreductase (H+-transporting)
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
menaquinol:oxygen oxidoreductase (H+-transporting)
Reaction(IUBMB)
2 menaquinol + O2 = 2 menaquinone + 2 H2O [RN:R09492]
Reaction(KEGG)
Substrate
menaquinol [CPD:C05819];
O2 [CPD:C00007]
Product
menaquinone [CPD:C00828];
H2O [CPD:C00001]
Comment
Cytochrome aa3-600, one of the principal respiratory oxidases from Bacillus subtilis, is a member of the heme-copper superfamily of oxygen reductases, and is a close homologue of the cytochrome bo3 ubiquinol oxidase from Escherichia coli, but uses menaquinol instead of ubiquinol as a substrate.The enzyme also pumps protons across the membrane bilayer, generating a proton motive force.
History
EC 1.10.3.12 created 2011
Orthology
K02826  cytochrome aa3-600 menaquinol oxidase subunit II
K02827  cytochrome aa3-600 menaquinol oxidase subunit I
K02828  cytochrome aa3-600 menaquinol oxidase subunit III
K02829  cytochrome aa3-600 menaquinol oxidase subunit IV
Genes
RSP: RSP_3098(qoxB)
RSH: Rsph17029_3825
RSQ: Rsph17025_3668
BSU: BSU38140(qoxD) BSU38150(qoxC) BSU38160(qoxB) BSU38170(qoxA)
BSR: I33_3965(qoxD) I33_3966(qoxC) I33_3967(qoxB) I33_3968(qoxA)
BSL: A7A1_2114 A7A1_2115 A7A1_2116 A7A1_2117
BSH: BSU6051_38140(qoxD) BSU6051_38150(qoxC) BSU6051_38160(qoxB) BSU6051_38170(qoxA)
BSY: I653_18705 I653_18710 I653_18715 I653_18720
BSUT: BSUB_04050(qoxD) BSUB_04051(qoxC) BSUB_04052(qoxB) BSUB_04053(qoxA)
BSUL: BSUA_04050(qoxD) BSUA_04051(qoxC) BSUA_04052(qoxB) BSUA_04053(qoxA)
BSS: BSUW23_18860(qoxD) BSUW23_18865(qoxC) BSUW23_18870(qoxB) BSUW23_18875(qoxA)
BST: GYO_4206(qoxD) GYO_4207(qoxC) GYO_4208(qoxB) GYO_4209(qoxA)
BSO: BSNT_10473(qoxD) BSNT_10474(qoxC) BSNT_10475(qoxB) BSNT_10476(qoxA)
BSQ: B657_38140(qoxD) B657_38150(qoxC) B657_38160(qoxB) B657_38170(qoxA)
BSX: C663_3720(qoxD) C663_3721(qoxC) C663_3722(qoxB) C663_3723(qoxA)
BLI: BL03871(qoxA) BL03872(qoxB) BL03873(qoxC) BL03874(qoxD)
BLD: BLi04037(qoxD) BLi04038(qoxC) BLi04039(qoxB) BLi04040(qoxA)
BLH: BaLi_c40510(qoxD) BaLi_c40520(qoxC) BaLi_c40530(qoxB) BaLi_c40540(qoxA)
BAY: RBAM_035400(qoxD) RBAM_035410(qoxC) RBAM_035420(qoxB) RBAM_035430(qoxA)
BAQ: BACAU_3562(qoxD) BACAU_3563(qoxC) BACAU_3564(qoxB) BACAU_3565(qoxA)
BYA: BANAU_3719(qoxD) BANAU_3720(qoxC) BANAU_3721(qoxB) BANAU_3722(qoxA)
BAML: BAM5036_3460(qoxD) BAM5036_3461(qoxC) BAM5036_3462(qoxB) BAM5036_3463(qoxA)
BAMA: RBAU_3671(qoxD) RBAU_3672(qoxC) RBAU_3673(qoxB) RBAU_3674(qoxA)
BAMN: BASU_3447(qoxD) BASU_3448(qoxC) BASU_3449(qoxB) BASU_3450(qoxA)
BAMB: BAPNAU_3734(qoxD) BAPNAU_3735(qoxC) BAPNAU_3736(qoxB) BAPNAU_3737(qoxA)
BAMY: V529_38100(qoxD) V529_38110(qoxC) V529_38120(qoxB) V529_38130(qoxA)
BMP: NG74_03712(qoxD) NG74_03713(qoxC) NG74_03714(qoxB) NG74_03715(qoxA)
BAO: BAMF_3650(qoxD) BAMF_3651(qoxC) BAMF_3652(qoxB) BAMF_3653(qoxA)
BQL: LL3_03962(qoxD) LL3_03963(qoxC) LL3_03964(qoxB) LL3_03965(qoxA)
BXH: BAXH7_03956(qoxD) BAXH7_03957(qoxC) BAXH7_03958(qoxB) BAXH7_03959(qoxA)
BQY: MUS_4201(qoxD) MUS_4202(qoxC) MUS_4203(qoxB) MUS_4204(qoxA)
BHA: BH2064(qoxA) BH2065(qoxB) BH2066(qoxC) BH2067(qoxD)
BAN: BA_0700(qoxD) BA_0701(qoxC) BA_0702(qoxB) BA_0703(qoxA)
BAR: GBAA_0700(qoxD) GBAA_0701(qoxC) GBAA_0702(qoxB) GBAA_0703(qoxA)
BAH: BAMEG_3883(qoxA) BAMEG_3884(qoxB) BAMEG_3885(qoxC) BAMEG_3886(qoxD)
BAI: BAA_0783(qoxD) BAA_0784(qoxC) BAA_0785(qoxB) BAA_0786(qoxA)
BANV: DJ46_5158(qoxD) DJ46_5159(qoxC) DJ46_5160(qoxB) DJ46_5161(qoxA)
BCA: BCE_0769(qoxD) BCE_0770(qoxC) BCE_0771(qoxB) BCE_0772(qoxA)
BCZ: BCE33L0611(qoxD) BCE33L0612(qoxC) BCE33L0613(qoxB) BCE33L0614(qoxA)
BCU: BCAH820_0755(qoxD) BCAH820_0756(qoxC) BCAH820_0757(qoxB) BCAH820_0758(qoxA)
BCQ: BCQ_0769(qoxD) BCQ_0770(qoxC) BCQ_0771(qoxB) BCQ_0772(qoxA)
BCX: BCA_0738(qoxD) BCA_0739(qoxC) BCA_0740(qoxB) BCA_0741(qoxA)
BAL: BACI_c07080(qoxD) BACI_c07090(qoxC) BACI_c07100(qoxB) BACI_c07110(qoxA)
BTK: BT9727_0610(qoxD) BT9727_0611(qoxC) BT9727_0612(qoxB) BT9727_0613(qoxA)
BTL: BALH_0637(cyoC) BALH_0638(cyoB) BALH_0639(cyoA)
BTB: BMB171_C0612(qoxD) BMB171_C0613(qoxC) BMB171_C0614(qoxB) BMB171_C0615(qoxA)
BTC: CT43_CH0677(qoxD) CT43_CH0678(qoxC) CT43_CH0679(qoxB) CT43_CH0680(qoxA)
BTG: BTB_c07710 BTB_c07720(qoxC) BTB_c07730(qoxB) BTB_c07740(qoxA)
BTW: BF38_1945(qoxD) BF38_1946(qoxC) BF38_1947(qoxB) BF38_1948(qoxA)
BWW: bwei_4892(qoxA) bwei_4893(qoxB) bwei_4894(qoxC) bwei_4895(qoxD)
BMYO: BG05_5221(qoxA) BG05_5222(qoxB) BG05_5223(qoxC) BG05_5224(qoxD)
BMYC: DJ92_3290(qoxD) DJ92_3291(qoxC) DJ92_3292(qoxB) DJ92_3293(qoxA)
BCL: ABC2134(qoxD) ABC2135(qoxC) ABC2136(qoxB) ABC2137(qoxA)
BMQ: BMQ_1867(cyoA) BMQ_1868(cyoB) BMQ_3127(qoxD) BMQ_3128(qoxC) BMQ_3129(qoxB) BMQ_3130(qoxA)
BMD: BMD_1861(cyoA) BMD_1862(cyoB) BMD_3153(qoxD) BMD_3154(qoxC) BMD_3155(qoxB) BMD_3156(qoxA)
BMEG: BG04_4201(qoxA) BG04_4202(qoxB) BG04_61(qoxD) BG04_62(qoxC) BG04_63(qoxB) BG04_64(qoxA)
BCK: BCO26_0514(qoxD) BCO26_0515(qoxC) BCO26_0516 BCO26_0517(qoxA)
BCOA: BF29_3026(qoxD) BF29_3027(qoxC) BF29_3028(qoxB) BF29_3029(qoxA)
BACL: BS34A_41320(qoxD) BS34A_41330(qoxC) BS34A_41340(qoxB) BS34A_41350(qoxA)
BGY: BGLY_4435(qoxD) BGLY_4436(qoxC) BGLY_4437(qoxB) BGLY_4438(qoxA)
BKO: CKF48_20945(qoxD) CKF48_20950(qoxC) CKF48_20960(qoxA)
OIH: OB2253(qoxA) OB2254(qoxB) OB2255(qoxC) OB2256
GKA: GK3456(qoxD) GK3457(qoxC) GK3458(qoxB) GK3459(qoxA)
GGH: GHH_c35460(qoxD) GHH_c35470(qoxC) GHH_c35480(qoxB) GHH_c35490(qoxA)
GEA: GARCT_03435(qoxD) GARCT_03436(qoxC) GARCT_03437(qoxB) GARCT_03438(qoxA)
AFL: Aflv_0272(qoxA) Aflv_0273(qoxB) Aflv_0274(qoxC) Aflv_0275(qoxD)
ANM: GFC28_2741(qoxA) GFC28_2742(ctaD) GFC28_2743(qoxC) GFC28_2744(qoxD)
AAMY: GFC30_282(qoxA) GFC30_283(ctaD) GFC30_284(qoxC) GFC30_285(qoxD)
ANL: GFC29_2690(qoxD) GFC29_2691(qoxC) GFC29_2692(ctaD) GFC29_2693(qoxA)
LYB: C3943_11185(qoxD) C3943_11190(qoxC) C3943_11195(qoxB) C3943_11200(qoxA) C3943_16690(qoxA) C3943_16695(qoxB) C3943_16700(qoxC) C3943_16705(qoxD)
HHD: HBHAL_3694(qoxD) HBHAL_3695(qoxC) HBHAL_3696(qoxB) HBHAL_3697(qoxA)
VPN: A21D_01992(qoxA) A21D_01993(qoxB) A21D_01994(qoxC) A21D_01995(qoxD)
SAU: SA0910 SA0911(qoxC) SA0912(qoxB) SA0913
SAV: SAV1058 SAV1059(qoxC) SAV1060(qoxB) SAV1061
SAM: MW0941 MW0942(qoxC) MW0943(qoxB) MW0944
SAR: SAR1031(qoxD) SAR1032(qoxC) SAR1033(qoxB) SAR1034(qoxA)
SAC: SACOL1067(qoxD) SACOL1068(qoxC) SACOL1069(qoxA) SACOL1070(qoxB)
SAE: NWMN_0927(qoxD) NWMN_0928(qoxC) NWMN_0929(qoxB) NWMN_0930(qoxA)
SAD: SAAV_1022(qoxD) SAAV_1023(qoxC) SAAV_1024(qoxA) SAAV_1025(qoxB)
SUC: ECTR2_913(qoxD) ECTR2_914(qoxC) ECTR2_915(qoxB) ECTR2_916(qoxA)
SUZ: MS7_1015(qoxD) MS7_1016(qoxC) MS7_1017(qoxB) MS7_1018(qoxA)
SUW: SATW20_10540(qoxD) SATW20_10550(qoxC) SATW20_10560(qoxB) SATW20_10570(qoxA)
SUG: SAPIG1055(qoxD) SAPIG1056(qoxC) SAPIG1057(qoxB) SAPIG1058
SAUE: RSAU_000945(qoxD) RSAU_000946(qoxC) RSAU_000947(qoxB) RSAU_000948(qoxA)
SAUS: SA40_0928(qoxD) SA40_0929(qoxC) SA40_0930(qoxB) SA40_0931(qoxA)
SAUU: SA957_0943(qoxD) SA957_0944(qoxC) SA957_0945(qoxB) SA957_0946(qoxA)
SAUG: SA268_0946(qoxD) SA268_0947(qoxC) SA268_0948(qoxB) SA268_0949(qoxA)
SAUZ: SAZ172_0998(qoxD) SAZ172_0999(qoxC) SAZ172_1000(qoxB) SAZ172_1001(qoxA)
SAUF: X998_1057(qoxD) X998_1058(qoxC) X998_1059(qoxB) X998_1060(qoxA)
SAB: SAB0924c(qoxD) SAB0925c(qoxC) SAB0926c(qoxB) SAB0927c(qoxA)
SUY: SA2981_1012(qoxD) SA2981_1013(qoxC) SA2981_1014(qoxB) SA2981_1015(qoxA)
SAUB: C248_1083(qoxD) C248_1084(qoxC) C248_1085(qoxB) C248_1086(qoxA)
SAUC: CA347_974(qoxD) CA347_975(qoxC) CA347_976(qoxB) CA347_977(qoxA)
SAUR: SABB_01024(qoxD) SABB_01025(qoxC) SABB_01026(qoxB) SABB_03392(qoxA)
SER: SERP0643(qoxD) SERP0644(qoxC) SERP0645(qoxA) SERP0646(qoxB)
SEPS: DP17_2089(qoxD) DP17_2090(qoxC) DP17_2091(qoxB) DP17_2092(qoxA)
SHA: SH1901 SH1902(qoxB) SH1903(qoxC) SH1904
SHH: ShL2_01766(qoxA) ShL2_01767(qoxB) ShL2_01768(qoxC) ShL2_01769(qoxD)
SCA: SCA_0678(qoxD) SCA_0679(qoxC) SCA_0680(qoxB) SCA_0681(qoxA)
SLN: SLUG_18100(qoxA) SLUG_18110(qoxB) SLUG_18120(qoxC) SLUG_18130(qoxD)
SDT: SPSE_1735(qoxA) SPSE_1736(qoxB) SPSE_1737(qoxC) SPSE_1738(qoxD)
SXO: SXYL_01875(qoxA) SXYL_01876(qoxB) SXYL_01877(qoxC) SXYL_01878(qoxD)
SHU: SHYC_09015(qoxA) SHYC_09020(qoxB) SHYC_09025(qoxC) SHYC_09030(qoxD)
SCAP: AYP1020_0381(qoxD) AYP1020_0382(qoxC) AYP1020_0383(qoxB) AYP1020_0384(qoxA)
SSIF: AL483_06530(qoxA) AL483_06535(qoxB) AL483_06540(qoxC) AL483_06545(qoxD)
SPET: CEP67_00125(qoxD) CEP67_00130(qoxC) CEP67_00135(qoxB) CEP67_00140(qoxA)
SSCU: CEP64_08245(qoxA) CEP64_08250(qoxB) CEP64_08255(qoxC) CEP64_08260(qoxD)
SKL: C7J89_10415(qoxA) C7J89_10420(qoxB) C7J89_10425(qoxC) C7J89_10430(qoxD)
SFQ: C7J90_07085(qoxD) C7J90_07090(qoxC) C7J90_07095(qoxB) C7J90_07100(qoxA)
LMO: lmo0013(qoxA) lmo0014(qoxB) lmo0015(qoxC) lmo0016(qoxD)
LMN: LM5578_3006(qoxD) LM5578_3007(qoxC) LM5578_3008(qoxB) LM5578_3009(qoxA)
LMY: LM5923_2955(qoxD) LM5923_2956(qoxC) LM5923_2957(qoxB) LM5923_2958(qoxA)
LMOD: LMON_0014(qoxA) LMON_0015(qoxB) LMON_0016(qoxC) LMON_0017(qoxD)
LMOQ: LM6179_0292(qoxA) LM6179_0293(qoxB) LM6179_0294(qoxC) LM6179_0295(qoxD)
LMR: LMR479A_0013(qoxA) LMR479A_0014(qoxB) LMR479A_0015(qoxC) LMR479A_0016(qoxD)
LMC: Lm4b_00016(qoxA) Lm4b_00017(qoxB) Lm4b_00018(qoxC) Lm4b_00019(qoxD)
LMOG: BN389_00170(qoxA) BN389_00180(qoxB) BN389_00190(qoxC) BN389_00200(qoxD)
LMOL: LMOL312_0016(qoxA) LMOL312_0017(qoxB) LMOL312_0018(qoxC) LMOL312_0019(qoxD)
LMOZ: LM1816_03517(qoxA) LM1816_03527(qoxB) LM1816_03532(qoxC) LM1816_03537(qoxD)
LMH: LMHCC_2647(qoxD) LMHCC_2648(qoxC) LMHCC_2649(qoxB) LMHCC_2650
LMQ: LMM7_0014(qoxA) LMM7_0015(qoxB) LMM7_0016(qoxC) LMM7_0017(qoxD)
LML: lmo4a_0013(qoxA) lmo4a_0014(qoxB) lmo4a_0015(qoxC) lmo4a_0016(qoxD)
LWE: lwe0014(qoxA) lwe0015(qoxB) lwe0016(qoxC) lwe0017(qoxD)
LSG: lse_0013(qoxA) lse_0014(qoxB) lse_0015(qoxC) lse_0016(qoxD)
LIV: LIV_0013(qoxA) LIV_0014(qoxB) LIV_0015(qoxC) LIV_0016(qoxD)
BTHS: CNY62_05950(qoxA) CNY62_05955(qoxB) CNY62_05960(qoxC) CNY62_05965(qoxD)
BBE: BBR47_11920(qoxA) BBR47_11930(qoxB) BBR47_51760(cyoB)
PPY: PPE_04072
PPM: PPSC2_21520(cyoB)
PPO: PPM_4288(cyoB)
PPOL: X809_37535
PPQ: PPSQR21_043450(cyoB)
PPOY: RE92_15730
PMS: KNP414_07180(qoxB)
PMW: B2K_34045
PLV: ERIC2_c37910(qoxD) ERIC2_c37920(qoxC) ERIC2_c37930(qoxB) ERIC2_c37940(qoxA)
PRI: PRIO_1135 PRIO_1136(qoxC) PRIO_1137(qoxB) PRIO_1138(qoxA)
PSWU: SY83_17195
PDH: B9T62_37835(qoxD) B9T62_37840(qoxC) B9T62_37845(qoxB) B9T62_37850(qoxA)
ASOC: CB4_00460(qoxB)
AAD: TC41_0626(qoxA) TC41_0627(qoxB) TC41_0628(qoxC) TC41_0629
SOB: CSE16_05230(qoxD) CSE16_05235(qoxC) CSE16_05240(qoxB) CSE16_05245(qoxA) CSE16_15695(qoxD) CSE16_15700(qoxC) CSE16_15705(qoxB) CSE16_15710(qoxA)
KUR: ASO14_794(qoxA) ASO14_795(qoxB) ASO14_796(qoxC) ASO14_797(qoxD)
SAY: TPY_0364(qoxA) TPY_0365(qoxB) TPY_0366(cyoC) TPY_0367
STO: STK_01030(soxM) STK_01050(soxH) STK_01350(soxA) STK_01360(soxB) STK_23960(soxB2)
SSO: SSO2657(soxB) SSO2658(soxA) SSO2969(soxH) SSO2973(soxM)
SAI: Saci_2088 Saci_2089(soxA) Saci_2259(soxH) Saci_2263(soxM)
POG: Pogu_1770(poxC) Pogu_1771(poxB)
 » show all
Taxonomy
Reference
1  [PMID:8388393]
  Authors
Lauraeus M, Wikstrom M
  Title
The terminal quinol oxidases of Bacillus subtilis have different energy conservation properties.
  Journal
J Biol Chem 268:11470-3 (1993)
Reference
2  [PMID:7575098]
  Authors
Lemma E, Simon J, Schagger H, Kroger A
  Title
Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis.
  Journal
Arch Microbiol 163:432-8 (1995)
  Sequence
Reference
3  [PMID:20351111]
  Authors
Yi SM, Narasimhulu KV, Samoilova RI, Gennis RB, Dikanov SA
  Title
Characterization of the semiquinone radical stabilized by the cytochrome aa3-600  menaquinol oxidase of Bacillus subtilis.
  Journal
J Biol Chem 285:18241-51 (2010)
DOI:10.1074/jbc.M110.116186
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.12
IUBMB Enzyme Nomenclature: 1.10.3.12
ExPASy - ENZYME nomenclature database: 1.10.3.12
BRENDA, the Enzyme Database: 1.10.3.12

DBGET integrated database retrieval system