KEGG   ENZYME: 1.12.1.2Help
Entry
EC 1.12.1.2                 Enzyme                                 

Name
hydrogen dehydrogenase;
H2:NAD+ oxidoreductase;
NAD+-linked hydrogenase;
bidirectional hydrogenase;
hydrogenase
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
hydrogen:NAD+ oxidoreductase
Reaction(IUBMB)
H2 + NAD+ = H+ + NADH [RN:R00700]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003]
Product
H+ [CPD:C00080];
NADH [CPD:C00004]
Comment
An iron-sulfur flavoprotein (FMN or FAD). Some forms of this enzyme contain nickel.
History
EC 1.12.1.2 created 1972, modified 2002
Orthology
K00436  NAD-reducing hydrogenase large subunit
K18005  [NiFe] hydrogenase diaphorase moiety large subunit
K18006  [NiFe] hydrogenase diaphorase moiety small subunit
K18007  NAD-reducing hydrogenase small subunit
Genes
GHO: AL542_16860 AL542_16865 AL542_16870 AL542_16875
PIN: Ping_1215 Ping_1216 Ping_1217
MCA: MCA0114 MCA2724 MCA2725 MCA2726
MMT: Metme_0247 Metme_0248 Metme_0249 Metme_0250
MDN: JT25_003635 JT25_003640 JT25_003645 JT25_003650
MDH: AYM39_16540 AYM39_16545 AYM39_16550 AYM39_16555
MKO: MKLM6_3400 MKLM6_3401 MKLM6_3402 MKLM6_3403
MAH: MEALZ_1304(hoxH) MEALZ_1305(hoxY) MEALZ_1306 MEALZ_1307(hoxF)
MPSY: CEK71_01410 CEK71_01420 CEK71_01425 CEK71_01430
CYQ: Q91_0786 Q91_0787 Q91_0788 Q91_0789
CZA: CYCME_1794(hoxX) CYCME_1795(hoxY) CYCME_1796(hoxU) CYCME_1797(hoxF)
REH: PHG088(hoxF) PHG089(hoxU) PHG090(hoxY) PHG091(hoxH)
RME: Rmet_1522(hoxF) Rmet_1523(hoxU) Rmet_1524(hoxY) Rmet_1525(hoxH)
BXB: DR64_7916(hoxH) DR64_7917(hoxY) DR64_7918(hoxU) DR64_7919(hoxF)
CBAA: SRAA_1133(hoxF) SRAA_1134(hoxU) SRAA_1135(hoxY) SRAA_1136(hoxH)
CBAB: SMCB_1158(hoxF) SMCB_1159(hoxU) SMCB_1160(hoxY) SMCB_1161(hoxH)
AZO: azo1412(hoxF) azo1413(hoxU) azo1414(hoxY) azo1415(hoxH)
AZA: AZKH_3040(hoxH) AZKH_3041(hoxY) AZKH_3042(hoxU) AZKH_3043(hoxF)
GSU: GSU2718(hoxL) GSU2719(hoxS)
GSK: KN400_2661(hoxL) KN400_2662(hoxS)
GME: Gmet_1112(hoxS) Gmet_1113(hoxL)
BVR: BVIR_497
HDI: HDIA_0428(hoxH) HDIA_0429(hoxY) HDIA_0430(hoxU) HDIA_0431(hoxF)
MAGX: XM1_4287(hoxH) XM1_4288(hoxY) XM1_4289(hoxU) XM1_4290(hoxF)
SYN: sll1224(hoxY) sll1226(hoxH)
SYZ: MYO_115290(hoxH) MYO_115320(hoxY)
SYY: SYNGTS_1516(hoxH) SYNGTS_1519(hoxY)
SYT: SYNGTI_1516(hoxH) SYNGTI_1519(hoxY)
SYS: SYNPCCN_1515(hoxH) SYNPCCN_1518(hoxY)
SYQ: SYNPCCP_1515(hoxH) SYNPCCP_1518(hoxY)
SYJ: D082_26240(hoxH) D082_26260(hoxY)
SYC: syc1554_d(hoxY) syc1555_d(hoxH)
CYI: CBM981_1702(hoxH) CBM981_1703(mvhG)
PMB: A9601_00341(dhsS)
PMG: P9301_00341(dhsS)
PME: NATL1_00331(dhsS)
AMR: AM1_D0183 AM1_D0187(hoxH)
MAR: MAE_14210(hoxH) MAE_57940(hoxY)
CYT: cce_2315(hoxH) cce_2316(hoxY)
ARP: NIES39_L04020(hoxH) NIES39_L04030(hoxY)
ANA: alr0764(hoxY) alr0766(hoxH)
NAZ: Aazo_4256
NSP: BMF81_04255(hoxH) BMF81_04256(hoxY)
ATM: ANT_09660(hoxH) ANT_09670(hoxY) ANT_12540(hoxY) ANT_12550(hoxH)
CAP: CLDAP_28460(hoxH) CLDAP_28470(hoxY)
PBF: CFX0092_A0141(hoxY) CFX0092_A0142(hoxH)
PBOR: BSF38_02026(hoxH_1) BSF38_03469(hoxY) BSF38_03470
PBAS: SMSP2_00049(hoxF)
VBL: L21SP4_01307(hoxF)
BLQ: L21SP5_00831(hoxF)
MBAS: ALGA_3124
CCH: Cag_0245
IAL: IALB_0256
BANA: BARAN1_0492(hoxH) BARAN1_0493(hoxY)
HTI: HTIA_1873(hoxH)
 » show all
Taxonomy
Reference
1  [PMID:13968752]
  Authors
BONE DH, BERNSTEIN S, VISHNIAC W.
  Title
Purification and some properties of different forms of hydrogen dehydrogenase.
  Journal
Biochim Biophys Acta 67:581-8 (1963)
Reference
2  [PMID:186126]
  Authors
Schneider K, Schlegel HG.
  Title
Purification and properties of soluble hydrogenase from Alcaligenes eutrophus H 16.
  Journal
Biochim Biophys Acta 452:66-80 (1976)
DOI:10.1016/0005-2744(76)90058-9
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.2
IUBMB Enzyme Nomenclature: 1.12.1.2
ExPASy - ENZYME nomenclature database: 1.12.1.2
BRENDA, the Enzyme Database: 1.12.1.2
CAS: 9027-05-8

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