KEGG   ENZYME: 1.11.1.8
Entry
EC 1.11.1.8                 Enzyme                                 
Name
iodide peroxidase;
thyroid peroxidase;
iodoperoxidase (heme type);
iodide peroxidase-tyrosine iodinase;
thyroperoxidase;
tyrosine iodinase;
TPO;
iodinase
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
iodide:hydrogen-peroxide oxidoreductase
Reaction(IUBMB)
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O [RN:R02810];
(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;
(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;
(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08523];
(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O [RN:R08522]
Reaction(KEGG)
R02810 R08522 R08523;
(other) R03208 R03539 R03953 R03973 R08520 R08521
Substrate
iodide [CPD:C00708];
H2O2 [CPD:C00027];
H+ [CPD:C00080];
[thyroglobulin]-L-tyrosine [CPD:C16733];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731]
Product
diiodine [CPD:C01382];
H2O [CPD:C00001];
[thyroglobulin]-3-iodo-L-tyrosine [CPD:C16732];
[thyroglobulin]-3,5-diiodo-L-tyrosine [CPD:C16731];
[thyroglobulin]-L-thyroxine [CPD:C16729];
[thyroglobulin]-aminoacrylate [CPD:C16734];
[thyroglobulin]-3,5,3'-triiodo-L-thyronine [CPD:C16730]
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
EC 1.11.1.8 created 1961, modified 2012
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00431  thyroid peroxidase
Genes
HSA: 7173(TPO)
PTR: 112208205(TPO)
PPS: 100996140(TPO)
GGO: 101154382(TPO)
PON: 100456793(TPO)
NLE: 100600125(TPO) 115834294
HMH: 116480453(TPO)
MCC: 721610(TPO)
MCF: 102125126(TPO)
MTHB: 126933457
MNI: 105497560(TPO)
CSAB: 103220948(TPO)
CATY: 105587598(TPO)
PANU: 101002980(TPO)
TGE: 112604644(TPO)
MLEU: 105546350(TPO)
RRO: 104680243(TPO)
RBB: 108520786(TPO)
TFN: 117062801(TPO)
PTEH: 111526756(TPO)
CANG: 105525386(TPO)
CJC: 100386952(TPO)
SBQ: 101037216(TPO)
CIMI: 108292902(TPO)
CSYR: 103263957(TPO)
MMUR: 105870505(TPO)
LCAT: 123636559(TPO)
PCOQ: 105824646(TPO)
OGA: 100950962(TPO)
MMU: 22018(Tpo)
MCAL: 110307221(Tpo)
MPAH: 110324682(Tpo)
RNO: 54314(Tpo)
MCOC: 116080994(Tpo)
ANU: 117717370(Tpo)
MUN: 110552563 110561242
CGE: 100774668(Tpo)
MAUA: 101838356(Tpo)
PROB: 127234369(Tpo)
PLEU: 114683239(Tpo)
MORG: 121432305(Tpo)
MFOT: 126491107
AAMP: 119807272(Tpo)
NGI: 103747657(Tpo)
HGL: 101704548(Tpo)
CPOC: 100723704(Tpo)
CCAN: 109698840(Tpo)
DORD: 105995174(Tpo)
DSP: 122100091(Tpo)
PLOP: 125356021(Tpo)
NCAR: 124962925
OCU: 100358662 127486836
OPI: 101529357(TPO)
TUP: 102498362(TPO)
GVR: 103595081(TPO)
CFA: 403521(TPO)
CLUD: 112664926(TPO)
VVP: 112927779(TPO)
VLG: 121491902(TPO)
NPO: 129511138(TPO)
AML: 100482359(TPO)
UMR: 103659385(TPO)
UAH: 113269244(TPO)
UAR: 123786594(TPO)
ELK: 111154148
LLV: 125108840
MPUF: 101677724(TPO)
NVS: 122915502(TPO)
ORO: 101386003(TPO)
EJU: 114206012(TPO)
ZCA: 113937469(TPO)
MLX: 118007270 118007322
NSU: 110587338(TPO)
LWW: 102736066(TPO)
FCA: 101098706(TPO)
PYU: 121044026(TPO)
PCOO: 112864369(TPO)
PBG: 122467124(TPO)
LRUF: 124525761
PTG: 102968585(TPO)
PPAD: 109258749(TPO)
PUC: 125937367
AJU: 106970832
HHV: 120247915(TPO)
BTA: 525013(TPO)
BOM: 102270919(TPO)
BBUB: 102407971(TPO)
BBIS: 104994785(TPO)
CHX: 102182976(TPO)
OAS: 105606468(TPO)
BTAX: 128052765(TPO)
ODA: 120864488(TPO)
CCAD: 122432081(TPO)
MBEZ: 129557445(TPO)
SSC: 445522(TPO)
CFR: 102509347(TPO)
CBAI: 105075311(TPO)
CDK: 105105788(TPO)
VPC: 102531846(TPO)
BACU: 103019738(TPO)
LVE: 103068590(TPO)
OOR: 101277595(TPO)
DLE: 111167991(TPO)
PCAD: 102992243(TPO)
PSIU: 116764397(TPO)
NASI: 112407583(TPO)
ECB: 100072955(TPO)
EPZ: 103558875(TPO)
EAI: 106831426(TPO)
MYB: 102261673(TPO)
MYD: 102752073(TPO)
MMYO: 118669324(TPO)
MNA: 107526670(TPO)
PKL: 118714838(TPO)
HAI: 109384713(TPO)
DRO: 112298003(TPO)
SHON: 118988799(TPO)
AJM: 119053969(TPO)
PDIC: 114498752(TPO)
PHAS: 123822481(TPO)
MMF: 118630987(TPO)
RFQ: 117032670(TPO)
PALE: 102894645(TPO)
PGIG: 120596537(TPO)
PVP: 105306937(TPO)
RAY: 107516248(TPO)
MJV: 108410043(TPO)
TOD: 119258688(TPO)
SARA: 101544834(TPO)
LAV: 100654315(TPO)
TMU: 101356790
ETF: 101650056(TPO)
DNM: 101411611(TPO)
MDO: 100032350(TPO)
GAS: 123233464(TPO)
SHR: 100914346(TPO)
AFZ: 127546516
PCW: 110193820(TPO)
OAA: 100080616(TPO)
GGA: 776120(TPO)
PCOC: 116240489(TPO)
MGP: 100547103(TPO)
CJO: 107312163(TPO)
TPAI: 128087649(TPO)
NMEL: 110396710(TPO)
APLA: 101799650(TPO)
ACYG: 106030804(TPO)
AFUL: 116487946(TPO)
TGU: 100218312(TPO)
LSR: 110482186(TPO)
SCAN: 103822861(TPO)
PMOA: 120505263(TPO)
OTC: 121344293(TPO)
PRUF: 121359149(TPO)
GFR: 102035753(TPO)
FAB: 101810932(TPO)
PHI: 102101957(TPO)
PMAJ: 107202328(TPO)
CCAE: 111926044(TPO)
CCW: 104685517(TPO)
CBRC: 103622838(TPO)
ETL: 114069616(TPO)
ZAB: 102067657(TPO)
ACHL: 103798919(TPO)
SVG: 106849075(TPO)
FPG: 101922364(TPO)
FCH: 102045733(TPO)
CLV: 102095211(TPO)
EGZ: 104122160(TPO)
NNI: 104013841(TPO)
PLET: 104625294
PCRI: 104032438
PCAO: 104047200
ACUN: 113477604(TPO)
TALA: 104359736(TPO)
PADL: 103921358(TPO)
AFOR: 103895897(TPO)
ACHC: 115351124(TPO)
HALD: 104315049(TPO)
HLE: 104831289(TPO)
AGEN: 126046400
GCL: 127014894
CCRI: 104164426(TPO)
EHS: 104504514(TPO)
MUI: 104533545(TPO)
FGA: 104079472(TPO)
GSTE: 104252217(TPO)
LDI: 104351831(TPO)
MNB: 103777585(TPO)
OHA: 104329380(TPO)
SHAB: 115609450(TPO)
DPUB: 104305690(TPO)
PGUU: 104469372(TPO)
ACAR: 104529229(TPO)
CPEA: 104390153(TPO)
AVIT: 104270482(TPO)
CVF: 104289037(TPO)
CUCA: 104064875(TPO)
TEO: 104380949(TPO)
BRHI: 104489655(TPO)
AAM: 106492987(TPO)
AROW: 112973093(TPO)
NPD: 112945458(TPO)
TGT: 104580334(TPO)
DNE: 112992818(TPO)
SCAM: 104143498(TPO)
ASN: 102375780(TPO)
AMJ: 106736998(TPO)
CPOO: 109312104(TPO)
GGN: 109300041(TPO)
PSS: 102447524(TPO)
CMY: 102940210(TPO)
DCC: 119853278(TPO)
CPIC: 101932866(TPO)
TST: 117874041(TPO)
CABI: 116817604(TPO)
MRV: 120401415(TPO)
ACS: 100562991(tpo)
PVT: 110073409(TPO)
SUND: 121925349(TPO)
PBI: 103055216(TPO)
PMUR: 107288276(TPO)
CTIG: 120310082(TPO)
TSR: 106551315(TPO)
PGUT: 117674498(TPO)
PTEX: 113455290(TPO)
NSS: 113410540(TPO)
VKO: 123017669(TPO)
PMUA: 114593754(TPO) 114600521
ZVI: 118078350 118082781(TPO)
HCG: 128339342 128340645(TPO)
GJA: 107108843 107120374(TPO)
STOW: 125426778 125439527(TPO)
XLA: 100049788(tpo.S)
XTR: 100036738(tpo)
NPR: 108789262(TPO)
RTEM: 120936386(TPO)
BBUF: 120999023(TPO)
BGAR: 122935226(TPO)
DRE: 100331172(epx) 569363(tpo)
SRX: 107707791(tpo) 107732259
SANH: 107676453 107678715(tpo) 107701038
SGH: 107594129
CCAR: 109084952 109099142
CAUA: 113042938 113085118(tpo)
CGIB: 128013963 128031820
PTET: 122330629(epx) 122334382(tpo)
LROH: 127156758(epx) 127179243(tpo)
PPRM: 120471728(epx) 120473217 120473261
MAMB: 125247940(epx) 125269309(tpo)
CIDE: 127498092 127507673
MASI: 127435674 127455176
IPU: 108269580 108274988(epx)
PHYP: 113529680 113538844(tpo)
SMEO: 124389670(tpo) 124392946(epx)
TFD: 113653966(epx) 113659460(tpo)
AMEX: 103026466 103032699(tpo)
CMAO: 118811861(epx) 118823206(tpo)
EEE: 113572650(tpo) 113583564
CHAR: 105892418(epx) 105909411(tpo)
TRU: 101062981 101079869 115247027
TNG: GSTEN00010284G001 GSTEN00012455G001
LCO: 104928854 104934649(tpo)
NCC: 104944637
CGOB: 115009405 115027547(tpo)
ELY: 117261785(epx) 117267275
EFO: 125886852(epx) 125901384(tpo)
PLEP: 121950093(epx) 121953636(tpo)
SLUC: 116038497(epx) 116042521(tpo)
ECRA: 117935626(tpo) 117949679(epx)
ESP: 116669921(tpo) 116694341
PFLV: 114547036(tpo) 114560272
GAT: 120808678(epx) 120832611(tpo)
PPUG: 119195992(epx) 119227498(tpo)
MSAM: 119893789(epx) 119910842(tpo)
SCHU: 122862127(tpo) 122875391(epx)
CUD: 121514495(epx) 121526598
ALAT: 119005006(tpo) 119024167(epx)
MZE: 101470734(tpo) 101472649
ONL: 100692514 100700906(tpo)
OAU: 116326276(epx) 120434955(tpo)
OLA: 101167362 105356959(tpo)
OML: 112143527(tpo) 112152280(epx)
XMA: 102230399 102232241
XCO: 114134369 114151183
XHE: 116709035 116709593 116732146
PRET: 103460527 103466494
PFOR: 103141318 103154181(tpo)
PLAI: 106953134(tpo) 106964663
PMEI: 106923933(tpo) 106933097
GAF: 122835368(epx) 122845674(tpo)
CVG: 107100628
CTUL: 119787434(epx) 119797839(tpo)
GMU: 124858077(epx) 124884924(tpo)
NFU: 107388669 107392598(tpo)
KMR: 108230067(epx) 108241739(tpo)
ALIM: 106521174 106521219(tpo)
NWH: 119416466(epx) 119427722(tpo)
AOCE: 111562581(tpo) 111584102
MCEP: 125014719(epx) 125023792(tpo)
CSEM: 103379991(tpo) 103380299
POV: 109624077 109627948(tpo)
SSEN: 122776537(epx) 122783162(tpo)
HHIP: 117756338 117762621(epx)
HSP: 118109462(epx) 118116664(tpo)
LCF: 108886978(epx) 108897943
SDU: 111226032(tpo) 111229744
SLAL: 111666321 111666895 111670224(tpo)
XGL: 120792877(epx) 120795322(tpo)
HCQ: 109507502 109530238
SSCV: 125970095 125981320
BPEC: 110155374(tpo) 110169467
MALB: 109965011(tpo) 109972931
BSPL: 114848308(tpo) 114857330(epx)
SASA: 106584777 106611389(tpo)
STRU: 115161765 115192923
OTW: 112237628(epx) 112256946(tpo)
OMY: 110504252(tpo) 110522697(epx)
OGO: 124037374(epx) 124046982(tpo)
ONE: 115121024
SALP: 112069494(tpo) 112070266
SNH: 120022964 120022991 120051654(epx)
CCLU: 121540756(epx) 121544226(tpo)
ELS: 105028745(tpo) 105029701
SFM: 108942507(tpo)
PKI: 111848005 111857914(tpo)
AANG: 118215539(epx) 118234749(tpo)
LOC: 102695049(tpo)
PSPA: 121294970(epx) 121317659(tpo)
ARUT: 117411246(tpo) 117432329(epx)
PSEX: 120526592(tpo)
LCM: 102362813(TPO)
CMK: 103175078 103185975(tpo)
RTP: 109918711 109928222
CPLA: 122548625(tpo) 122557877
CIN: 100183311 100183818 445593
SCLV: 120346294
PMEO: 129593455
PFLA: Pflav_004530
 » show all
Reference
1  [PMID:13718859]
  Authors
CUNNINGHAM BA, KIRKWOOD S.
  Title
Enzyme systems concerned with the synthesis of monoiodotyrosine. III. Ion requirements of the soluble system.
  Journal
J Biol Chem 236:485-9 (1961)
Reference
2  [PMID:13964156]
  Authors
HOSOYA T, KONDO Y, UI N.
  Title
Peroxidase activity in thyroid gland and partial purification of the enzyme.
  Journal
J Biochem 52:180-9 (1962)
DOI:10.1093/oxfordjournals.jbchem.a127594
Reference
3  [PMID:12325367]
  Authors
Coval ML, Taurog A.
  Title
Purification and iodinating activity of hog thyroid peroxidase.
  Journal
J Biol Chem 242:5510-23 (1967)
Reference
4  [PMID:7021557]
  Authors
Gavaret JM, Cahnmann HJ, Nunez J
  Title
Thyroid hormone synthesis in thyroglobulin. The mechanism of the coupling reaction.
  Journal
J Biol Chem 256:9167-73 (1981)
Reference
5  [PMID:7142155]
  Authors
Ohtaki S, Nakagawa H, Nakamura M, Yamazaki I
  Title
One- and two-electron oxidations of tyrosine, monoiodotyrosine, and diiodotyrosine catalyzed by hog thyroid peroxidase.
  Journal
J Biol Chem 257:13398-403 (1982)
Reference
6  [PMID:6706930]
  Authors
Magnusson RP, Taurog A, Dorris ML
  Title
Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase.
  Journal
J Biol Chem 259:197-205 (1984)
Reference
7  [PMID:2996435]
  Authors
Virion A, Courtin F, Deme D, Michot JL, Kaniewski J, Pommier J
  Title
Spectral characteristics and catalytic properties of thyroid peroxidase-H2O2 compounds in the iodination and coupling reactions.
  Journal
Arch Biochem Biophys 242:41-7 (1985)
DOI:10.1016/0003-9861(85)90477-1
Reference
8  [PMID:1497352]
  Authors
Rawitch AB, Pollock G, Yang SX, Taurog A
  Title
Thyroid peroxidase glycosylation: the location and nature of the N-linked oligosaccharide units in porcine thyroid peroxidase.
  Journal
Arch Biochem Biophys 297:321-7 (1992)
DOI:10.1016/0003-9861(92)90679-Q
  Sequence
[ssc:445522]
Reference
9  [PMID:8448141]
  Authors
Sun W, Dunford HB
  Title
Kinetics and mechanism of the peroxidase-catalyzed iodination of tyrosine.
  Journal
Biochemistry 32:1324-31 (1993)
DOI:10.1021/bi00056a018
Reference
10 [PMID:8651700]
  Authors
Taurog A, Dorris ML, Doerge DR
  Title
Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase.
  Journal
Arch Biochem Biophys 330:24-32 (1996)
DOI:10.1006/abbi.1996.0222
Reference
11 [PMID:16098474]
  Authors
Ruf J, Carayon P
  Title
Structural and functional aspects of thyroid peroxidase.
  Journal
Arch Biochem Biophys 445:269-77 (2006)
DOI:10.1016/j.abb.2005.06.023
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.8
IUBMB Enzyme Nomenclature: 1.11.1.8
ExPASy - ENZYME nomenclature database: 1.11.1.8
BRENDA, the Enzyme Database: 1.11.1.8
CAS: 9031-28-1

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (18)   
   KEGG COMPOUND (18)   
Chemical reaction (14)   
   KEGG REACTION (9)   
   KEGG RCLASS (5)   
Gene (824)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (444)   
   KEGG MGENES (60)   
   RefGene (319)   
Protein sequence (437)   
   UniProt (410)   
   SWISS-PROT (5)   
   RefSeq(pep) (13)   
   PDBSTR (2)   
   PMD (7)   
DNA sequence (40)   
   RefSeq(nuc) (16)   
   GenBank (15)   
   EMBL (9)   
3D Structure (2)   
   PDB (2)   
Protein domain (12)   
   InterPro (10)   
   PROSITE(DOC) (2)   
All databases (1352)   

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