KEGG   ENZYME: 1.11.1.12Help
Entry
EC 1.11.1.12                Enzyme                                 

Name
phospholipid-hydroperoxide glutathione peroxidase;
peroxidation-inhibiting protein;
PHGPX;
peroxidation-inhibiting protein:peroxidase,glutathione (phospholipid hydroperoxide-reducing);
phospholipid hydroperoxide glutathione peroxidase;
hydroperoxide glutathione peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
glutathione:lipid-hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O [RN:R03167]
Reaction(KEGG)
Substrate
glutathione [CPD:C00051];
hydroperoxy-fatty-acyl-[lipid]
Product
glutathione disulfide [CPD:C00127];
hydroxy-fatty-acyl-[lipid];
H2O [CPD:C00001]
Comment
A protein containing a selenocysteine residue. The products of action of EC 1.13.11.12 lipoxygenase on phospholipids can act as acceptors; H2O2 can also act, but much more slowly (cf. EC 1.11.1.9 glutathione peroxidase).
History
EC 1.11.1.12 created 1989, modified 2015
Pathway
ec00480  Glutathione metabolism
Orthology
K05361  phospholipid-hydroperoxide glutathione peroxidase
Genes
HSA: 2879(GPX4)
PTR: 741876(GPX4)
PPS: 100990361(GPX4)
GGO: 101140897(GPX4)
PON: 100458624(GPX4)
NLE: 100601223(GPX4)
MCC: 705333(GPX4)
MCF: 102142580(GPX4)
CSAB: 103233593(GPX4)
RRO: 104671424(GPX4)
RBB: 108537892(GPX4)
CJC: 100391793(GPX4) 103790339
SBQ: 101053315(GPX4)
MMU: 625249(Gpx4)
RNO: 29328(Gpx4)
CGE: 100765235(Gpx4)
NGI: 103737339(Gpx4)
HGL: 101708875(Gpx4)
CCAN: 109681876(Gpx4)
TUP: 102483947(GPX4)
AML: 100464258(GPX4)
UMR: 103681777(GPX4)
ORO: 101377930(GPX4)
FCA: 101095956(GPX4)
PTG: 102949955(GPX4)
AJU: 106978096(GPX4)
BTA: 286809(GPX4)
BOM: 102284111(GPX4)
BIU: 109561977(GPX4)
PHD: 102324249(GPX4)
CHX: 100860867(GPX4)
OAS: 101113149(GPX4)
SSC: 399537(GPX4)
CFR: 102515650(GPX4)
CDK: 105104118(GPX4)
BACU: 103000913(GPX4)
LVE: 103071491(GPX4)
OOR: 101270118(GPX4)
ECB: 102147383(GPX4)
EAI: 106834230(GPX4)
MYB: 102247160 102257806(GPX4)
MYD: 102758267(GPX4)
HAI: 109390605
RSS: 109453931(GPX4)
PALE: 102878189(GPX4)
LAV: 100675152(GPX4)
TMU: 101355012
MDO: 100015749(GPX4)
SHR: 100930158(GPX4)
OAA: 100088643(GPX4)
GGA: 374056(GPX4)
MGP: 100379155(GPX4)
CJO: 107325473(GPX4)
APLA: 101796330(GPX4)
ACYG: 106048194(GPX4)
TGU: 100190423(GPX4)
GFR: 102045367(GPX4)
FAB: 101817765(GPX4)
PHI: 102113402(GPX4)
PMAJ: 107215549(GPX4)
CCAE: 111940246(GPX4)
CCW: 104697013(GPX4)
FPG: 101916317(GPX4)
FCH: 102055857(GPX4)
CLV: 102092188(GPX4)
EGZ: 104127393(GPX4)
AAM: 106493531(GPX4)
ASN: 102386897(GPX4)
AMJ: 102570581(GPX4)
PSS: 102460999(GPX4)
CMY: 102948400(GPX4)
CPIC: 101944764(GPX4)
ACS: 100563257(gpx4)
PVT: 110079257(GPX4)
PBI: 103065827(GPX4)
GJA: 107107351(GPX4)
XLA: 100036920(gpx4.L) 734888(gpx4.S)
XTR: 100496541(gpx4)
NPR: 108789489(GPX4)
DRE: 352928(gpx4a) 352929(gpx4b)
SANH: 107660382
SGH: 107552704
IPU: 100528418(gpx4)
AMEX: 103026361(gpx4)
TRU: 101066389 101070699(gpx4)
LCO: 104929635 104930512(gpx4)
NCC: 104958153(gpx4)
MZE: 101475014 101481366(gpx4)
XMA: 102218769 102219707(gpx4)
PRET: 103463715(gpx4) 103479268
NFU: 107384121 107393348(gpx4)
KMR: 108230562(gpx4) 108239424
CSEM: 103376758(gpx4) 103395914
BPEC: 110157283 110174007(gpx4)
MALB: 109966994(gpx4) 109969232
SASA: 100194734(gpx4b) 106573579
SFM: 108919780(gpx4) 108921631
CMK: 103189927(gpx4)
CIN: 100175675(gpx_e)
SPU: 100891322
APLC: 110989974
SKO: 102807044
AME: 726269
BIM: 100743362
BTER: 100648859
SOC: 105193617
ACEP: 105625818
PBAR: 105425460
HST: 105183432
DQU: 106745051
CFO: 105248391
LHU: 105668639
PGC: 109853223
PCF: 106790095
NVI: 100114603
MDL: 106693859
DPA: 109546481
PMAC: 106708689
HAW: 110372557
TUT: 107368679
CRG: 105330305
MYI: 110445160
EGL: EGR_06748
ADF: 107353881
HMG: 100212361 100215761(GPx)
SPAR: SPRG_01802
 » show all
Taxonomy
Reference
1  [PMID:3978121]
  Authors
Ursini F, Maiorino M, Gregolin C.
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase.
  Journal
Biochim Biophys Acta 839:62-70 (1985)
DOI:10.1016/0304-4165(85)90182-5
Reference
2  [PMID:8617728]
  Authors
Schnurr K, Belkner J, Ursini F, Schewe T, Kuhn H
  Title
The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products.
  Journal
J Biol Chem 271:4653-8 (1996)
DOI:10.1074/jbc.271.9.4653
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.12
IUBMB Enzyme Nomenclature: 1.11.1.12
ExPASy - ENZYME nomenclature database: 1.11.1.12
BRENDA, the Enzyme Database: 1.11.1.12
CAS: 97089-70-8

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