KEGG   ENZYME: 1.11.1.13Help
Entry
EC 1.11.1.13                Enzyme                                 

Name
manganese peroxidase;
peroxidase-M2;
Mn-dependent (NADH-oxidizing) peroxidase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
BRITE hierarchy
Sysname
Mn(II):hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O [RN:R00011]
Reaction(KEGG)
Substrate
Mn(II) [CPD:C19610];
H+ [CPD:C00080];
H2O2 [CPD:C00027]
Product
Mn(III) [CPD:C19611];
H2O [CPD:C00001]
Comment
A hemoprotein. The enzyme from white rot basidiomycetes is involved in the oxidative degradation of lignin. The enzyme oxidizes a bound Mn2+ ion to Mn3+ in the presence of hydrogen peroxide. The product, Mn3+, is released from the active site in the presence of a chelator (mostly oxalate and malate) that stabilizes it against disproportionation to Mn2+ and insoluble Mn4+ [4]. The complexed Mn3+ ion can diffuse into the lignified cell wall, where it oxidizes phenolic components of lignin and other organic substrates [1]. It is inactive with veratryl alcohol or nonphenolic substrates.
History
EC 1.11.1.13 created 1992
Orthology
K20205  manganese peroxidase
Genes
PXB: 103942159
MTM: MYCTH_2111272
TMN: UCRPA7_7742
SSCK: SPSK_07949
NHE: NECHADRAFT_4582
MAW: MAC_06049
MAJ: MAA_06180
PLJ: VFPFJ_06374
VAL: VDBG_01180
VDA: VDAG_06204
PTE: PTT_13874
ABP: AGABI1DRAFT71350(AGABI1DRAFT_71350) AGABI1DRAFT80178(AGABI1DRAFT_80178)
ABV: AGABI2DRAFT188334(AGABI2DRAFT_188334) AGABI2DRAFT221245(MnP)
 » show all
Taxonomy
Reference
1  [PMID:3800395]
  Authors
Glenn JK, Akileswaran L, Gold MH.
  Title
Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium.
  Journal
Arch Biochem Biophys 251:688-96 (1986)
DOI:10.1016/0003-9861(86)90378-4
Reference
2  [PMID:3080953]
  Authors
Paszczynski A, Huynh VB, Crawford R.
  Title
Comparison of ligninase-I and peroxidase-M2 from the white-rot fungus Phanerochaete chrysosporium.
  Journal
Arch Biochem Biophys 244:750-65 (1986)
DOI:10.1016/0003-9861(86)90644-2
Reference
3  [PMID:3167051]
  Authors
Wariishi H, Akileswaran L, Gold MH.
  Title
Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle.
  Journal
Biochemistry 27:5365-70 (1988)
Reference
4  [PMID:8433984]
  Authors
Kuan IC, Tien M
  Title
Stimulation of Mn peroxidase activity: a possible role for oxalate in lignin biodegradation.
  Journal
Proc Natl Acad Sci U S A 90:1242-6 (1993)
DOI:10.1073/pnas.90.4.1242
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.13
IUBMB Enzyme Nomenclature: 1.11.1.13
ExPASy - ENZYME nomenclature database: 1.11.1.13
UM-BBD (Biocatalysis/Biodegradation Database): 1.11.1.13
BRENDA, the Enzyme Database: 1.11.1.13
CAS: 114995-15-2

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