KEGG ENZYME: 1.11.2.2

ENZYME: 1.11.2.2

Entry

EC 1.11.2.2                 Enzyme

Name

myeloperoxidase;
MPO;
verdoperoxidase

Class

Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases

Sysname

chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming)

Reaction(IUBMB)

Cl- + H2O2 + H+ = HClO + H2O [RN:R09564]

Reaction(KEGG)

R09564;
(other) R11906

Substrate

Cl- [CPD:C00698];
H2O2 [CPD:C00027];
H+ [CPD:C00080]

Product

HClO [CPD:C19697];
H2O [CPD:C00001]

Comment

Contains calcium and covalently bound heme (proximal ligand histidine). It is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. It differs from EC 1.11.1.10 chloride peroxidase in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). Hypochlorite in turn forms a number of antimicrobial products (Cl2, chloramines, hydroxyl radical, singlet oxygen). MPO also oxidizes bromide, iodide and thiocyanate. In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.

History

EC 1.11.2.2 created 2011

Pathway

ec00983

Drug metabolism - other enzymes

Orthology

K10789

myeloperoxidase

Genes

HSA:

4353(MPO)

PTR:	748680(MPO)

PPS:	100992079(MPO)

GGO:	101135280(MPO)

PON:	100461693(MPO)

PPYG:

129017404(MPO)

NLE:	100606582(MPO)

HMH:	116474400(MPO)

SSYN:

129469851(MPO)

MCC:	714246(MPO)

MCF:	102130410(MPO)

MTHB:

126939378

MNI:	105476815(MPO)

CSAB:

103242854(MPO)

CATY:

105583311(MPO)

PANU:

101011165(MPO)

TGE:	112609921(MPO)

MLEU:

105539090(MPO)

RRO:	104669826(MPO)

RBB:	108521655(MPO)

TFN:	117067295(MPO)

PTEH:

111537628(MPO)

CANG:

105520104(MPO)

CJC:	100408045(MPO)

SBQ:	101046117(MPO)

CIMI:

108312045(MPO)

ANAN:

105712463(MPO)

CSYR:

103266720(MPO)

MMUR:

105870807(MPO)

LCAT:

123620433(MPO)

PCOQ:

105813680(MPO)

OGA:	100962386(MPO)

MMU:	17523(Mpo)

MCAL:

110305648(Mpo)

MPAH:

110331385(Mpo)

RNO:	303413(Mpo)

MCOC:

116077242(Mpo)

ANU:	117711028(Mpo)

ASYL:

127694027(Mpo)

MUN:	110566146(Mpo)

CGE:	100752227(Mpo) 100757792

MAUA:

101830171(Mpo)

PROB:

127226708(Mpo)

PLEU:

114699237 114699257

MORG:

121456890(Mpo)

MFOT:

126510373

AAMP:

119813072(Mpo)

NGI:	103741805(Mpo)

HGL:	101707361(Mpo)

CPOC:

100725291(Mpo)

CCAN:

109674413 109702951

DORD:

105983334(Mpo)

DSP:	122119242(Mpo)

DMER:

138830349(Mpo)

PLOP:

125366055 125366110(Mpo)

NCAR:

124980398

MMMA:

107150408(Mpo)

ITI:	101964731(Mpo)

OCU:

100340692

OPI:	101519625(MPO)

TUP:	102501858(MPO)

GVR:	103589313(MPO)

CFA:	609986(MPO)

CLUD:

112655186(MPO)

VVP:	112918144(MPO)

VLG:	121473582(MPO)

NPO:	129513417(MPO)

AML:	100472895(MPO)

UMR:	103667463(MPO)

UAH:	113268870(MPO)

UAR:	123777005(MPO)

ELK:

111151617

LLV:

125088054

MPUF:

101693526(MPO)

MNP:	132003622(MPO)

MLK:	131816606(MPO)

NVS:	122907701(MPO)

ORO:	101380182(MPO)

EJU:	114213918(MPO)

ZCA:	113907839(MPO)

MLX:	118025032(MPO)

NSU:	110592908(MPO)

LWW:	102738452(MPO)

FCA:	100142673(MPO)

PYU:

121044726

PCOO:

112855538

PBG:	122485326(MPO)

PVIV:

125151551(MPO)

LRUF:

124512901

LGF:	123603393(MPO)

AJU:

106989943

PTG:	102973033(MPO)

PPAD:

109247205(MPO)

PUC:

125927445

PLEZ:

122206099(MPO)

HHV:	120241939(MPO)

BTA:	511206(MPO)

BOM:	102286491(MPO)

BIU:	109573426(MPO)

BBUB:

102404921(MPO)

BBIS:

105004105(MPO)

CHX:	102185772(MPO)

OAS:	101123053(MPO)

BTAX:

128065174(MPO)

CSUM:

138083717(MPO)

ODA:	120866469(MPO)

CCAD:

122449725(MPO)

MREE:

136149419(MPO) 136149423

OVR:	110142788(MPO)

MBEZ:

129539145(MPO)

SSC:	100517120(MPO)

CFR:	102510136(MPO)

CBAI:

105065870(MPO)

CDK:	105097806(MPO)

VPC:	102544839(MPO)

BACU:

103004965(MPO)

BMUS:

118886850(MPO)

LVE:	103083642(MPO)

OOR:	101290133(MPO)

LALB:

132510944(MPO)

GMF:	115866292(MPO)

DDP:	132415104(MPO)

DLE:	111163673(MPO)

PCAD:

102982078(MPO)

PSIU:

116745756(MPO)

PPHC:

136138812(MPO)

NASI:

112408073(MPO)

ECB:	100070920(MPO)

EPZ:	103546343(MPO)

EAI:	106822013(MPO)

MYB:	102240978(MPO)

MYD:	102756726(MPO)

MMYO:

118671763(MPO)

MLF:	102433380(MPO)

MDT:	132218410(MPO)

MYUM:

138993658(MPO)

PKL:	118728102(MPO)

EFUS:

103291649(MPO)

MNA:	107535307(MPO)

DRO:	112316355(MPO)

SHON:

119003703(MPO)

AJM:	119062632(MPO)

PDIC:

114503163(MPO)

PHAS:

123817428(MPO)

MMF:	118634389(MPO)

PPAM:

129080247(MPO)

HAI:	109379730(MPO)

RFQ:	117013909(MPO)

PALE:

102883356(MPO)

PGIG:

120621150(MPO)

PVP:	105302124(MPO)

RAY:	107499177(MPO)

MJV:	108397175(MPO)

TOD:	119231003(MPO)

SARA:

101554218(MPO)

SFUM:

130035835(MPO)

SETR:

126006222

LAV:	100662013(MPO)

TMU:

101340378

ETF:	101661945(MPO)

DNM:	101415126(MPO)

MDO:	100012330(MPO) 100022606

GAS:	123246127(MPO) 123246781

SHR:

100918289

AFZ:

127559988

PCW:

110212135

TVP:	118847993 118857479

PBRV:

138145747

MLAO:

141513623

OAA:	100078069(MPO)

TACU:

119939428(MPO)

GGA:	417466(LPO) 417467(MPO)

PCOC:

116228224(LPO)

MGP:	100547955(LPO)

TPAI:

128083727

LMUT:

125703182 125703183

NMEL:

110407540(EPX) 110407753

APLA:

101801315 101805061

ACYG:

106041022 106041024(MPO)

CATA:

118254071 118254112

AFUL:

116497396 116497447

TGU:	116809116 116809130

LSR:	110475906 110475908

SCAN:

103820227

PMOA:

120513448 120513449

OTC:	121346857(EPX) 121346871

PRUF:

121362958 121362959(EPX)

ATRC:

139600061 139600064

GFR:	102033956(EPX) 102037835(MPO)

FAB:	101813304(EPX) 101820562(MPO)

OMA:	130260827 130260829

CCAE:

111937619

CCW:	104695782 104695807

CBRC:

103618347 103618349

ACOE:

138120503 138120770

ETL:	114063780 114063781

ZAB:	102063561 102067212

ZLE:	135455714 135455722

ACHL:

103802301 103802303 103808840

SVG:	106856240 106856242

MMEA:

130574635 130574636

HRT:	120761526 120761527(MPO)

SATI:

136369957 136370323

CCIC:

134052454 134052521

FPG:	101914513(EPX) 101914689(MPO)

FCH:	102052043 102052208

CCRI:

104165474 104167995

NNT:

104407111

SHAB:

115603115

ACUN:

113487144 113487180(MPO)

TALA:

104366892 104366894

ACHC:

115347511 115347673

HALD:

104314380 104314381

HLE:	104843177 104843179

AGEN:

126039372 126039769

HHAR:

128149314 128149568

GCL:	127024572 127024573

CSTI:

104553514

LDI:	104352898 104352899

MNB:	103768197 103768198

DPUB:

104300255(MPO)

PPUS:

135187496(MPO)

AVIT:

104268383

BRHI:

104492875

EGZ:	104131757 104131758(MPO)

NNI:	104012465(LPO)

PCRI:

104024842

PCAO:

104041373 104049832

PADL:

103916612 103916613

AFOR:

103896569 103896570

FGA:	104083379 104083380

GSTE:

104253887 104256813

CBOY:

140661026 140661027

CLV:	102084173 102084361

CNIC:

135995626 135995635

MUI:	104536751 104539284

PGUU:

104466180 104466182(LPO)

PLET:

104628114 104628115

EHS:	104506248 104506249

CMAC:

104478087 104482911

CUCA:

104057358 104057361(MPO)

TEO:

104382061

BREG:

104631223 104635066

OHA:	104334726(EPX)

ACAR:

104531742 104531743

CPEA:

104391004 104391006(MPO)

CVF:	104289864 104289865

RTD:	128912540(EPX)

CRID:

134518398

AAM:	106496096 106496104(MPO)

AROW:

112964994 112965020(MPO)

NPD:	112956708(MPO) 112956744

TGT:

104572398

DNE:	112987317 112987346

SCAM:

104146231(MPO) 104146262

ASN:	102372031 102379880

AMJ:	102559230(LPO)

CPOO:

109317469 109317472

GGN:	109288980 109289040

PSS:	102454048 102463089

CMY:	102933916 102934149 102941880

CCAY:

125623878(MPO) 125624086

DCC:	119844603 119844854

CPIC:

101935994 101946833 101947097

TST:	117867690(MPO) 117867693 117867698

CABI:

116818731(MPO) 116818741 116818742

MRV:	120387502 120387503 120387580

ACS:	100567371 107983822

ASAO:

132770131

PVT:	110084498 110084515

SUND:

121916987

PBI:	103062626 103062866(LPO)

PMUR:

107288571(MPO)

CTIG:

120309089 120309240(MPO)

TSR:	106549249(MPO) 106553876(LPO)

PGUT:

117667550

PCAE:

139318720

APRI:

131188877

PTEX:

113441577

NSS:

113414537

VKO:	123036688 123036689

PMUA:

114585840

PRAF:

128403129

ZVI:

118097261

GJA:

107112485

STOW:

125445776 125446010

EMC:	129344790 129344902

XLA:	373710(mpo.S) 394386(mpo.L) 398084(epx.L)

XTR:	100490938(mpo) 100496213(epx)

NPR:	108785838 108785844 108797850

RTEM:

120927532 120927666 120927668 120927671

ACAT:

141128897 141129023 141129025

BBUF:

120993645 120993647 120993648 120994701 120994817

BGAR:

122931700 122931701 122931839 122931840 122932447 122932595 122940269

DTC:	141078618 141080382 141080384 141080538

PWL:	138268679 138286513 138286514(EPX)

MUO:

115456483

GSH:	117349196(MPO)

SRX:

107713297

SANH:

107688477

SGH:

107569391

CCAR:

109052003 109052034 109055972

SASA:

100380666(perm)

OTW:

112231092

OMY:

110509901

SALP:

111964113

SFM:	108930109 108932527

LCM:	102347787 102348047(MPO)

RTP:

109913294

CPLA:

122564095

HAKA:

140731789

AJJ:	139980957 139981471

BCOO:

119072211 119073474 119084658

FOC:	113214016 113217140

TPAL:

117644798

PTRU:

123513466

ESN:	126992742 126999343 126999344

TCF:	131877769 131881259 131881559 131892322 131893385

LPOL:

106472752

PMEO:

129584437

PVUL:

126814675 126815268 126818155

LSAX:

138964780 138965312 138978368

BGT:

106065603

HRF:	124118159 124122769 124136579 124136580 124141281 124141282 124141286 124141289

HRJ:	124253595 124256926 124262128

HCRA:

139452064

CRG:	105319077 105333777 105347615 117683867 136271899

CANU:

128162520 128163610 128181364 128192858

CVN:	111099498 111099865 111099927 111101154 111101742 111102226 111114088 111123883

OED:	125665352 125682350 125682351

PMAX:

117340028 117342135

AIRR:

138307482 138322323

MMER:

123537740 123538598 123539213 123541376 123546341

RPHI:

132724008 132725507 132727046 132729624 132735490 132739235 132741246

DPOL:

127845366 127845367 127847020 127848042 127849115 127849117 127849118 127860390 127863206 127866032 127873828 127878283 127879920

OSN:

115216508

LJP:

135477773

XEN:

124440570

HSY:	130613418 130613480

NGR:	NAEGRDRAFT_70645

» show all

Reference

Authors

Agner K.

Title

Myeloperoxidase.

Journal

Adv Enzymol 3:137-148 (1943)

Reference

2 [PMID:176150]

Authors

Harrison JE, Schultz J

Title

Studies on the chlorinating activity of myeloperoxidase.

Journal

J Biol Chem 251:1371-4 (1976)

Reference

3 [PMID:9922160]

Authors

Furtmuller PG, Burner U, Obinger C

Title

Reaction of myeloperoxidase compound I with chloride, bromide, iodide, and thiocyanate.

Journal

Biochemistry 37:17923-30 (1998)
DOI:10.1021/bi9818772

Reference

4 [PMID:10652281]

Authors

Tuynman A, Spelberg JL, Kooter IM, Schoemaker HE, Wever R

Title

Enantioselective epoxidation and carbon-carbon bond cleavage catalyzed by Coprinus cinereus peroxidase and myeloperoxidase.

Journal

J Biol Chem 275:3025-30 (2000)
DOI:10.1074/jbc.275.5.3025

Reference

5 [PMID:15689384]

Authors

Klebanoff SJ

Title

Myeloperoxidase: friend and foe.

Journal

J Leukoc Biol 77:598-625 (2005)
DOI:10.1189/jlb.1204697

Reference

6 [PMID:10766826]

Authors

Fiedler TJ, Davey CA, Fenna RE

Title

X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.

Journal

J Biol Chem 275:11964-71 (2000)
DOI:10.1074/jbc.275.16.11964

Sequence

[hsa:4353]

Reference

7 [PMID:11593004]

Authors

Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW

Title

Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.

Journal

Proc Natl Acad Sci U S A 98:11961-6 (2001)
DOI:10.1073/pnas.211190298

Other DBs

ExplorEnz - The Enzyme Database:

1.11.2.2

IUBMB Enzyme Nomenclature:

1.11.2.2

ExPASy - ENZYME nomenclature database:

1.11.2.2

BRENDA, the Enzyme Database:

1.11.2.2

All links

Gene (205)   
   MGENES (77)   
   RefGene (128)   
Protein sequence (337)   
   UniProt (207)   
   SWISS-PROT (2)   
   RefSeq(pep) (2)   
   PDBSTR (126)   
DNA sequence (6)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (1)   
3D Structure (25)   
   PDB (25)   
Protein domain (3)   
   InterPro (3)   
All databases (576)   

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