KEGG   ENZYME: 1.11.1.10Help
Entry
EC 1.11.1.10                Enzyme                                 

Name
chloride peroxidase;
chloroperoxidase;
CPO;
vanadium haloperoxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
chloride:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
RH + chloride + H2O2 = RCl + 2 H2O [RN:R00052]
Reaction(KEGG)
Substrate
RH [CPD:C01371];
chloride [CPD:C00698];
H2O2 [CPD:C00027]
Product
RCl [CPD:C01334];
H2O [CPD:C00001]
Comment
Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds. Also oxidizes bromide and iodide. Enzymes of this type are either heme-thiolate proteins, or contain vanadate. A secreted enzyme produced by the ascomycetous fungus Caldariomyces fumago (Leptoxyphium fumago) is an example of the heme-thiolate type. It catalyses the production of hypochlorous acid by transferring one oxygen atom from H2O2 to chloride. At a separate site it catalyses the chlorination of activated aliphatic and aromatic substrates, via HClO and derived chlorine species. In the absence of halides, it shows peroxidase (e.g. phenol oxidation) and peroxygenase activities. The latter inserts oxygen from H2O2 into, for example, styrene (side chain epoxidation) and toluene (benzylic hydroxylation), however, these activities are less pronounced than its activity with halides. Has little activity with non-activated substrates such as aromatic rings, ethers or saturated alkanes. The chlorinating peroxidase produced by ascomycetous fungi (e.g. Curvularia inaequalis) is an example of a vanadium chloroperoxidase, and is related to bromide peroxidase (EC 1.11.1.18). It contains vanadate and oxidizes chloride, bromide and iodide into hypohalous acids. In the absence of halides, it peroxygenates organic sulfides and oxidizes ABTS [2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid)] but no phenols.
History
EC 1.11.1.10 created 1972, modified 2011
Orthology
K00433  non-heme chloroperoxidase
K17990  vanadium chloroperoxidase
Genes
MGR: MGG_02210
PNO: SNOG_09935
BZE: COCCADRAFT_95108
BSC: COCSADRAFT_212376
BOR: COCMIDRAFT_29537
ZTR: MYCGRDRAFT_86416
ENT: Ent638_1149
ENC: ECL_02122
ENO: ECENHK_07930 ECENHK_12485
ECLO: ENC_05700
ECLX: LI66_10185
KPN: KPN_02451
KPU: KP1_3653
KPP: A79E_1656
KPT: VK055_5070(cpo)
KPE: KPK_1737
KPR: KPR_1654(cpo)
KPJ: N559_1810
KPX: PMK1_04893(cpo)
KPNU: LI86_08850
KPNK: BN49_3666(cpo)
KVA: Kvar_1628
KOX: KOX_20890
KOE: A225_3037
EAE: EAE_13185
EAR: CCG31335
CKO: CKO_04375
CRO: ROD_06251
CAMA: F384_02695
EBF: D782_2077
SMAF: D781_2314
RAA: Q7S_10260
EBI: EbC_16970
XCC: XCC2172(cpo)
XCB: XC_1946
XCP: XCR_2441
XCV: XCV2196
XAX: XACM_2141
XAC: XAC2035(cpo)
XCI: XCAW_01789(mhpC)
XPH: XppCFBP6546_01750(XppCFBP6546P_01750)
SML: Smlt2516 Smlt2882(cpo)
SMZ: SMD_2189 SMD_2519(cpo)
LAB: LA76x_0626(cpo) LA76x_2668(cpo)
LCP: LC55x_4524(cpo) LC55x_5604(cpo)
LGU: LG3211_4332(cpo) LG3211_4683(cpo)
LEZ: GLE_0565(cpo)
LEM: LEN_4362
PAE: PA2717(cpo)
PAEV: N297_2799
PAEI: N296_2799
PAU: PA14_29020(cpo)
PAP: PSPA7_3995(cpo)
PAG: PLES_23871(cpo)
PAF: PAM18_2255(cpo)
PNC: NCGM2_3745(cpo)
PAEB: NCGM1900_3778(cpo)
PAEP: PA1S_11995
PAEM: U769_11570
PAEL: T223_12155
PAEU: BN889_07075(cpo)
PAEG: AI22_21900
PAEC: M802_2796
PAEO: M801_2665
PRE: PCA10_34310(est)
PCQ: PcP3B5_31480(cpo)
PPU: PP_4021(cpo)
PPF: Pput_1812
PPT: PPS_3431
PPB: PPUBIRD1_1793(est)
PPI: YSA_08728
PPX: T1E_3283(cpo)
PPUH: B479_17070
PPUT: L483_22515
PPUN: PP4_17320(est)
PPUD: DW66_3878
PMON: X969_16350
PMOT: X970_15995
PSB: Psyr_4478
PFL: PFL_3458(cpo)
PFC: PflA506_3576(cpo)
PFB: VO64_2380
PMAN: OU5_5772(cpo) OU5_5773
PEN: PSEEN2814(cpo) PSEEN5395
PSA: PST_0170
PSZ: PSTAB_0233(fold)
PSTT: CH92_10190
PKC: PKB_3099(cpo) PKB_4370(thcF)
PSEC: CCOS191_2749(cpo)
PSOS: POS17_2475
PSIL: PMA3_18265
ACB: A1S_1833
ABY: ABAYE1730(dch)
ABN: AB57_2170
ABB: ABBFA_001620(cpo)
ABX: ABK1_2401
ABH: M3Q_2284
ABAD: ABD1_18580
ABAZ: P795_7730
ABAU: IX87_20565
ABAA: IX88_11355
ACC: BDGL_001311(cpo)
LLG: 44548918_01170(cpo)
MAH: MEALZ_2527(cpo)
HCH: HCH_03053
CSA: Csal_0764
ADI: B5T_01263
REH: H16_A2213(h16_A2213) H16_B1410(h16_B1410) H16_B1427(h16_B1427) H16_B1943(h16_B1943)
CNC: CNE_1c21170(cpo) CNE_2c02760(thcF) CNE_2c19030(cpo)
RME: Rmet_5312(cpo)
CGD: CR3_3829(cpo)
BPS: BPSS0444(cpo)
BPM: BURPS1710b_A1992(cpo)
BPL: BURPS1106A_A0603(cpoF)
BPSE: BDL_3672(cpo)
BPSM: BBQ_5750(cpo)
BPSU: BBN_3846(cpo)
BPSD: BBX_5509(cpo)
BPZ: BP1026B_II0496(cpo)
BPK: BBK_5651(cpo)
BPSH: DR55_4907(cpo)
BPSA: BBU_5601(cpo)
BPSO: X996_4657(cpo)
BUT: X994_4175
BOK: DM82_4538(cpo)
BOC: BG90_6055
BVE: AK36_5141(cpo) AK36_5807
BCEN: DM39_7115
BCEW: DM40_5024(cpo) DM40_5190(cpo) DM40_5272(cpo)
BMU: Bmul_1700
BMJ: BMULJ_01542(cpo)
BMK: DM80_101
BMUL: NP80_1634
BCED: DM42_6552(cpo) DM42_7217(cpo) DM42_7230(cpo) DM42_7232(cpo)
BDL: AK34_1818(cpo) AK34_5281(cpo) AK34_5563(cpo) AK34_5633
BGU: KS03_5400
BGO: BM43_1184(cpo) BM43_3429(cpo)
BUK: MYA_5744
BXB: DR64_4712(cpo) DR64_5445 DR64_7115(cpo)
PPNO: DA70_12945
PPNM: LV28_17750
PPUL: RO07_11945
PSPU: NA29_07970
PAPI: SG18_12280
PLG: NCTC10937_01286(cpo_1)
AXY: AXYL_00446(cpo)
PUT: PT7_0850
ODI: ODI_R2242
HYB: Q5W_22985
JAG: GJA_5363(cpo)
PBH: AAW51_0512(cpo)
AZO: azo0490
GUR: Gura_3450
DMA: DMR_10710
DBA: Dbac_1162
RHI: NGR_b15830(cpo1) NGR_b15880(cpo2) NGR_c25070
SFD: USDA257_c37250(cpo1) USDA257_c49370(cpo2)
SAME: SAMCFNEI73_Ch2843(cpo)
EAD: OV14_3277 OV14_a1505(cpo1) OV14_b0010(cpo1) OV14_b0638(cpo2) OV14_b1006(cpo1)
ATU: Atu3463(cpoF) Atu3493 Atu4778(cpo) Atu5065(prxC) Atu5389
ARA: Arad_8698
AVI: Avi_5112
REP: IE4803_CH02585(cpo-1) IE4803_CH02681(cpo-2)
REI: IE4771_CH02709(cpo)
RLE: RL2967(cpo1) pRL110136(cpo2) pRL120450(cpO)
RHN: AMJ98_CH02726(cpo-1) AMJ98_PD00149(cpo-2) AMJ98_PE00081(cpo-3)
RPHA: AMC79_CH02702(cpo-1) AMC79_PD00087(cpo-2)
RHX: AMK02_CH02653(cpo-1) AMK02_PD00083(cpo-3) AMK02_PE00147(cpo-2)
RHK: Kim5_CH02714(cpo)
REZ: AMJ99_CH02725(cpo-1) AMJ99_PC00149(cpo-2) AMJ99_PD00081(cpo-3)
BME: BMEI0733
BJA: blr1251
BRO: BRAD285_2101(thcF) BRAD285_4208(cpo)
RPA: RPA2105
OCA: OCAR_6762
OCG: OCA5_c13120(cpoO)
OCO: OCA4_c13120(cpoO)
BTR: BT_1151
XAU: Xaut_1276
MEX: Mext_3628
MCH: Mchl_3920
MPO: Mpop_3910
META: Y590_17915
MSL: Msil_3584
RVA: Rvan_2221
MMED: Mame_02883(cpo)
MCG: GL4_1183
HDI: HDIA_0454(cpo)
CAK: Caul_0299
PZU: PHZ_c2785
HNE: HNE_3365
SPHK: SKP52_02215(cpo1) SKP52_08065(cpo2) SKP52_12265(cpo3)
SPHU: SPPYR_0626(cpo) SPPYR_1090(cpo)
SPHM: G432_05745
STAX: MC45_16820
SPHI: TS85_12370
SJP: SJA_C1-25290(cpo)
BLAS: BSY18_1618
ALB: AEB_P3036
GOY: GLS_c08240(cpo)
GDI: GDI0081(cpo)
KSC: CD178_00313(cpo)
APK: APA386B_1648(cpo)
AZL: AZL_b04970(cpo) AZL_c02950(cpo)
ALI: AZOLI_2360(cpo1) AZOLI_p20590(cpo2)
ABS: AZOBR_p170033(cpo)
TMO: TMO_3352
BSR: I33_1225(yisY)
BSL: A7A1_0906
BSH: BSU6051_10900(yisY)
BSUT: BSUB_01187(yisY)
BSUL: BSUA_01187(yisY)
BSUS: Q433_06160
BSS: BSUW23_05525(yisY)
BST: GYO_1396(yisY)
BSO: BSNT_07537(yisY)
BSQ: B657_10900(yisY)
BSX: C663_1113(yisY)
BLD: BLi02236(yisY)
BLH: BaLi_c23180(yisY)
BAR: GBAA_5030
BAT: BAS4670
BAI: BAA_5042
BANT: A16_50250
BANR: A16R_50920
BANS: BAPAT_4825
BANV: DJ46_3688
BCE: BC4774
BCQ: BCQ_4591
BCX: BCA_4906
BNC: BCN_4690
BCF: bcf_23970
BCER: BCK_11265
BTL: BALH_4349
BTT: HD73_5087
BTHI: BTK_25095
BTG: BTB_c25570(yisY1) BTB_c49340(yisY2)
BTI: BTG_24955
BTW: BF38_537
BWW: bwei_0114
BMYO: BG05_1260
BMH: BMWSH_2662(yisY)
BMEG: BG04_4994
BJS: MY9_1188
BMET: BMMGA3_01055(yisY)
BACY: QF06_04385
BACL: BS34A_12040(yisY)
BALM: BsLM_1135
BGY: BGLY_1317
HHD: HBHAL_2685(yisY)
EAN: Eab7_1456
PPY: PPE_00292
PPM: PPSC2_01700(yisY)
PPO: PPM_0322(yisY)
PPOL: X809_01285
PPOY: RE92_10205
PSAB: PSAB_01280
PSWU: SY83_12330
LLM: llmg_1737(cpo)
SAG: SAG2132
SAN: gbs2091
SAK: SAK_2071
STC: str1257
STL: stu1257
STE: STER_1236
EFA: EF1028
CAE: SMB_G2723(yisY)
CAY: CEA_G2697
CTC: CTC_01150
CBO: CBO0840
CBA: CLB_0880
CBH: CLC_0894
CBY: CLM_0988
CBL: CLK_0246
CBB: CLD_3723
CBF: CLI_0921
CBM: CBF_0892
CKL: CKL_0764
CKR: CKR_0686
CSB: CLSA_c17800(yisY)
CLT: CM240_1284(yisY)
CBV: U729_2988
CSQ: CSCA_0728
CTYK: CTK_C27470
AOE: Clos_1937
CCE: Ccel_2497
CSD: Clst_1672
CCEL: CCDG5_0491
CPY: Cphy_1659
HSD: SD1D_1226(yisY)
DAE: Dtox_1575
SGY: Sgly_3187
TOC: Toce_1661
PUF: UFO1_3565
PFT: JBW_00148
MID: MIP_02895
MIR: OCQ_19440
MMC: Mmcs_1286
MKM: Mkms_1303
MJL: Mjls_1315
MVA: Mvan_1567
MGI: Mflv_3146
MPHL: MPHLCCUG_01913(cpo_1)
MVQ: MYVA_1320
MTHN: 4412656_00681(cpo)
RER: RER_36450
REY: O5Y_16730
ROP: ROP_11130
RHB: NY08_4866
RFA: A3L23_04144(cpo_4)
RHS: A3Q41_04123(cpo_4)
GOR: KTR9_4642
GRU: GCWB2_05230(cpo3)
SCO: SCO0465(SCF76.05c)
SALB: XNR_4009
SGR: SGR_1103
SCB: SCAB_4601(cpo)
SFA: Sfla_0959
SDV: BN159_0372(cpo1) BN159_0863(cpo3)
STRP: F750_5890
SLV: SLIV_35615(cpo)
STRE: GZL_00998
SAMB: SAM23877_7286(cpo)
SMAL: SMALA_4059
MTS: MTES_1614
XCE: Xcel_2040
IDO: I598_2388(cpo_2) I598_2642(cpo_3)
CFI: Celf_2625
TFU: Tfu_1653
NDA: Ndas_2407
TCU: Tcur_0159
SRO: Sros_5197
FAL: FRAAL2804(cpo)
NML: Namu_1046
MMAR: MODMU_3277(cpo)
KRA: Krad_0455
SEN: SACE_3365(cpo)
SESP: BN6_55950(cpo)
ACTI: UA75_15740
ACAD: UA74_15175
SAQ: Sare_4822
CAI: Caci_2084
SYZ: MYO_2810
CALH: IJ00_10370
PNL: PNK_1792
OBG: Verru16b_01112(cpo)
RBA: RB3694
PSL: Psta_0376
PIR: VN12_05260(cpo)
KST: KSMBR1_1244(cpo)
SUS: Acid_3478
ABAC: LuPra_01485(cpo_2)
GAU: GAU_3315
FLN: FLA_3422
MUC: MuYL_1224
SLI: Slin_3914
FAE: FAES_3445
FJO: Fjoh_4179
FJG: BB050_04050(cpo)
CBAL: M667_12540
CBAT: M666_12525
CHZ: CHSO_3369(cpo3)
CCH: Cag_1627
MAC: MA_0993
MHOR: MSHOH_1510
NEV: NTE_02236
 » show all
Taxonomy
Reference
1  [PMID:5949836]
  Authors
Morris DR, Hager LP.
  Title
Chloroperoxidase. I. Isolation and properties of the crystalline glycoprotein.
  Journal
J Biol Chem 241:1763-8 (1966)
Reference
2  [PMID:1056179]
  Authors
Hager LP, Hollenberg PF, Rand-Meir T, Chiang R, Doubek D.
  Title
Chemistry of peroxidase intermediates.
  Journal
Ann N Y Acad Sci 244:80-93 (1975)
DOI:10.1111/j.1749-6632.1975.tb41524.x
Reference
3  [PMID:17777960]
  Authors
Theiler R, Cook JC, Hager LP, Siuda JF
  Title
Halohydrocarbon synthesis by bromoperoxidase.
  Journal
Science 202:1094-6 (1978)
DOI:10.1126/science.202.4372.1094
Reference
4  [PMID:8747463]
  Authors
Sundaramoorthy M, Terner J, Poulos TL
  Title
The crystal structure of chloroperoxidase: a heme peroxidase--cytochrome P450 functional hybrid.
  Journal
Structure 3:1367-77 (1995)
DOI:10.1016/S0969-2126(01)00274-X
Reference
5  [PMID:11670813]
  Authors
ten Brink HB, Tuynman A, Dekker HL, Hemrika W, Izumi Y, Oshiro T, Schoemaker HE, Wever R
  Title
Enantioselective Sulfoxidation Catalyzed by Vanadium Haloperoxidases.
  Journal
Inorg Chem 37:6780-6784 (1998)
DOI:10.1021/ic9806075
Reference
6  [PMID:10885468]
  Authors
ten Brink HB, Dekker HL, Schoemaker HE, Wever R
  Title
Oxidation reactions catalyzed by vanadium chloroperoxidase from Curvularia inaequalis.
  Journal
J Inorg Biochem 80:91-8 (2000)
DOI:10.1016/S0162-0134(00)00044-1
  Sequence
Reference
7  [PMID:16870515]
  Authors
Murali Manoj K
  Title
Chlorinations catalyzed by chloroperoxidase occur via diffusible intermediate(s)  and the reaction components play multiple roles in the overall process.
  Journal
Biochim Biophys Acta 1764:1325-39 (2006)
DOI:10.1016/j.bbapap.2006.05.012
Reference
8  [PMID:16790441]
  Authors
Kuhnel K, Blankenfeldt W, Terner J, Schlichting I
  Title
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate.
  Journal
J Biol Chem 281:23990-8 (2006)
DOI:10.1074/jbc.M603166200
Reference
9  [PMID:18220360]
  Authors
Manoj KM, Hager LP
  Title
Chloroperoxidase, a janus enzyme.
  Journal
Biochemistry 47:2997-3003 (2008)
DOI:10.1021/bi7022656
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.10
IUBMB Enzyme Nomenclature: 1.11.1.10
ExPASy - ENZYME nomenclature database: 1.11.1.10
BRENDA, the Enzyme Database: 1.11.1.10
CAS: 9055-20-3

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